Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration. / Jørgensen, Anna Cecilia; Torstenson, Anette Seo.

In: Pharmaceutical Development and Technology, Vol. 13, No. 3, 2008, p. 187-95.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, AC & Torstenson, AS 2008, 'Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration', Pharmaceutical Development and Technology, vol. 13, no. 3, pp. 187-95. https://doi.org/10.1080/10837450801949384

APA

Jørgensen, A. C., & Torstenson, A. S. (2008). Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration. Pharmaceutical Development and Technology, 13(3), 187-95. https://doi.org/10.1080/10837450801949384

Vancouver

Jørgensen AC, Torstenson AS. Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration. Pharmaceutical Development and Technology. 2008;13(3):187-95. https://doi.org/10.1080/10837450801949384

Author

Jørgensen, Anna Cecilia ; Torstenson, Anette Seo. / Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration. In: Pharmaceutical Development and Technology. 2008 ; Vol. 13, No. 3. pp. 187-95.

Bibtex

@article{141ce490cb4611dd9473000ea68e967b,
title = "Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration",
abstract = "The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "J{\o}rgensen, {Anna Cecilia} and Torstenson, {Anette Seo}",
note = "Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction",
year = "2008",
doi = "10.1080/10837450801949384",
language = "English",
volume = "13",
pages = "187--95",
journal = "Pharmaceutical Development and Technology",
issn = "1083-7450",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

AU - Jørgensen, Anna Cecilia

AU - Torstenson, Anette Seo

N1 - Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction

PY - 2008

Y1 - 2008

N2 - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

AB - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1080/10837450801949384

DO - 10.1080/10837450801949384

M3 - Journal article

C2 - 18484487

VL - 13

SP - 187

EP - 195

JO - Pharmaceutical Development and Technology

JF - Pharmaceutical Development and Technology

SN - 1083-7450

IS - 3

ER -

ID: 9171914