Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5
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Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5. / Eriksen, Hanne-Lise Falgreen ; Kesmodel, Ulrik Schiøler; Wimberley, Theresa; Underbjerg, Mette; Kilburn, Tina Røndrup; Mortensen, Erik Lykke.
In: Journal of Pregnancy, Vol. 2012, 2012, p. 945196.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5
AU - Eriksen, Hanne-Lise Falgreen
AU - Kesmodel, Ulrik Schiøler
AU - Wimberley, Theresa
AU - Underbjerg, Mette
AU - Kilburn, Tina Røndrup
AU - Mortensen, Erik Lykke
PY - 2012
Y1 - 2012
N2 - The aim of the study was to examine the effects of tobacco smoking in pregnancy on children's IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised. Parental education, maternal IQ, maternal alcohol consumption in pregnancy, the sex and age of the child, and tester were considered core confounders, but the full model also controlled for prenatal paternal smoking, maternal age and Bodymass Mass Index, parity, family/home environment, postnatal parental smoking, breast feeding, the child's health status, and indicators for hearing and vision impairments. Unadjusted analyses showed a statistically significant decrement of 4 points on full-scale IQ (FSIQ) associated with smoking 10+ cigarettes per day compared to nonsmoking. After adjustment for potential confounders, no significant effects of prenatal exposure to tobacco smoking were found. Considering the indisputable teratogenic effects of tobacco smoking, these findings should be interpreted with caution. Still, the results may indicate that previous studies that failed to control for important confounders, particularly maternal intelligence, may be subject to substantial residual confounding.
AB - The aim of the study was to examine the effects of tobacco smoking in pregnancy on children's IQ at the age of 5. A prospective follow-up study was conducted on 1,782 women, and their offspring were sampled from the Danish National Birth Cohort. At 5 years of age, the children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised. Parental education, maternal IQ, maternal alcohol consumption in pregnancy, the sex and age of the child, and tester were considered core confounders, but the full model also controlled for prenatal paternal smoking, maternal age and Bodymass Mass Index, parity, family/home environment, postnatal parental smoking, breast feeding, the child's health status, and indicators for hearing and vision impairments. Unadjusted analyses showed a statistically significant decrement of 4 points on full-scale IQ (FSIQ) associated with smoking 10+ cigarettes per day compared to nonsmoking. After adjustment for potential confounders, no significant effects of prenatal exposure to tobacco smoking were found. Considering the indisputable teratogenic effects of tobacco smoking, these findings should be interpreted with caution. Still, the results may indicate that previous studies that failed to control for important confounders, particularly maternal intelligence, may be subject to substantial residual confounding.
U2 - 10.1155/2012/945196
DO - 10.1155/2012/945196
M3 - Journal article
C2 - 23316364
VL - 2012
SP - 945196
JO - Journal of Pregnancy
JF - Journal of Pregnancy
SN - 2090-2727
ER -
ID: 44583434