Exposure to brominated trihalomethanes in water during pregnancy and micronuclei frequency in maternal and cord blood lymphocytes

Research output: Contribution to journalJournal articleResearchpeer-review

Leslie Thomas Stayner, Marie Pedersen, Evridiki Patelarou, Ilse Decordier, Kim Vande Loock, Leda Chatzi, Ana Espinosa, Eleni Fthenou, Mark J Nieuwenhuijsen, Esther Gracia-Lavedan, Euripides G Stephanou, Micheline Kirsch-Volders, Manolis Kogevinas

BACKGROUND: Water disinfection by-products have been associated with an increased cancer risk. Micronuclei (MN) frequency in lymphocytes is a marker of genomic damage and can predict adult cancer risk.

OBJECTIVE: We evaluated maternal exposure to drinking water brominated trihalomethanes (BTHM) in relation to MN frequency in maternal and cord blood lymphocytes.

METHODS: MN frequency was examined in 214 mothers and 223 newborns from the Rhea mother-child cohort in Crete, Greece, in 2007-2008. Residential BTHM water concentrations were estimated during pregnancy using tap water analyses and modeling. Questionnaires on water related habits were used to estimate BTHM exposure from all routes. Associations between BTHM and MN frequency were estimated using negative binomial regression.

RESULTS: BTHM concentrations in residential tap water during pregnancy ranged from 0.06 to 7.1 μg/L. MN frequency in maternal binucleated lymphocytes was found to increase with BTHM concentrations in residential water for exposure during the first [rate ratio (RR) for 1 μg/L=1.05; 95% CI: 1.00, 1.11] and second trimesters (RR for 1 μg/L=1.03; 95% CI: 1.00, 1.06), and through all routes of BTHM exposure during the first trimester (RR for 1 μg/week=3.14; 95% CI: 1.16, 8.50).

CONCLUSIONS: These findings suggest that exposure to BTHM may increase the frequency of MN in maternal binucleated lymphocytes.

Original languageEnglish
JournalEnvironmental Health Perspectives
Volume122
Issue number1
Pages (from-to)100-6
Number of pages7
ISSN0091-6765
DOIs
Publication statusPublished - Jan 2014

ID: 143933656