How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?

Research output: Contribution to journal › Journal article › Research › peer-review

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How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK? / Straatmann, Viviane S.; Lai, Eric; Law, Catherine; Whitehead, Margaret; Strandberg-Larsen, Katrine; Taylor-Robinson, David.

In: Journal of Epidemiology and Community Health, Vol. 74, No. 11, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Straatmann, VS, Lai, E, Law, C, Whitehead, M, Strandberg-Larsen, K & Taylor-Robinson, D 2020, 'How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?', Journal of Epidemiology and Community Health, vol. 74, no. 11. https://doi.org/10.1136/jech-2020-213817

APA

Straatmann, V. S., Lai, E., Law, C., Whitehead, M., Strandberg-Larsen, K., & Taylor-Robinson, D. (2020). How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK? Journal of Epidemiology and Community Health, 74(11). https://doi.org/10.1136/jech-2020-213817

Vancouver

Straatmann VS, Lai E, Law C, Whitehead M, Strandberg-Larsen K, Taylor-Robinson D. How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK? Journal of Epidemiology and Community Health. 2020;74(11). https://doi.org/10.1136/jech-2020-213817

Author

Straatmann, Viviane S. ; Lai, Eric ; Law, Catherine ; Whitehead, Margaret ; Strandberg-Larsen, Katrine ; Taylor-Robinson, David. / How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?. In: Journal of Epidemiology and Community Health. 2020 ; Vol. 74, No. 11.

Bibtex

@article{f3db0c2c7fbd423f90fdc4cb2a6e2d63,
title = "How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?",
abstract = "Background: Both adverse childhood experiences (ACEs) and adverse childhood socioeconomic conditions (SECs) in early life are associated with poor outcomes across the life course. However, the complex interrelationships between childhood SECs and ACEs are unclear, as are the consequences for health outcomes beyond childhood. We therefore assessed the extent to which early-life ACEs mediate the relationship between SECs and socioemotional behavioural problems, cognitive disability and overweight/obesity in adolescence. Methods: We used longitudinal data from the UK Millennium Cohort Study (MSC). Outcomes assessed at age 14 were socioemotional behavioural problems, cognitive disability and overweight/obesity. SECs at birth were measured by maternal education. Potentially mediating ACEs measured up to 5 years were verbal and physical maltreatment, parental drug use, domestic violence, parental divorce, maternal mental illness and high frequency of parental alcohol use. We used counterfactual mediation analysis to assess the extent to which ACEs mediate the association between SECs at birth and behavioural, cognitive and physical outcomes at age 14, estimating total (TE), natural direct and indirect effects, and mediated proportions. Results: Children with disadvantaged SECs were more likely to have socioemotional behavioural problems (relative risk (RR) 3.85, 95% CI 2.48 to 5.97), cognitive disability (RR 3.87, 95% CI 2.33 to 6.43) and overweight/obesity (RR 1.61, 95% CI 1.32 to 1.95), compared to those with more advantaged SECs. Overall, 18% of the TE of SECs on socioemotional behavioural problems was mediated through all ACEs investigated. For cognitive disability and overweight/obese, the proportions mediated were 13% and 19%, respectively. Conclusion: ACEs measured up to age 5 years in the MCS explained about one-sixth of inequalities in adolescents behavioural, cognitive and physical outcomes. ",
keywords = "child health, cohort studies, Health inequalities, public health",
author = "Straatmann, {Viviane S.} and Eric Lai and Catherine Law and Margaret Whitehead and Katrine Strandberg-Larsen and David Taylor-Robinson",
year = "2020",
doi = "10.1136/jech-2020-213817",
language = "English",
volume = "74",
journal = "Journal of Epidemiology & Community Health",
issn = "0143-005X",
publisher = "B M J Group",
number = "11",

}

RIS

TY - JOUR

T1 - How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?

AU - Straatmann, Viviane S.

AU - Lai, Eric

AU - Law, Catherine

AU - Whitehead, Margaret

AU - Strandberg-Larsen, Katrine

AU - Taylor-Robinson, David

PY - 2020

Y1 - 2020

N2 - Background: Both adverse childhood experiences (ACEs) and adverse childhood socioeconomic conditions (SECs) in early life are associated with poor outcomes across the life course. However, the complex interrelationships between childhood SECs and ACEs are unclear, as are the consequences for health outcomes beyond childhood. We therefore assessed the extent to which early-life ACEs mediate the relationship between SECs and socioemotional behavioural problems, cognitive disability and overweight/obesity in adolescence. Methods: We used longitudinal data from the UK Millennium Cohort Study (MSC). Outcomes assessed at age 14 were socioemotional behavioural problems, cognitive disability and overweight/obesity. SECs at birth were measured by maternal education. Potentially mediating ACEs measured up to 5 years were verbal and physical maltreatment, parental drug use, domestic violence, parental divorce, maternal mental illness and high frequency of parental alcohol use. We used counterfactual mediation analysis to assess the extent to which ACEs mediate the association between SECs at birth and behavioural, cognitive and physical outcomes at age 14, estimating total (TE), natural direct and indirect effects, and mediated proportions. Results: Children with disadvantaged SECs were more likely to have socioemotional behavioural problems (relative risk (RR) 3.85, 95% CI 2.48 to 5.97), cognitive disability (RR 3.87, 95% CI 2.33 to 6.43) and overweight/obesity (RR 1.61, 95% CI 1.32 to 1.95), compared to those with more advantaged SECs. Overall, 18% of the TE of SECs on socioemotional behavioural problems was mediated through all ACEs investigated. For cognitive disability and overweight/obese, the proportions mediated were 13% and 19%, respectively. Conclusion: ACEs measured up to age 5 years in the MCS explained about one-sixth of inequalities in adolescents behavioural, cognitive and physical outcomes.

AB - Background: Both adverse childhood experiences (ACEs) and adverse childhood socioeconomic conditions (SECs) in early life are associated with poor outcomes across the life course. However, the complex interrelationships between childhood SECs and ACEs are unclear, as are the consequences for health outcomes beyond childhood. We therefore assessed the extent to which early-life ACEs mediate the relationship between SECs and socioemotional behavioural problems, cognitive disability and overweight/obesity in adolescence. Methods: We used longitudinal data from the UK Millennium Cohort Study (MSC). Outcomes assessed at age 14 were socioemotional behavioural problems, cognitive disability and overweight/obesity. SECs at birth were measured by maternal education. Potentially mediating ACEs measured up to 5 years were verbal and physical maltreatment, parental drug use, domestic violence, parental divorce, maternal mental illness and high frequency of parental alcohol use. We used counterfactual mediation analysis to assess the extent to which ACEs mediate the association between SECs at birth and behavioural, cognitive and physical outcomes at age 14, estimating total (TE), natural direct and indirect effects, and mediated proportions. Results: Children with disadvantaged SECs were more likely to have socioemotional behavioural problems (relative risk (RR) 3.85, 95% CI 2.48 to 5.97), cognitive disability (RR 3.87, 95% CI 2.33 to 6.43) and overweight/obesity (RR 1.61, 95% CI 1.32 to 1.95), compared to those with more advantaged SECs. Overall, 18% of the TE of SECs on socioemotional behavioural problems was mediated through all ACEs investigated. For cognitive disability and overweight/obese, the proportions mediated were 13% and 19%, respectively. Conclusion: ACEs measured up to age 5 years in the MCS explained about one-sixth of inequalities in adolescents behavioural, cognitive and physical outcomes.

KW - child health

KW - cohort studies

KW - Health inequalities

KW - public health

U2 - 10.1136/jech-2020-213817

DO - 10.1136/jech-2020-213817

M3 - Journal article

C2 - 32855260

AN - SCOPUS:85091772171

VL - 74

JO - Journal of Epidemiology & Community Health

JF - Journal of Epidemiology & Community Health

SN - 0143-005X

IS - 11

ER -

ID: 250597040