Incidence of cervical cancer after several negative smear results by age 50: prospective observational study

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Incidence of cervical cancer after several negative smear results by age 50: prospective observational study. / Rebolj, Matejka; van Ballegooijen, Marjolein; Lynge, Elsebeth; Looman, Caspar; Essink-Bot, Marie-Louise; Boer, Rob; Habbema, Dik.

In: BMJ. British Medical Journal (International Ed.), Vol. 338, 2009, p. b1354.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rebolj, M, van Ballegooijen, M, Lynge, E, Looman, C, Essink-Bot, M-L, Boer, R & Habbema, D 2009, 'Incidence of cervical cancer after several negative smear results by age 50: prospective observational study', BMJ. British Medical Journal (International Ed.), vol. 338, pp. b1354.

APA

Rebolj, M., van Ballegooijen, M., Lynge, E., Looman, C., Essink-Bot, M-L., Boer, R., & Habbema, D. (2009). Incidence of cervical cancer after several negative smear results by age 50: prospective observational study. BMJ. British Medical Journal (International Ed.), 338, b1354.

Vancouver

Rebolj M, van Ballegooijen M, Lynge E, Looman C, Essink-Bot M-L, Boer R et al. Incidence of cervical cancer after several negative smear results by age 50: prospective observational study. BMJ. British Medical Journal (International Ed.). 2009;338:b1354.

Author

Rebolj, Matejka ; van Ballegooijen, Marjolein ; Lynge, Elsebeth ; Looman, Caspar ; Essink-Bot, Marie-Louise ; Boer, Rob ; Habbema, Dik. / Incidence of cervical cancer after several negative smear results by age 50: prospective observational study. In: BMJ. British Medical Journal (International Ed.). 2009 ; Vol. 338. pp. b1354.

Bibtex

@article{d6214b60873b11de8bc9000ea68e967b,
title = "Incidence of cervical cancer after several negative smear results by age 50: prospective observational study",
abstract = "OBJECTIVE: To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN: Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry of histopathology and cytopathology (PALGA). SETTING: Netherlands, national data. Population 218,847 women aged 45-54 and 445,382 aged 30-44 at the time of the third negative smear test. MAIN OUTCOME MEASURES: 10 year cumulative incidence of interval cervical cancer. RESULTS: 105 women developed cervical cancer within 2 595,964 woman years at risk after the third negative result at age 30-44 and 42 within 1,278,532 woman years at risk after age 45-54. During follow-up, both age groups had similar levels of screening. After 10 years of follow-up, the cumulative incidence rate of cervical cancer was similar: 41/100,000 (95% confidence interval 33 to 51) in the younger group and 36/100,000 (24 to 52) in the older group (P=0.48). The cumulative incidence rate of cervical intraepithelial neoplasia grade I+ was twice as high in the younger than in the older group (P<0.001). CONCLUSIONS: The risk for cervical cancer after several negative smear results by age 50 is similar to the risk at younger ages. Even after several negative smear results, age is not a good discriminative factor for early cessation of cervical cancer screening.",
author = "Matejka Rebolj and {van Ballegooijen}, Marjolein and Elsebeth Lynge and Caspar Looman and Marie-Louise Essink-Bot and Rob Boer and Dik Habbema",
note = "Keywords: Adult; Age Distribution; Aged; Female; Humans; Incidence; Mass Screening; Middle Aged; Netherlands; Prospective Studies; Risk Factors; Uterine Cervical Neoplasms; Vaginal Smears",
year = "2009",
language = "English",
volume = "338",
pages = "b1354",
journal = "B M J",
issn = "0959-8146",
publisher = "BMJ Publishing Group",

}

RIS

TY - JOUR

T1 - Incidence of cervical cancer after several negative smear results by age 50: prospective observational study

AU - Rebolj, Matejka

AU - van Ballegooijen, Marjolein

AU - Lynge, Elsebeth

AU - Looman, Caspar

AU - Essink-Bot, Marie-Louise

AU - Boer, Rob

AU - Habbema, Dik

N1 - Keywords: Adult; Age Distribution; Aged; Female; Humans; Incidence; Mass Screening; Middle Aged; Netherlands; Prospective Studies; Risk Factors; Uterine Cervical Neoplasms; Vaginal Smears

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN: Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry of histopathology and cytopathology (PALGA). SETTING: Netherlands, national data. Population 218,847 women aged 45-54 and 445,382 aged 30-44 at the time of the third negative smear test. MAIN OUTCOME MEASURES: 10 year cumulative incidence of interval cervical cancer. RESULTS: 105 women developed cervical cancer within 2 595,964 woman years at risk after the third negative result at age 30-44 and 42 within 1,278,532 woman years at risk after age 45-54. During follow-up, both age groups had similar levels of screening. After 10 years of follow-up, the cumulative incidence rate of cervical cancer was similar: 41/100,000 (95% confidence interval 33 to 51) in the younger group and 36/100,000 (24 to 52) in the older group (P=0.48). The cumulative incidence rate of cervical intraepithelial neoplasia grade I+ was twice as high in the younger than in the older group (P<0.001). CONCLUSIONS: The risk for cervical cancer after several negative smear results by age 50 is similar to the risk at younger ages. Even after several negative smear results, age is not a good discriminative factor for early cessation of cervical cancer screening.

AB - OBJECTIVE: To determine the incidence of cervical cancer after several negative cervical smear tests at different ages. DESIGN: Prospective observational study of incidence of cervical cancer after the third consecutive negative result based on individual level data in a national registry of histopathology and cytopathology (PALGA). SETTING: Netherlands, national data. Population 218,847 women aged 45-54 and 445,382 aged 30-44 at the time of the third negative smear test. MAIN OUTCOME MEASURES: 10 year cumulative incidence of interval cervical cancer. RESULTS: 105 women developed cervical cancer within 2 595,964 woman years at risk after the third negative result at age 30-44 and 42 within 1,278,532 woman years at risk after age 45-54. During follow-up, both age groups had similar levels of screening. After 10 years of follow-up, the cumulative incidence rate of cervical cancer was similar: 41/100,000 (95% confidence interval 33 to 51) in the younger group and 36/100,000 (24 to 52) in the older group (P=0.48). The cumulative incidence rate of cervical intraepithelial neoplasia grade I+ was twice as high in the younger than in the older group (P<0.001). CONCLUSIONS: The risk for cervical cancer after several negative smear results by age 50 is similar to the risk at younger ages. Even after several negative smear results, age is not a good discriminative factor for early cessation of cervical cancer screening.

M3 - Journal article

C2 - 19395420

VL - 338

SP - b1354

JO - B M J

JF - B M J

SN - 0959-8146

ER -

ID: 13717848