Ketone body infusion abrogates growth hormone-induced lipolysis and insulin resistance
Research output: Contribution to journal › Journal article › peer-review
Background: Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain.
Objective: We tested the hypothesis that administration of the ketone body β-hydroxybutyrate (βOHB) acutely increases insulin sensitivity via feedback suppression of circulating free fatty acid (FFA) levels.
Methods: In a randomized, single-blinded crossover design, 8 healthy men were studied twice with a growth hormone (GH) infusion to induce lipolysis in combination with infusion of either βOHB or saline. Each study day comprised a basal period and a hyperinsulinemic-euglycemic clamp combined with a glucose tracer and adipose tissue and skeletal muscle biopsies.
Results: βOHB administration profoundly suppressed FFA levels concomitantly with a significant increase in glucose disposal and energy expenditure. This was accompanied by a many-fold increase in skeletal muscle content of both βOHB and its derivative acetoacetate.
Conclusion: Our data unravel an insulin-sensitizing effect of βOHB, which we suggest is mediated by concomitant suppression of lipolysis.
|Journal||Journal of Clinical Endocrinology and Metabolism|
|Number of pages||12|
|Publication status||Published - 2023|
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- Faculty of Science - Ketone bodies, β-hydroxybutyrate, Insulin sensitivity, Glucose metabolism, Growth hormone, Free fatty acids