Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship

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Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship. / Jansen, Steffy W; Roelfsema, Ferdinand; van der Spoel, Evie; Akintola, Abimbola A; Postmus, Iris; Ballieux, Bart E; Slagboom, P Eline; Cobbaert, Christa M; van der Grond, Jeroen; Westendorp, Rudi G; Pijl, Hanno; van Heemst, Diana.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 10, 10.2015, p. 3806-3813.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jansen, SW, Roelfsema, F, van der Spoel, E, Akintola, AA, Postmus, I, Ballieux, BE, Slagboom, PE, Cobbaert, CM, van der Grond, J, Westendorp, RG, Pijl, H & van Heemst, D 2015, 'Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 10, pp. 3806-3813. https://doi.org/10.1210/jc.2015-2624

APA

Jansen, S. W., Roelfsema, F., van der Spoel, E., Akintola, A. A., Postmus, I., Ballieux, B. E., ... van Heemst, D. (2015). Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship. Journal of Clinical Endocrinology and Metabolism, 100(10), 3806-3813. https://doi.org/10.1210/jc.2015-2624

Vancouver

Jansen SW, Roelfsema F, van der Spoel E, Akintola AA, Postmus I, Ballieux BE et al. Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship. Journal of Clinical Endocrinology and Metabolism. 2015 Oct;100(10):3806-3813. https://doi.org/10.1210/jc.2015-2624

Author

Jansen, Steffy W ; Roelfsema, Ferdinand ; van der Spoel, Evie ; Akintola, Abimbola A ; Postmus, Iris ; Ballieux, Bart E ; Slagboom, P Eline ; Cobbaert, Christa M ; van der Grond, Jeroen ; Westendorp, Rudi G ; Pijl, Hanno ; van Heemst, Diana. / Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 10. pp. 3806-3813.

Bibtex

@article{3ad476e0b4f1412f9f3c6648a0ea5621,
title = "Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship",
abstract = "CONTEXT: Longevity is associated with changes in circulating levels of thyroid hormone (TH) and/or TSH in animals and humans, but underlying mechanisms remain elusive.OBJECTIVE: We explored in 38 offspring of nonagenarian participants from the Leiden Longevity Study, who are enriched for longevity and in their partners, ultradian and circadian rhythmicity of TSH, temporal relationship, and feedback and forward interplay between TSH and TH.METHODS: We collected blood samples every 10 minutes for 24 hours for TSH and TH profiles. We used a deconvolution analysis to estimate basal (nonpulsatile), pulsatile, and other secretion parameters to characterize ultradian rhythmicity and locally weighted polynomial regression of TSH to assess circadian rhythmicity. A cross-correlation analysis was used to investigate the temporal relationship between TSH and TH and cross-approximate entropy to assess feedback and forward interplay between TSH and TH.RESULTS: Compared with partners, offspring displayed higher mean (95{\%} confidence interval [CI]) basal TSH secretion (34.3 [95{\%} CI 27.2-43.1] mU/L per 24 hours vs 18.5 [95{\%} CI 14.4-23.7] mU/L per 24 hours, P = .001) but no differences in ultradian or circadian properties of TSH. The temporal relationship between TSH and free T3 at zero delay was higher in offspring (0.48 ± 0.2) compared with partners (0.26 ± 0.4) (P = .05), but the feedback and forward interplay between TSH and TH did not differ.CONCLUSIONS: Familial longevity is associated with increased basal TSH secretion and a strong temporal relationship between TSH and free T3 but not with differences in ultradian or circadian TSH rhythmicity or feedback and forward interplay between TSH and TH.",
author = "Jansen, {Steffy W} and Ferdinand Roelfsema and {van der Spoel}, Evie and Akintola, {Abimbola A} and Iris Postmus and Ballieux, {Bart E} and Slagboom, {P Eline} and Cobbaert, {Christa M} and {van der Grond}, Jeroen and Westendorp, {Rudi G} and Hanno Pijl and {van Heemst}, Diana",
year = "2015",
month = "10",
doi = "10.1210/jc.2015-2624",
language = "English",
volume = "100",
pages = "3806--3813",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship

AU - Jansen, Steffy W

AU - Roelfsema, Ferdinand

AU - van der Spoel, Evie

AU - Akintola, Abimbola A

AU - Postmus, Iris

AU - Ballieux, Bart E

AU - Slagboom, P Eline

AU - Cobbaert, Christa M

AU - van der Grond, Jeroen

AU - Westendorp, Rudi G

AU - Pijl, Hanno

AU - van Heemst, Diana

PY - 2015/10

Y1 - 2015/10

N2 - CONTEXT: Longevity is associated with changes in circulating levels of thyroid hormone (TH) and/or TSH in animals and humans, but underlying mechanisms remain elusive.OBJECTIVE: We explored in 38 offspring of nonagenarian participants from the Leiden Longevity Study, who are enriched for longevity and in their partners, ultradian and circadian rhythmicity of TSH, temporal relationship, and feedback and forward interplay between TSH and TH.METHODS: We collected blood samples every 10 minutes for 24 hours for TSH and TH profiles. We used a deconvolution analysis to estimate basal (nonpulsatile), pulsatile, and other secretion parameters to characterize ultradian rhythmicity and locally weighted polynomial regression of TSH to assess circadian rhythmicity. A cross-correlation analysis was used to investigate the temporal relationship between TSH and TH and cross-approximate entropy to assess feedback and forward interplay between TSH and TH.RESULTS: Compared with partners, offspring displayed higher mean (95% confidence interval [CI]) basal TSH secretion (34.3 [95% CI 27.2-43.1] mU/L per 24 hours vs 18.5 [95% CI 14.4-23.7] mU/L per 24 hours, P = .001) but no differences in ultradian or circadian properties of TSH. The temporal relationship between TSH and free T3 at zero delay was higher in offspring (0.48 ± 0.2) compared with partners (0.26 ± 0.4) (P = .05), but the feedback and forward interplay between TSH and TH did not differ.CONCLUSIONS: Familial longevity is associated with increased basal TSH secretion and a strong temporal relationship between TSH and free T3 but not with differences in ultradian or circadian TSH rhythmicity or feedback and forward interplay between TSH and TH.

AB - CONTEXT: Longevity is associated with changes in circulating levels of thyroid hormone (TH) and/or TSH in animals and humans, but underlying mechanisms remain elusive.OBJECTIVE: We explored in 38 offspring of nonagenarian participants from the Leiden Longevity Study, who are enriched for longevity and in their partners, ultradian and circadian rhythmicity of TSH, temporal relationship, and feedback and forward interplay between TSH and TH.METHODS: We collected blood samples every 10 minutes for 24 hours for TSH and TH profiles. We used a deconvolution analysis to estimate basal (nonpulsatile), pulsatile, and other secretion parameters to characterize ultradian rhythmicity and locally weighted polynomial regression of TSH to assess circadian rhythmicity. A cross-correlation analysis was used to investigate the temporal relationship between TSH and TH and cross-approximate entropy to assess feedback and forward interplay between TSH and TH.RESULTS: Compared with partners, offspring displayed higher mean (95% confidence interval [CI]) basal TSH secretion (34.3 [95% CI 27.2-43.1] mU/L per 24 hours vs 18.5 [95% CI 14.4-23.7] mU/L per 24 hours, P = .001) but no differences in ultradian or circadian properties of TSH. The temporal relationship between TSH and free T3 at zero delay was higher in offspring (0.48 ± 0.2) compared with partners (0.26 ± 0.4) (P = .05), but the feedback and forward interplay between TSH and TH did not differ.CONCLUSIONS: Familial longevity is associated with increased basal TSH secretion and a strong temporal relationship between TSH and free T3 but not with differences in ultradian or circadian TSH rhythmicity or feedback and forward interplay between TSH and TH.

U2 - 10.1210/jc.2015-2624

DO - 10.1210/jc.2015-2624

M3 - Journal article

C2 - 26230295

VL - 100

SP - 3806

EP - 3813

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -

ID: 146207342