Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau
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- Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau
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Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.
Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.
Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline more for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect.
Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.
|Journal||Journal of Tropical Pediatrics|
|Number of pages||11|
|Publication status||Published - 2019|
A correction has been published:
Journal of Tropical Pediatrics, fmz009, https://doi.org/10.1093/tropej/fmz009
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