Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology

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Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. / Schnurr, Theresia Maria; Gjesing, Anette Marianne Prior; Sandholt, Camilla Helene; Jonsson, Anna Elisabet; Mahendran, Yuvaraj; Have, Christian Theil; Ekstrøm, Claus Thorn; Bjerregaard, Anne-Louise; Brage, Søren; Witte, Daniel; Jørgensen, Marit Eika; Aadahl, Mette; Thuesen, Betina Heinsbæk; Linneberg, Allan René; Eiberg, Hans Rudolf Lytchoff; Pedersen, Oluf Borbye; Grarup, Niels; Oskari Kilpeläinen, Tuomas; Hansen, Torben.

In: P L o S One, Vol. 11, No. 11, e0166738, 15.11.2016.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Schnurr, TM, Gjesing, AMP, Sandholt, CH, Jonsson, AE, Mahendran, Y, Have, CT, Ekstrøm, CT, Bjerregaard, A-L, Brage, S, Witte, D, Jørgensen, ME, Aadahl, M, Thuesen, BH, Linneberg, AR, Eiberg, HRL, Pedersen, OB, Grarup, N, Oskari Kilpeläinen, T & Hansen, T 2016, 'Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology' P L o S One, vol. 11, no. 11, e0166738.

APA

Schnurr, T. M., Gjesing, A. M. P., Sandholt, C. H., Jonsson, A. E., Mahendran, Y., Have, C. T., ... Hansen, T. (2016). Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. P L o S One, 11(11), [e0166738].

Vancouver

Schnurr TM, Gjesing AMP, Sandholt CH, Jonsson AE, Mahendran Y, Have CT et al. Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. P L o S One. 2016 Nov 15;11(11). e0166738.

Author

Schnurr, Theresia Maria ; Gjesing, Anette Marianne Prior ; Sandholt, Camilla Helene ; Jonsson, Anna Elisabet ; Mahendran, Yuvaraj ; Have, Christian Theil ; Ekstrøm, Claus Thorn ; Bjerregaard, Anne-Louise ; Brage, Søren ; Witte, Daniel ; Jørgensen, Marit Eika ; Aadahl, Mette ; Thuesen, Betina Heinsbæk ; Linneberg, Allan René ; Eiberg, Hans Rudolf Lytchoff ; Pedersen, Oluf Borbye ; Grarup, Niels ; Oskari Kilpeläinen, Tuomas ; Hansen, Torben. / Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. In: P L o S One. 2016 ; Vol. 11, No. 11.

Bibtex

@article{6b281794eef9431bbfebfe6bf0b85345,
title = "Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology",
abstract = "Objectives: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat{\%}) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat{\%} and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat{\%} increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF. Methods: Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat{\%} GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat{\%}. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition. Results: We found a significant negative genetic correlation between VO2max and body fat{\%} (ρG = -0.72 (SE ±0.13)). The body fat{\%} GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat{\%}-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat{\%}. The fat{\%} increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM. Conclusions: Our findings suggest a shared genetic etiology between whole body fat{\%} and CRF.",
author = "Schnurr, {Theresia Maria} and Gjesing, {Anette Marianne Prior} and Sandholt, {Camilla Helene} and Jonsson, {Anna Elisabet} and Yuvaraj Mahendran and Have, {Christian Theil} and Ekstr{\o}m, {Claus Thorn} and Anne-Louise Bjerregaard and S{\o}ren Brage and Daniel Witte and J{\o}rgensen, {Marit Eika} and Mette Aadahl and Thuesen, {Betina Heinsb{\ae}k} and Linneberg, {Allan Ren{\'e}} and Eiberg, {Hans Rudolf Lytchoff} and Pedersen, {Oluf Borbye} and Niels Grarup and {Oskari Kilpel{\"a}inen}, Tuomas and Torben Hansen",
year = "2016",
month = "11",
day = "15",
language = "English",
volume = "11",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology

AU - Schnurr, Theresia Maria

AU - Gjesing, Anette Marianne Prior

AU - Sandholt, Camilla Helene

AU - Jonsson, Anna Elisabet

AU - Mahendran, Yuvaraj

AU - Have, Christian Theil

AU - Ekstrøm, Claus Thorn

AU - Bjerregaard, Anne-Louise

AU - Brage, Søren

AU - Witte, Daniel

AU - Jørgensen, Marit Eika

AU - Aadahl, Mette

AU - Thuesen, Betina Heinsbæk

AU - Linneberg, Allan René

AU - Eiberg, Hans Rudolf Lytchoff

AU - Pedersen, Oluf Borbye

AU - Grarup, Niels

AU - Oskari Kilpeläinen, Tuomas

AU - Hansen, Torben

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Objectives: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF. Methods: Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat% GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat%. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition. Results: We found a significant negative genetic correlation between VO2max and body fat% (ρG = -0.72 (SE ±0.13)). The body fat% GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat%-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat%. The fat% increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM. Conclusions: Our findings suggest a shared genetic etiology between whole body fat% and CRF.

AB - Objectives: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF. Methods: Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat% GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat%. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition. Results: We found a significant negative genetic correlation between VO2max and body fat% (ρG = -0.72 (SE ±0.13)). The body fat% GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat%-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat%. The fat% increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM. Conclusions: Our findings suggest a shared genetic etiology between whole body fat% and CRF.

M3 - Journal article

VL - 11

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 11

M1 - e0166738

ER -

ID: 169359873