Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone

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Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. / Zutinic, Ana; Pijl, Hanno; Ballieux, Bart E; Roelfsema, Ferdinand; Westendorp, Rudi G J; Blauw, Gerard J; van Heemst, Diana.

In: The Journal of clinical endocrinology and metabolism, Vol. 105, No. 7, 01.07.2020, p. e2572–e2580.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Zutinic, A, Pijl, H, Ballieux, BE, Roelfsema, F, Westendorp, RGJ, Blauw, GJ & van Heemst, D 2020, 'Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone', The Journal of clinical endocrinology and metabolism, vol. 105, no. 7, pp. e2572–e2580. https://doi.org/10.1210/clinem/dgaa195

APA

Zutinic, A., Pijl, H., Ballieux, B. E., Roelfsema, F., Westendorp, R. G. J., Blauw, G. J., & van Heemst, D. (2020). Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. The Journal of clinical endocrinology and metabolism, 105(7), e2572–e2580. https://doi.org/10.1210/clinem/dgaa195

Vancouver

Zutinic A, Pijl H, Ballieux BE, Roelfsema F, Westendorp RGJ, Blauw GJ et al. Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. The Journal of clinical endocrinology and metabolism. 2020 Jul 1;105(7):e2572–e2580. https://doi.org/10.1210/clinem/dgaa195

Author

Zutinic, Ana ; Pijl, Hanno ; Ballieux, Bart E ; Roelfsema, Ferdinand ; Westendorp, Rudi G J ; Blauw, Gerard J ; van Heemst, Diana. / Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. In: The Journal of clinical endocrinology and metabolism. 2020 ; Vol. 105, No. 7. pp. e2572–e2580.

Bibtex

@article{d04019f4c9a84ec58ed201e0c4eb6076,
title = "Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone",
abstract = "CONTEXT: Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown.OBJECTIVE: We hypothesized that the thyroid gland of members from long-lived families are less responsive to TSH stimulation, thereby requiring higher circulating TSH levels to maintain adequate TH levels.METHODS: We performed a case-control intervention study with a single intramuscular (gluteal) injection with 0.1 mg recombinant human TSH in a subgroup of 14 F2-LLS and 15 similarly aged F2-Con. They were followed for 4 days. No serious adverse events were reported. For analyses, we compared time trajectories of TSH and TH, and the ratio of TH to TSH using area under the curve (AUC) calculations.RESULTS: The AUC free T4/AUC TSH ratio was significantly lower in F2-LLS than in F2-Con (estimated mean [95% confidence interval] 1.6 [1.2-1.9] and 2.2 [1.9-2.6], respectively, P = 0.01). The AUC thyroglobulin/AUC TSH ratio was also lower in F2-LLS than in F2-Con (median [interquartile range] 2.1 [1.4-3.6] and 3.2 [2.7-7.4], respectively, P = 0.04). We observed the same trend with the AUC free T3/AUC TSH ratio, although the difference was not statistically significant (estimated mean [95% confidence interval] 0.6 [0.4-0.7] and 0.7 [0.6-0.8], respectively, P = 0.07).CONCLUSIONS: The present findings show that members of long-living families have a lower thyroid responsivity to TSH compared with their partners.",
keywords = "Aged, Case-Control Studies, Female, Humans, Longevity/genetics, Male, Middle Aged, Recombinant Proteins/pharmacology, Thyroid Gland/drug effects, Thyrotropin/blood, Thyroxine/blood, Triiodothyronine/blood",
author = "Ana Zutinic and Hanno Pijl and Ballieux, {Bart E} and Ferdinand Roelfsema and Westendorp, {Rudi G J} and Blauw, {Gerard J} and {van Heemst}, Diana",
note = "{\textcopyright} Endocrine Society 2020.",
year = "2020",
month = jul,
day = "1",
doi = "10.1210/clinem/dgaa195",
language = "English",
volume = "105",
pages = "e2572–e2580",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone

AU - Zutinic, Ana

AU - Pijl, Hanno

AU - Ballieux, Bart E

AU - Roelfsema, Ferdinand

AU - Westendorp, Rudi G J

AU - Blauw, Gerard J

AU - van Heemst, Diana

N1 - © Endocrine Society 2020.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - CONTEXT: Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown.OBJECTIVE: We hypothesized that the thyroid gland of members from long-lived families are less responsive to TSH stimulation, thereby requiring higher circulating TSH levels to maintain adequate TH levels.METHODS: We performed a case-control intervention study with a single intramuscular (gluteal) injection with 0.1 mg recombinant human TSH in a subgroup of 14 F2-LLS and 15 similarly aged F2-Con. They were followed for 4 days. No serious adverse events were reported. For analyses, we compared time trajectories of TSH and TH, and the ratio of TH to TSH using area under the curve (AUC) calculations.RESULTS: The AUC free T4/AUC TSH ratio was significantly lower in F2-LLS than in F2-Con (estimated mean [95% confidence interval] 1.6 [1.2-1.9] and 2.2 [1.9-2.6], respectively, P = 0.01). The AUC thyroglobulin/AUC TSH ratio was also lower in F2-LLS than in F2-Con (median [interquartile range] 2.1 [1.4-3.6] and 3.2 [2.7-7.4], respectively, P = 0.04). We observed the same trend with the AUC free T3/AUC TSH ratio, although the difference was not statistically significant (estimated mean [95% confidence interval] 0.6 [0.4-0.7] and 0.7 [0.6-0.8], respectively, P = 0.07).CONCLUSIONS: The present findings show that members of long-living families have a lower thyroid responsivity to TSH compared with their partners.

AB - CONTEXT: Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown.OBJECTIVE: We hypothesized that the thyroid gland of members from long-lived families are less responsive to TSH stimulation, thereby requiring higher circulating TSH levels to maintain adequate TH levels.METHODS: We performed a case-control intervention study with a single intramuscular (gluteal) injection with 0.1 mg recombinant human TSH in a subgroup of 14 F2-LLS and 15 similarly aged F2-Con. They were followed for 4 days. No serious adverse events were reported. For analyses, we compared time trajectories of TSH and TH, and the ratio of TH to TSH using area under the curve (AUC) calculations.RESULTS: The AUC free T4/AUC TSH ratio was significantly lower in F2-LLS than in F2-Con (estimated mean [95% confidence interval] 1.6 [1.2-1.9] and 2.2 [1.9-2.6], respectively, P = 0.01). The AUC thyroglobulin/AUC TSH ratio was also lower in F2-LLS than in F2-Con (median [interquartile range] 2.1 [1.4-3.6] and 3.2 [2.7-7.4], respectively, P = 0.04). We observed the same trend with the AUC free T3/AUC TSH ratio, although the difference was not statistically significant (estimated mean [95% confidence interval] 0.6 [0.4-0.7] and 0.7 [0.6-0.8], respectively, P = 0.07).CONCLUSIONS: The present findings show that members of long-living families have a lower thyroid responsivity to TSH compared with their partners.

KW - Aged

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Longevity/genetics

KW - Male

KW - Middle Aged

KW - Recombinant Proteins/pharmacology

KW - Thyroid Gland/drug effects

KW - Thyrotropin/blood

KW - Thyroxine/blood

KW - Triiodothyronine/blood

U2 - 10.1210/clinem/dgaa195

DO - 10.1210/clinem/dgaa195

M3 - Journal article

C2 - 32303766

VL - 105

SP - e2572–e2580

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -

ID: 258781153