Frequency of cervical intraepithelial neoplasia treatment in a well-screened population
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Frequency of cervical intraepithelial neoplasia treatment in a well-screened population. / Barken, Sidsel Svennekjaer; Rebolj, Matejka; Andersen, Erik Søgaard; Lynge, Elsebeth.
In: International Journal of Cancer, Vol. 130, No. 10, 2012, p. 2438-44.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Frequency of cervical intraepithelial neoplasia treatment in a well-screened population
AU - Barken, Sidsel Svennekjaer
AU - Rebolj, Matejka
AU - Andersen, Erik Søgaard
AU - Lynge, Elsebeth
N1 - Copyright © 2011 UICC.
PY - 2012
Y1 - 2012
N2 - Treatment of cervical intraepithelial neoplasia (CIN) detectable at screening has helped reduce the incidence of cervical cancer, but has also led to overtreatment. The estimates of overtreatment have often focused on a particular grade of CIN or age group. The aim of this paper was to provide a nationwide population-based estimate of the frequency of CIN treatment per prevented cervical cancer case in a well-screened population. We retrieved the data from the Danish National Population, Patient, Health Insurance, Pathology, and Cancer Registers, and calculated annual age-standardized CIN treatment rates. We estimated the frequency of CIN treatment per prevented cervical cancer case by comparing the cumulative life-time risk of CIN treatment from 1996 onward, with the difference in the cumulative life-time risks of cervical cancer in the prescreening and the screening periods. Since 1996, more than 5,000 CIN treatments were undertaken annually in the population of about 2.2 million women aged 15-84 years, and at present 5.2 CIN treatments are undertaken per 1,000 women aged 20-49. About six women have undergone CIN treatment for each prevented cervical cancer. The frequency of CIN treatment increased after 2004 and at present almost eight women are treated per prevented cervical cancer case. Screening, though effective in reducing the incidence of cervical cancer, leads also to a considerable burden of CIN treatment. Future trends in CIN treatment should be closely monitored.
AB - Treatment of cervical intraepithelial neoplasia (CIN) detectable at screening has helped reduce the incidence of cervical cancer, but has also led to overtreatment. The estimates of overtreatment have often focused on a particular grade of CIN or age group. The aim of this paper was to provide a nationwide population-based estimate of the frequency of CIN treatment per prevented cervical cancer case in a well-screened population. We retrieved the data from the Danish National Population, Patient, Health Insurance, Pathology, and Cancer Registers, and calculated annual age-standardized CIN treatment rates. We estimated the frequency of CIN treatment per prevented cervical cancer case by comparing the cumulative life-time risk of CIN treatment from 1996 onward, with the difference in the cumulative life-time risks of cervical cancer in the prescreening and the screening periods. Since 1996, more than 5,000 CIN treatments were undertaken annually in the population of about 2.2 million women aged 15-84 years, and at present 5.2 CIN treatments are undertaken per 1,000 women aged 20-49. About six women have undergone CIN treatment for each prevented cervical cancer. The frequency of CIN treatment increased after 2004 and at present almost eight women are treated per prevented cervical cancer case. Screening, though effective in reducing the incidence of cervical cancer, leads also to a considerable burden of CIN treatment. Future trends in CIN treatment should be closely monitored.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Early Detection of Cancer
KW - Female
KW - Health Services Misuse
KW - Humans
KW - Incidence
KW - Mass Screening
KW - Middle Aged
KW - Risk Factors
KW - Uterine Cervical Neoplasms
U2 - 10.1002/ijc.26248
DO - 10.1002/ijc.26248
M3 - Journal article
C2 - 21702034
VL - 130
SP - 2438
EP - 2444
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 10
ER -
ID: 38295118