ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
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- ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
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Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.
| Original language | English |
|---|---|
| Journal | Cell Reports |
| Volume | 29 |
| Issue number | 9 |
| Pages (from-to) | 2756-2769.e6 |
| Number of pages | 21 |
| ISSN | 2211-1247 |
| DOIs | |
| Publication status | Published - 26 Nov 2019 |
- B cell development, ERG, ETS-related gene, immunoglobulin heavy-chain gene, pre-BCR, transcriptional control, V(D)J recombination
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