Exposure to nitrate from drinking water and the risk of childhood cancer in Denmark
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Exposure to nitrate from drinking water and the risk of childhood cancer in Denmark. / Stayner, Leslie T.; Schullehner, Jorg; Semark, Birgitte Dige; Jensen, Anja Søndergaard; Trabjerg, Betina B.; Pedersen, Marie; Olsen, Jorn; Hansen, Birgitte; Ward, Mary H.; Jones, Rena R.; Coffman, Vanessa R.; Pedersen, Carsten B.; Sigsgaard, Torben.
In: Environment International, Vol. 155, 106613, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exposure to nitrate from drinking water and the risk of childhood cancer in Denmark
AU - Stayner, Leslie T.
AU - Schullehner, Jorg
AU - Semark, Birgitte Dige
AU - Jensen, Anja Søndergaard
AU - Trabjerg, Betina B.
AU - Pedersen, Marie
AU - Olsen, Jorn
AU - Hansen, Birgitte
AU - Ward, Mary H.
AU - Jones, Rena R.
AU - Coffman, Vanessa R.
AU - Pedersen, Carsten B.
AU - Sigsgaard, Torben
PY - 2021
Y1 - 2021
N2 - Background: There is limited evidence that nitrate, a common contaminant in drinking water, increases the risk of childhood cancers. Our objective was to examine this association in Denmark. Methods: We conducted a nationwide case-control study based on all singletons liveborn to Danish-born parents from 1991 to 2015 (N = 1,219,140) that included 596 leukemias, 180 lymphomas, and 310 central nervous system cancers (CNC) who were 25 mg/L nitrate) was observed for preconception (OR = 1.82, 95%CI:1.09 to 3.04), prenatal (OR = 1.65, 95%CI:0.97 to 2.81), and postnatal exposure (OR = 1.48, 95% CI:0.82 to 2.68) in fully adjusted models. There was also some evidence of an exposure-response in models of continuous nitrate exposure and CNC. Conclusions: Our findings provide some evidence that exposure to nitrate from drinking water may increase the risk of childhood CNC cancer, but not leukemia or lymphoma.
AB - Background: There is limited evidence that nitrate, a common contaminant in drinking water, increases the risk of childhood cancers. Our objective was to examine this association in Denmark. Methods: We conducted a nationwide case-control study based on all singletons liveborn to Danish-born parents from 1991 to 2015 (N = 1,219,140) that included 596 leukemias, 180 lymphomas, and 310 central nervous system cancers (CNC) who were 25 mg/L nitrate) was observed for preconception (OR = 1.82, 95%CI:1.09 to 3.04), prenatal (OR = 1.65, 95%CI:0.97 to 2.81), and postnatal exposure (OR = 1.48, 95% CI:0.82 to 2.68) in fully adjusted models. There was also some evidence of an exposure-response in models of continuous nitrate exposure and CNC. Conclusions: Our findings provide some evidence that exposure to nitrate from drinking water may increase the risk of childhood CNC cancer, but not leukemia or lymphoma.
KW - Nitrate
KW - Drinking water
KW - Childhood leukemia
KW - Lymphoma and central nervous system cancer
KW - N-NITROSO COMPOUNDS
KW - BRAIN-TUMORS
KW - GROUNDWATER
U2 - 10.1016/j.envint.2021.106613
DO - 10.1016/j.envint.2021.106613
M3 - Journal article
C2 - 33965769
VL - 155
JO - Environment international
JF - Environment international
SN - 0160-4120
M1 - 106613
ER -
ID: 275817740