Fish, n-3 fatty acids, and cardiovascular diseases in women of reproductive age: a prospective study in a large national cohort
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Fish, n-3 fatty acids, and cardiovascular diseases in women of reproductive age : a prospective study in a large national cohort. / Strøm, Marin; Halldorsson, Thorhallur I; Mortensen, Erik L; Torp-Pedersen, Christian; Olsen, Sjurdur F.
In: Hypertension, Vol. 59, No. 1, 2012, p. 36-43.Research output: Contribution to journal › Journal article › peer-review
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T1 - Fish, n-3 fatty acids, and cardiovascular diseases in women of reproductive age
T2 - a prospective study in a large national cohort
AU - Strøm, Marin
AU - Halldorsson, Thorhallur I
AU - Mortensen, Erik L
AU - Torp-Pedersen, Christian
AU - Olsen, Sjurdur F
PY - 2012
Y1 - 2012
N2 - Previous studies have indicated a protective effect of long-chain n-3 polyunsaturated fatty acids (LCn3FAs) against cardiovascular disease; however, women are underrepresented in cardiovascular research. The aim of this study was to explore the association between intake of LCn3FAs and the risk of cardiovascular disease in a large prospective cohort of young women (mean age at baseline: 29.9 years [range: 15.7-46.9]). Exposure information on 48 627 women from the Danish National Birth Cohort was linked to the Danish National Patients Registry for information on events of hypertensive, cerebrovascular, and ischemic heart disease used to define a combined measure of cardiovascular diseases. Intake of fish and LCn3FAs was assessed by a food-frequency questionnaire and telephone interviews. During follow-up (1996-2008; median: 8 years), 577 events of cardiovascular disease were identified. Low LCn3FA intake was associated with an increased risk of cardiovascular disease (adjusted hazard ratio for women in lowest versus highest LCn3FA intake group: 1.91 [95% CI: 1.26-2.90]). Restricting the sample to women who had consistently reported similar frequencies of fish intake across 3 different dietary assessment occasions tended to strengthen the relationship (hazard ratio for lowest versus highest intake: 2.91 [95% CI: 1.45-5.85]). Furthermore, the observed associations were consistent in supplementary analyses where LCn3FA intake was averaged across the 3 dietary assessment occasions, and the associations were persistent for all 3 of the individual outcomes. Our findings based on a large prospective cohort of relatively young and initially healthy women indicated that little or no intake of fish and LCn3FAs was associated with an increased risk of cardiovascular disease.
AB - Previous studies have indicated a protective effect of long-chain n-3 polyunsaturated fatty acids (LCn3FAs) against cardiovascular disease; however, women are underrepresented in cardiovascular research. The aim of this study was to explore the association between intake of LCn3FAs and the risk of cardiovascular disease in a large prospective cohort of young women (mean age at baseline: 29.9 years [range: 15.7-46.9]). Exposure information on 48 627 women from the Danish National Birth Cohort was linked to the Danish National Patients Registry for information on events of hypertensive, cerebrovascular, and ischemic heart disease used to define a combined measure of cardiovascular diseases. Intake of fish and LCn3FAs was assessed by a food-frequency questionnaire and telephone interviews. During follow-up (1996-2008; median: 8 years), 577 events of cardiovascular disease were identified. Low LCn3FA intake was associated with an increased risk of cardiovascular disease (adjusted hazard ratio for women in lowest versus highest LCn3FA intake group: 1.91 [95% CI: 1.26-2.90]). Restricting the sample to women who had consistently reported similar frequencies of fish intake across 3 different dietary assessment occasions tended to strengthen the relationship (hazard ratio for lowest versus highest intake: 2.91 [95% CI: 1.45-5.85]). Furthermore, the observed associations were consistent in supplementary analyses where LCn3FA intake was averaged across the 3 dietary assessment occasions, and the associations were persistent for all 3 of the individual outcomes. Our findings based on a large prospective cohort of relatively young and initially healthy women indicated that little or no intake of fish and LCn3FAs was associated with an increased risk of cardiovascular disease.
KW - Adolescent
KW - Adult
KW - Animals
KW - Cerebrovascular Disorders
KW - Cohort Studies
KW - Denmark
KW - Fatty Acids, Omega-3
KW - Female
KW - Fishes
KW - Follow-Up Studies
KW - Humans
KW - Hypertension
KW - Middle Aged
KW - Myocardial Ischemia
KW - Nutrition Surveys
KW - Prospective Studies
KW - Registries
KW - Risk Factors
KW - Seafood
KW - Young Adult
U2 - 10.1161/HYPERTENSIONAHA.111.179382
DO - 10.1161/HYPERTENSIONAHA.111.179382
M3 - Journal article
C2 - 22146511
VL - 59
SP - 36
EP - 43
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 1
ER -
ID: 38186697