From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram : Synthesis and structure-activity relationship studies. / Eildal, Jonas Nii Nortey; Andersen, Jacob; Kristensen, Anders Skov; Jørgensen, Anne Marie; Bang-Andersen, Benny; Jørgensen, Morten; Strømgaard, Kristian.

In: Journal of Medicinal Chemistry, Vol. 51, No. 10, 2008, p. 3045-3048.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Eildal, JNN, Andersen, J, Kristensen, AS, Jørgensen, AM, Bang-Andersen, B, Jørgensen, M & Strømgaard, K 2008, 'From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies', Journal of Medicinal Chemistry, vol. 51, no. 10, pp. 3045-3048. https://doi.org/10.1021/jm701602g

APA

Eildal, J. N. N., Andersen, J., Kristensen, A. S., Jørgensen, A. M., Bang-Andersen, B., Jørgensen, M., & Strømgaard, K. (2008). From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies. Journal of Medicinal Chemistry, 51(10), 3045-3048. https://doi.org/10.1021/jm701602g

Vancouver

Eildal JNN, Andersen J, Kristensen AS, Jørgensen AM, Bang-Andersen B, Jørgensen M et al. From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies. Journal of Medicinal Chemistry. 2008;51(10):3045-3048. https://doi.org/10.1021/jm701602g

Author

Eildal, Jonas Nii Nortey ; Andersen, Jacob ; Kristensen, Anders Skov ; Jørgensen, Anne Marie ; Bang-Andersen, Benny ; Jørgensen, Morten ; Strømgaard, Kristian. / From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram : Synthesis and structure-activity relationship studies. In: Journal of Medicinal Chemistry. 2008 ; Vol. 51, No. 10. pp. 3045-3048.

Bibtex

@article{25350250a9a211ddb5e9000ea68e967b,
title = "From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies",
abstract = "Citalopram and talopram are structurally closely related, but they have very distinct pharmacological profiles as selective inhibitors of the serotonin and norepinephrine transporters, respectively. A systematic structure-activity relationship study was performed, in which each of the four positions distinguishing the two compounds were varied. The inhibitory potencies of the resulting 16 compounds were tested at both serotonin and norepinephrine transporters. This showed that particularly two of the four positions are determinants for the biological activity.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Eildal, {Jonas Nii Nortey} and Jacob Andersen and Kristensen, {Anders Skov} and J{\o}rgensen, {Anne Marie} and Benny Bang-Andersen and Morten J{\o}rgensen and Kristian Str{\o}mgaard",
note = "Keywords: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Humans; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Rats; Recombinant Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship; Synaptosomes",
year = "2008",
doi = "10.1021/jm701602g",
language = "English",
volume = "51",
pages = "3045--3048",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "10",

}

RIS

TY - JOUR

T1 - From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram

T2 - Synthesis and structure-activity relationship studies

AU - Eildal, Jonas Nii Nortey

AU - Andersen, Jacob

AU - Kristensen, Anders Skov

AU - Jørgensen, Anne Marie

AU - Bang-Andersen, Benny

AU - Jørgensen, Morten

AU - Strømgaard, Kristian

N1 - Keywords: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Humans; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Rats; Recombinant Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship; Synaptosomes

PY - 2008

Y1 - 2008

N2 - Citalopram and talopram are structurally closely related, but they have very distinct pharmacological profiles as selective inhibitors of the serotonin and norepinephrine transporters, respectively. A systematic structure-activity relationship study was performed, in which each of the four positions distinguishing the two compounds were varied. The inhibitory potencies of the resulting 16 compounds were tested at both serotonin and norepinephrine transporters. This showed that particularly two of the four positions are determinants for the biological activity.

AB - Citalopram and talopram are structurally closely related, but they have very distinct pharmacological profiles as selective inhibitors of the serotonin and norepinephrine transporters, respectively. A systematic structure-activity relationship study was performed, in which each of the four positions distinguishing the two compounds were varied. The inhibitory potencies of the resulting 16 compounds were tested at both serotonin and norepinephrine transporters. This showed that particularly two of the four positions are determinants for the biological activity.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/jm701602g

DO - 10.1021/jm701602g

M3 - Journal article

C2 - 18429609

VL - 51

SP - 3045

EP - 3048

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 10

ER -

ID: 8378305