First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization
Research output: Contribution to journal › Journal article › Research › peer-review
The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.
|Publication status||Published - 2008|
- Former Faculty of Pharmaceutical Sciences