Familial clustering of myocardial infarction in first-degree relatives: a nationwide study

Research output: Contribution to journalJournal articlepeer-review

Standard

Familial clustering of myocardial infarction in first-degree relatives : a nationwide study. / Nielsen, Mia; Andersson, Charlotte; Gerds, Thomas A; Andersen, Per Kragh; Jensen, Thomas Bo; Køber, Lars; Gislason, Gunnar; Torp-Pedersen, Christian.

In: European Heart Journal (Online), Vol. 34, No. 16, 2013, p. 1198-1203.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Nielsen, M, Andersson, C, Gerds, TA, Andersen, PK, Jensen, TB, Køber, L, Gislason, G & Torp-Pedersen, C 2013, 'Familial clustering of myocardial infarction in first-degree relatives: a nationwide study', European Heart Journal (Online), vol. 34, no. 16, pp. 1198-1203. https://doi.org/10.1093/eurheartj/ehs475

APA

Nielsen, M., Andersson, C., Gerds, T. A., Andersen, P. K., Jensen, T. B., Køber, L., Gislason, G., & Torp-Pedersen, C. (2013). Familial clustering of myocardial infarction in first-degree relatives: a nationwide study. European Heart Journal (Online), 34(16), 1198-1203. https://doi.org/10.1093/eurheartj/ehs475

Vancouver

Nielsen M, Andersson C, Gerds TA, Andersen PK, Jensen TB, Køber L et al. Familial clustering of myocardial infarction in first-degree relatives: a nationwide study. European Heart Journal (Online). 2013;34(16):1198-1203. https://doi.org/10.1093/eurheartj/ehs475

Author

Nielsen, Mia ; Andersson, Charlotte ; Gerds, Thomas A ; Andersen, Per Kragh ; Jensen, Thomas Bo ; Køber, Lars ; Gislason, Gunnar ; Torp-Pedersen, Christian. / Familial clustering of myocardial infarction in first-degree relatives : a nationwide study. In: European Heart Journal (Online). 2013 ; Vol. 34, No. 16. pp. 1198-1203.

Bibtex

@article{792d8c3884564b4f9d1ff37c1c570304,
title = "Familial clustering of myocardial infarction in first-degree relatives: a nationwide study",
abstract = "Aims Family history is an established risk factor for myocardial infarction (MI), but it is not clear how this risk changes with number and gender of first-degree relatives with MI. We used the entire Danish population to examine the importance of MI in siblings and parents.Methods and results This study is a retrospective nationwide register-based cohort study including registered relatives to all Danish citizens diagnosed with MI in the period 1978–2010. In the entire Danish population we identified siblings to 7552 patients with a first-time MI. The rate ratios (RR) calculated by Poisson models showed an RR of 4.30 (95% confidence interval 3.53–5.23) for siblings of a patient with MI. Children of parents with MI also showed high risk: for children of a maternal case RR 2.40 (2.20–2.60), and of a paternal case RR 1.98 (1.98–2.09), respectively; P value for gender interaction <0.0001. A paternal case with MI at an age <50 years was associated with an RR of 3.30 (2.92–3.72) while a case >50 years was associated with a risk of 1.83 (1.73–1.93). For maternal cases below and above 50 years of age the risks were 3.23 (2.56–4.10) and 2.31 (2.11–2.52), respectively.Conclusion First-degree relatives of a patient with myocardial infarction themselves have a substantial higher risk of myocardial infarction. The risk is particularly elevated when the MI case is the mother or a sibling, and when the MI case has the infarction before the age of 50 years.",
keywords = "Faculty of Health and Medical Sciences, Familial clustering, Myocardial infarction, First-degree relatives",
author = "Mia Nielsen and Charlotte Andersson and Gerds, {Thomas A} and Andersen, {Per Kragh} and Jensen, {Thomas Bo} and Lars K{\o}ber and Gunnar Gislason and Christian Torp-Pedersen",
year = "2013",
doi = "10.1093/eurheartj/ehs475",
language = "English",
volume = "34",
pages = "1198--1203",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "16",

}

RIS

TY - JOUR

T1 - Familial clustering of myocardial infarction in first-degree relatives

T2 - a nationwide study

AU - Nielsen, Mia

AU - Andersson, Charlotte

AU - Gerds, Thomas A

AU - Andersen, Per Kragh

AU - Jensen, Thomas Bo

AU - Køber, Lars

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

PY - 2013

Y1 - 2013

N2 - Aims Family history is an established risk factor for myocardial infarction (MI), but it is not clear how this risk changes with number and gender of first-degree relatives with MI. We used the entire Danish population to examine the importance of MI in siblings and parents.Methods and results This study is a retrospective nationwide register-based cohort study including registered relatives to all Danish citizens diagnosed with MI in the period 1978–2010. In the entire Danish population we identified siblings to 7552 patients with a first-time MI. The rate ratios (RR) calculated by Poisson models showed an RR of 4.30 (95% confidence interval 3.53–5.23) for siblings of a patient with MI. Children of parents with MI also showed high risk: for children of a maternal case RR 2.40 (2.20–2.60), and of a paternal case RR 1.98 (1.98–2.09), respectively; P value for gender interaction <0.0001. A paternal case with MI at an age <50 years was associated with an RR of 3.30 (2.92–3.72) while a case >50 years was associated with a risk of 1.83 (1.73–1.93). For maternal cases below and above 50 years of age the risks were 3.23 (2.56–4.10) and 2.31 (2.11–2.52), respectively.Conclusion First-degree relatives of a patient with myocardial infarction themselves have a substantial higher risk of myocardial infarction. The risk is particularly elevated when the MI case is the mother or a sibling, and when the MI case has the infarction before the age of 50 years.

AB - Aims Family history is an established risk factor for myocardial infarction (MI), but it is not clear how this risk changes with number and gender of first-degree relatives with MI. We used the entire Danish population to examine the importance of MI in siblings and parents.Methods and results This study is a retrospective nationwide register-based cohort study including registered relatives to all Danish citizens diagnosed with MI in the period 1978–2010. In the entire Danish population we identified siblings to 7552 patients with a first-time MI. The rate ratios (RR) calculated by Poisson models showed an RR of 4.30 (95% confidence interval 3.53–5.23) for siblings of a patient with MI. Children of parents with MI also showed high risk: for children of a maternal case RR 2.40 (2.20–2.60), and of a paternal case RR 1.98 (1.98–2.09), respectively; P value for gender interaction <0.0001. A paternal case with MI at an age <50 years was associated with an RR of 3.30 (2.92–3.72) while a case >50 years was associated with a risk of 1.83 (1.73–1.93). For maternal cases below and above 50 years of age the risks were 3.23 (2.56–4.10) and 2.31 (2.11–2.52), respectively.Conclusion First-degree relatives of a patient with myocardial infarction themselves have a substantial higher risk of myocardial infarction. The risk is particularly elevated when the MI case is the mother or a sibling, and when the MI case has the infarction before the age of 50 years.

KW - Faculty of Health and Medical Sciences

KW - Familial clustering

KW - Myocardial infarction

KW - First-degree relatives

U2 - 10.1093/eurheartj/ehs475

DO - 10.1093/eurheartj/ehs475

M3 - Journal article

C2 - 23297314

VL - 34

SP - 1198

EP - 1203

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 16

ER -

ID: 117435601