Efficacy of dietary manipulations for depleting intrahepatic triglyceride content: Implications for the management of non-alcoholic fatty liver disease
Research output: Contribution to journal › Review › Research › peer-review
Standard
Efficacy of dietary manipulations for depleting intrahepatic triglyceride content: Implications for the management of non-alcoholic fatty liver disease. / Sandby, Karoline; Geiker, Nina Rica Wium; Dalamaga, Maria; Grønbæk, Henning; Magkos, Faidon.
In: Current Obesity Reports, Vol. 10, No. 2, 2021, p. 125-133.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Efficacy of dietary manipulations for depleting intrahepatic triglyceride content: Implications for the management of non-alcoholic fatty liver disease
AU - Sandby, Karoline
AU - Geiker, Nina Rica Wium
AU - Dalamaga, Maria
AU - Grønbæk, Henning
AU - Magkos, Faidon
N1 - CURIS 2021 NEXS 072
PY - 2021
Y1 - 2021
N2 - Purpose of review: Understanding the effects of dietary manipulations on intrahepatic triglyceride (IHTG) balance will have important implications for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD).Recent findings: Reducing calorie intake to induce weight loss is the most potent intervention to decrease IHTG. Carbohydrate restriction during the initial stages of weight loss may be particularly beneficial, but at later stages, the amount of weight loss predominates over diet composition. By contrast, during weight stability, restricting calories from fat seems to be optimal for depleting liver fat. The degree of dietary fat saturation and the glycemic index of the carbohydrate have inconsistent effects on IHTG. Recently, the matrix of some foods (e.g., dairy) has been inversely associated with NAFLD. Summary: Dietary macronutrients differ in their effects on liver fat depending on the energy balance and the matrix of the food in which they are consumed. Therefore, investigations into dietary approaches for managing NAFLD should shift their perspective from that of isolated nutrients to that of whole foods and diets and include useful mechanistic insights.
AB - Purpose of review: Understanding the effects of dietary manipulations on intrahepatic triglyceride (IHTG) balance will have important implications for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD).Recent findings: Reducing calorie intake to induce weight loss is the most potent intervention to decrease IHTG. Carbohydrate restriction during the initial stages of weight loss may be particularly beneficial, but at later stages, the amount of weight loss predominates over diet composition. By contrast, during weight stability, restricting calories from fat seems to be optimal for depleting liver fat. The degree of dietary fat saturation and the glycemic index of the carbohydrate have inconsistent effects on IHTG. Recently, the matrix of some foods (e.g., dairy) has been inversely associated with NAFLD. Summary: Dietary macronutrients differ in their effects on liver fat depending on the energy balance and the matrix of the food in which they are consumed. Therefore, investigations into dietary approaches for managing NAFLD should shift their perspective from that of isolated nutrients to that of whole foods and diets and include useful mechanistic insights.
KW - Faculty of Science
KW - Diet composition
KW - Energy balance
KW - Food matrix
KW - Macronutrients
KW - NAFLD
KW - Weight loss
U2 - 10.1007/s13679-021-00430-4
DO - 10.1007/s13679-021-00430-4
M3 - Review
C2 - 33580876
VL - 10
SP - 125
EP - 133
JO - Current Obesity Reports
JF - Current Obesity Reports
SN - 2162-4968
IS - 2
ER -
ID: 256979005