Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris)
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Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood : A European Mother-Child Study (NewGeneris). / Pedersen, Marie; Mendez, Michelle A; Schoket, Bernadette; Godschalk, Roger W; Espinosa, Ana; Landström, Anette; Villanueva, Cristina M; Merlo, Domenico F; Fthenou, Eleni; Gracia-Lavedan, Esther; van Schooten, Frederik-J; Hoek, Gerard; Brunborg, Gunnar; Meltzer, Helle M; Alexander, Jan; Nielsen, Jeanette Kolstrup Søgaard; Sunyer, Jordi; Wright, John; Kovács, Katalin; de Hoogh, Kees; Gutzkow, Kristine B; Hardie, Laura J; Chatzi, Leda; Knudsen, Lisbeth E.; Anna, Lívia; Ketzel, Matthias; Haugen, Margaretha; Botsivali, Maria; Nieuwenhuijsen, Mark J; Cirach, Marta; Toledano, Mireille B; Smith, Rachel B; Fleming, Sarah; Agramunt, Silvia; Kyrtopoulos, Soterios A; Lukács, Viktória; Kleinjans, Jos C; Segerbäck, Dan; Kogevinas, Manolis.
In: Environmental Health Perspectives, Vol. 123, No. 4, 04.2015, p. 374-380.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood
T2 - A European Mother-Child Study (NewGeneris)
AU - Pedersen, Marie
AU - Mendez, Michelle A
AU - Schoket, Bernadette
AU - Godschalk, Roger W
AU - Espinosa, Ana
AU - Landström, Anette
AU - Villanueva, Cristina M
AU - Merlo, Domenico F
AU - Fthenou, Eleni
AU - Gracia-Lavedan, Esther
AU - van Schooten, Frederik-J
AU - Hoek, Gerard
AU - Brunborg, Gunnar
AU - Meltzer, Helle M
AU - Alexander, Jan
AU - Nielsen, Jeanette Kolstrup Søgaard
AU - Sunyer, Jordi
AU - Wright, John
AU - Kovács, Katalin
AU - de Hoogh, Kees
AU - Gutzkow, Kristine B
AU - Hardie, Laura J
AU - Chatzi, Leda
AU - Knudsen, Lisbeth E.
AU - Anna, Lívia
AU - Ketzel, Matthias
AU - Haugen, Margaretha
AU - Botsivali, Maria
AU - Nieuwenhuijsen, Mark J
AU - Cirach, Marta
AU - Toledano, Mireille B
AU - Smith, Rachel B
AU - Fleming, Sarah
AU - Agramunt, Silvia
AU - Kyrtopoulos, Soterios A
AU - Lukács, Viktória
AU - Kleinjans, Jos C
AU - Segerbäck, Dan
AU - Kogevinas, Manolis
PY - 2015/4
Y1 - 2015/4
N2 - BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.
AB - BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.
U2 - 10.1289/ehp.1408613
DO - 10.1289/ehp.1408613
M3 - Journal article
C2 - 25626179
VL - 123
SP - 374
EP - 380
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 4
ER -
ID: 137756071