TY - GEN

T1 - Fish oil supplementation during pregnancy and offspring risk of attention deficit/hyperactivity disorder and depression

AU - Strøm, Marin

AU - Maslova, E.

AU - Hansen, S.

AU - Mortensen, Erik Lykke

AU - Olsen, Sjurdur F.

PY - 2013

Y1 - 2013

N2 - M STRØM1, E MASLOVA1, S HANSEN1,EL MORTENSEN2 & SF OLSEN1,31Centre for Fetal Programming, Department ofEpidemiology Research, Statens Serum Institut,Copenhagen, Denmark, 2Institute of Public Health andCenter for Healthy Aging, University of Copenhagen,Copenhagen, Denmark, and 3Department of Nutrition,Harvard School of Public Health, Boston, USABackground: Fish oil contains docosahexaenoic acid(DHA), the most abundant fatty acid in the cerebral cortex.Previous studies have suggested beneficial effects ofmaternal DHA intake on brain development and psychopathologyin the offspring.Objective: To examine the effect of fish oil supplementationin pregnancy on offspring risk of attention deficit/hyperactivity disorder (ADHD) and depression.Methods: We used data from 397 and 654 singleton offspringof mothers who were randomized to fish oil (providing1 g/day of DHA) or olive oil during pregnancy asparticipants in: the RCT90, a single center trial enrollingnormal pregnancies in 1990, and FOTIP, a multicentertrial enrolling high-risk pregnancies during 1990–1996.We used definitions of ADHD and depression basedon ICD-10 codes and drug dispensary data, using informationon first prescription/hospital contact as a proxyfor ADHD and depression, respectively. We performedintention-to-treat analysis and report odds ratios (ORs)and 95% CI comparing the two intervention groups.Results: There were 17 and 35 cases of ADHD among offspringto participants in RCT90 and FOTIP, respectively;for depression corresponding numbers were 46 and 31. Inboth trials there was a reduced risk of ADHD in the fishoil groups, but this was not statistically significant[OR = 0.73(95% CI: 0.27;1.97), OR = 0.75(95% CI:0.38;1.50), respectively]. For depression, in the RCT90there was a non-significant reduced risk in the fish oilgroup, [OR = 0.71(95% CI: 0.38;1.33)]; whereas the ORin the FOTIP was approaching unity [OR = 1.09 (95%CI0.53;2.25)].Conclusions: We found no statistically significant effectsof fish oil supplementation during pregnancy on ADHDor depression in the offspring up to the age of 14–20.However, the results regarding ADHD point in the directionof a beneficial effect. The next step will be to poolthe two trials in a random effects model to test this in apopulation with better statistical power.

AB - M STRØM1, E MASLOVA1, S HANSEN1,EL MORTENSEN2 & SF OLSEN1,31Centre for Fetal Programming, Department ofEpidemiology Research, Statens Serum Institut,Copenhagen, Denmark, 2Institute of Public Health andCenter for Healthy Aging, University of Copenhagen,Copenhagen, Denmark, and 3Department of Nutrition,Harvard School of Public Health, Boston, USABackground: Fish oil contains docosahexaenoic acid(DHA), the most abundant fatty acid in the cerebral cortex.Previous studies have suggested beneficial effects ofmaternal DHA intake on brain development and psychopathologyin the offspring.Objective: To examine the effect of fish oil supplementationin pregnancy on offspring risk of attention deficit/hyperactivity disorder (ADHD) and depression.Methods: We used data from 397 and 654 singleton offspringof mothers who were randomized to fish oil (providing1 g/day of DHA) or olive oil during pregnancy asparticipants in: the RCT90, a single center trial enrollingnormal pregnancies in 1990, and FOTIP, a multicentertrial enrolling high-risk pregnancies during 1990–1996.We used definitions of ADHD and depression basedon ICD-10 codes and drug dispensary data, using informationon first prescription/hospital contact as a proxyfor ADHD and depression, respectively. We performedintention-to-treat analysis and report odds ratios (ORs)and 95% CI comparing the two intervention groups.Results: There were 17 and 35 cases of ADHD among offspringto participants in RCT90 and FOTIP, respectively;for depression corresponding numbers were 46 and 31. Inboth trials there was a reduced risk of ADHD in the fishoil groups, but this was not statistically significant[OR = 0.73(95% CI: 0.27;1.97), OR = 0.75(95% CI:0.38;1.50), respectively]. For depression, in the RCT90there was a non-significant reduced risk in the fish oilgroup, [OR = 0.71(95% CI: 0.38;1.33)]; whereas the ORin the FOTIP was approaching unity [OR = 1.09 (95%CI0.53;2.25)].Conclusions: We found no statistically significant effectsof fish oil supplementation during pregnancy on ADHDor depression in the offspring up to the age of 14–20.However, the results regarding ADHD point in the directionof a beneficial effect. The next step will be to poolthe two trials in a random effects model to test this in apopulation with better statistical power.

U2 - 10.1111/aogs.12087

DO - 10.1111/aogs.12087

M3 - Conference article

VL - 92

SP - 31

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - Suppl. 160

Y2 - 13 March 2013

ER -