Forty-Five-Year Mortality Rate as a Function of the Number and Type of Psychiatric Diagnoses Found in a Large Danish Birth Cohort
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Forty-Five-Year Mortality Rate as a Function of the Number and Type of Psychiatric Diagnoses Found in a Large Danish Birth Cohort. / Madarasz, Wendy; Manzardo, Ann; Mortensen, Erik Lykke; Penick, Elizabeth; Knop, Joachim; Sorensen, Holger; Becker, Ulrik; Nickel, Elizabeth; Gabrielli, William Jr.
In: Canadian Journal of Psychiatry, Vol. 57, No. 8, 2012, p. 505-511.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Forty-Five-Year Mortality Rate as a Function of the Number and Type of Psychiatric Diagnoses Found in a Large Danish Birth Cohort
AU - Madarasz, Wendy
AU - Manzardo, Ann
AU - Mortensen, Erik Lykke
AU - Penick, Elizabeth
AU - Knop, Joachim
AU - Sorensen, Holger
AU - Becker, Ulrik
AU - Nickel, Elizabeth
AU - Gabrielli, William Jr
PY - 2012
Y1 - 2012
N2 - Objective: Psychiatric comorbidities are common among psychiatric patients and typically associated with poorer clinical prognoses. Subjects of a large Danish birth cohort were used to study the relation between mortality and co-occurring psychiatric diagnoses. Method: We searched the Danish Central Psychiatric Research Registry for 8109 birth cohort members aged 45 years. Lifetime psychiatric diagnoses (International Classification of Diseases, Revision 10, group F codes, Mental and Behavioural Disorders, and one Z code) for identified subjects were organized into 14 mutually exclusive diagnostic categories. Mortality rates were examined as a function of number and type of co-occurring diagnoses. Results: Psychiatric outcomes for 1247 subjects were associated with 157 deaths. Early mortality risk in psychiatric patients correlated with the number of diagnostic categories (Wald ¿² = 25.0, df = 1, P <0.001). This global relation was true for anxiety and personality disorders, but not for schizophrenia and substance abuse, which had intrinsically high mortality rates with no comorbidities. Conclusions: Risk of early mortality among psychiatric patients appears to be a function of both the number and the type of psychiatric diagnoses.
AB - Objective: Psychiatric comorbidities are common among psychiatric patients and typically associated with poorer clinical prognoses. Subjects of a large Danish birth cohort were used to study the relation between mortality and co-occurring psychiatric diagnoses. Method: We searched the Danish Central Psychiatric Research Registry for 8109 birth cohort members aged 45 years. Lifetime psychiatric diagnoses (International Classification of Diseases, Revision 10, group F codes, Mental and Behavioural Disorders, and one Z code) for identified subjects were organized into 14 mutually exclusive diagnostic categories. Mortality rates were examined as a function of number and type of co-occurring diagnoses. Results: Psychiatric outcomes for 1247 subjects were associated with 157 deaths. Early mortality risk in psychiatric patients correlated with the number of diagnostic categories (Wald ¿² = 25.0, df = 1, P <0.001). This global relation was true for anxiety and personality disorders, but not for schizophrenia and substance abuse, which had intrinsically high mortality rates with no comorbidities. Conclusions: Risk of early mortality among psychiatric patients appears to be a function of both the number and the type of psychiatric diagnoses.
M3 - Journal article
C2 - 22854033
VL - 57
SP - 505
EP - 511
JO - Canadian Journal of Psychiatry
JF - Canadian Journal of Psychiatry
SN - 0706-7437
IS - 8
ER -
ID: 40995120