Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring

Research output: Contribution to journalJournal articlepeer-review

Standard

Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. / Dreier, Julie Werenberg; Andersen, Anne-Marie Nybo; Hvolby, Allan; Garne, Ester; Andersen, Per Kragh; Berg-Beckhoff, Gabriele.

In: Journal of Child Psychology and Psychiatry, Vol. 57, No. 4, 04.2016, p. 540-548.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Dreier, JW, Andersen, A-MN, Hvolby, A, Garne, E, Andersen, PK & Berg-Beckhoff, G 2016, 'Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring', Journal of Child Psychology and Psychiatry, vol. 57, no. 4, pp. 540-548. https://doi.org/10.1111/jcpp.12480

APA

Dreier, J. W., Andersen, A-M. N., Hvolby, A., Garne, E., Andersen, P. K., & Berg-Beckhoff, G. (2016). Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. Journal of Child Psychology and Psychiatry, 57(4), 540-548. https://doi.org/10.1111/jcpp.12480

Vancouver

Dreier JW, Andersen A-MN, Hvolby A, Garne E, Andersen PK, Berg-Beckhoff G. Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. Journal of Child Psychology and Psychiatry. 2016 Apr;57(4):540-548. https://doi.org/10.1111/jcpp.12480

Author

Dreier, Julie Werenberg ; Andersen, Anne-Marie Nybo ; Hvolby, Allan ; Garne, Ester ; Andersen, Per Kragh ; Berg-Beckhoff, Gabriele. / Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. In: Journal of Child Psychology and Psychiatry. 2016 ; Vol. 57, No. 4. pp. 540-548.

Bibtex

@article{2f83a1df053c4baea57c658fe408d6c2,
title = "Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring",
abstract = "Background: Fever and infections are common events during pregnancy, and have been shown to be associated with neurodevelopmental impairment in the offspring. The evidence in relation to attention deficit/hyperactivity disorder (ADHD) is, however, nonexistent for fever and limited for infections. The aim of this study was therefore to investigate the impact of these exposures on the occurrence of ADHD in the offspring, considering gestational timing as well as intensity of exposure.Methods:The study was conducted within the Danish National Birth Cohort, using data on 89,146 pregnancies enrolled during 1996–2002. Exposure to fever and infections were assessed prospectively in two computer-assisted telephone interviews during pregnancy and ADHD status in the child was determined using registry information from three nation-wide patient and prescription registers. Stratified Cox regressions were used to calculate adjusted hazard ratios of ADHD occurrence.Results:The analyses revealed no overall association between maternal exposure to fever or infections and ADHD in the offspring [adjusted hazard ratio (aHR): 1.03, 95% confidence interval (CI): 0.93–1.13 and aHR: 1.01, 95% CI: 0.92–1.11]. When the exposures were considered during specific gestational periods, increased rates of ADHD were observed following fever in gestational weeks 9–12 (aHR: 1.33, 95% CI: 1.12–1.58), and genitourinary infections in weeks 33–36 (aHR: 1.60, 95% CI: 1.13–2.26).Conclusions:Although no overall adverse association between fever and infections in pregnancy and ADHD in the offspring was found, the analyses indicated that exposures during specific time windows of the pregnancy could be associated with increased ADHD occurrence.",
keywords = "ADHD, prenatal, epidemiologic studies",
author = "Dreier, {Julie Werenberg} and Andersen, {Anne-Marie Nybo} and Allan Hvolby and Ester Garne and Andersen, {Per Kragh} and Gabriele Berg-Beckhoff",
year = "2016",
month = apr,
doi = "10.1111/jcpp.12480",
language = "English",
volume = "57",
pages = "540--548",
journal = "Journal of Child Psychology & Psychiatry",
issn = "0021-9630",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring

AU - Dreier, Julie Werenberg

AU - Andersen, Anne-Marie Nybo

AU - Hvolby, Allan

AU - Garne, Ester

AU - Andersen, Per Kragh

AU - Berg-Beckhoff, Gabriele

PY - 2016/4

Y1 - 2016/4

N2 - Background: Fever and infections are common events during pregnancy, and have been shown to be associated with neurodevelopmental impairment in the offspring. The evidence in relation to attention deficit/hyperactivity disorder (ADHD) is, however, nonexistent for fever and limited for infections. The aim of this study was therefore to investigate the impact of these exposures on the occurrence of ADHD in the offspring, considering gestational timing as well as intensity of exposure.Methods:The study was conducted within the Danish National Birth Cohort, using data on 89,146 pregnancies enrolled during 1996–2002. Exposure to fever and infections were assessed prospectively in two computer-assisted telephone interviews during pregnancy and ADHD status in the child was determined using registry information from three nation-wide patient and prescription registers. Stratified Cox regressions were used to calculate adjusted hazard ratios of ADHD occurrence.Results:The analyses revealed no overall association between maternal exposure to fever or infections and ADHD in the offspring [adjusted hazard ratio (aHR): 1.03, 95% confidence interval (CI): 0.93–1.13 and aHR: 1.01, 95% CI: 0.92–1.11]. When the exposures were considered during specific gestational periods, increased rates of ADHD were observed following fever in gestational weeks 9–12 (aHR: 1.33, 95% CI: 1.12–1.58), and genitourinary infections in weeks 33–36 (aHR: 1.60, 95% CI: 1.13–2.26).Conclusions:Although no overall adverse association between fever and infections in pregnancy and ADHD in the offspring was found, the analyses indicated that exposures during specific time windows of the pregnancy could be associated with increased ADHD occurrence.

AB - Background: Fever and infections are common events during pregnancy, and have been shown to be associated with neurodevelopmental impairment in the offspring. The evidence in relation to attention deficit/hyperactivity disorder (ADHD) is, however, nonexistent for fever and limited for infections. The aim of this study was therefore to investigate the impact of these exposures on the occurrence of ADHD in the offspring, considering gestational timing as well as intensity of exposure.Methods:The study was conducted within the Danish National Birth Cohort, using data on 89,146 pregnancies enrolled during 1996–2002. Exposure to fever and infections were assessed prospectively in two computer-assisted telephone interviews during pregnancy and ADHD status in the child was determined using registry information from three nation-wide patient and prescription registers. Stratified Cox regressions were used to calculate adjusted hazard ratios of ADHD occurrence.Results:The analyses revealed no overall association between maternal exposure to fever or infections and ADHD in the offspring [adjusted hazard ratio (aHR): 1.03, 95% confidence interval (CI): 0.93–1.13 and aHR: 1.01, 95% CI: 0.92–1.11]. When the exposures were considered during specific gestational periods, increased rates of ADHD were observed following fever in gestational weeks 9–12 (aHR: 1.33, 95% CI: 1.12–1.58), and genitourinary infections in weeks 33–36 (aHR: 1.60, 95% CI: 1.13–2.26).Conclusions:Although no overall adverse association between fever and infections in pregnancy and ADHD in the offspring was found, the analyses indicated that exposures during specific time windows of the pregnancy could be associated with increased ADHD occurrence.

KW - ADHD

KW - prenatal

KW - epidemiologic studies

U2 - 10.1111/jcpp.12480

DO - 10.1111/jcpp.12480

M3 - Journal article

C2 - 26530451

VL - 57

SP - 540

EP - 548

JO - Journal of Child Psychology & Psychiatry

JF - Journal of Child Psychology & Psychiatry

SN - 0021-9630

IS - 4

ER -

ID: 173741606