Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes

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Lactation Duration and Long-Term Thyroid Function : A Study among Women with Gestational Diabetes. / Panuganti, Pranati L; Hinkle, Stefanie N; Rawal, Shristi; Grunnet, Louise G; Lin, Yuan; Liu, Aiyi; Thuesen, Anne C B; Ley, Sylvia H; Olesen, Sjurdur F; Zhang, Cuilin.

In: Nutrients, Vol. 10, No. 7, 938, 21.07.2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Panuganti, PL, Hinkle, SN, Rawal, S, Grunnet, LG, Lin, Y, Liu, A, Thuesen, ACB, Ley, SH, Olesen, SF & Zhang, C 2018, 'Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes', Nutrients, vol. 10, no. 7, 938. https://doi.org/10.3390/nu10070938

APA

Panuganti, P. L., Hinkle, S. N., Rawal, S., Grunnet, L. G., Lin, Y., Liu, A., ... Zhang, C. (2018). Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes. Nutrients, 10(7), [ 938]. https://doi.org/10.3390/nu10070938

Vancouver

Panuganti PL, Hinkle SN, Rawal S, Grunnet LG, Lin Y, Liu A et al. Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes. Nutrients. 2018 Jul 21;10(7). 938. https://doi.org/10.3390/nu10070938

Author

Panuganti, Pranati L ; Hinkle, Stefanie N ; Rawal, Shristi ; Grunnet, Louise G ; Lin, Yuan ; Liu, Aiyi ; Thuesen, Anne C B ; Ley, Sylvia H ; Olesen, Sjurdur F ; Zhang, Cuilin. / Lactation Duration and Long-Term Thyroid Function : A Study among Women with Gestational Diabetes. In: Nutrients. 2018 ; Vol. 10, No. 7.

Bibtex

@article{5852aec74c0c41579c59e084b28c083e,
title = "Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes",
abstract = "Lactation is associated with reduced postpartum weight retention and a lower risk of several cardiometabolic disorders in population-based studies. We examined the association between lactation and long-term thyroid function among women with history of gestational diabetes mellitus (GDM), a high-risk population for subsequent metabolic complications. The study included 550 women who developed GDM in the Danish National Birth Cohort (1996⁻2002) and followed-up in the Diabetes & Women's Health Study (2012⁻2014). We assessed adjusted associations between cumulative lactation duration and concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) measured at follow-up. Women with longer cumulative lactation duration tended to have higher fT3 levels (adjusted β and 95{\%} confidence interval (CI) for ≥12 months vs. none: 0.19 (0.03⁻0.36); p-trend = 0.05). When restricted to women with a single lifetime pregnancy to control for parity (n = 70), women who lactated for >6 months (vs. none) had higher fT3 levels (0.46 pmol/L (0.12⁻0.80); p-trend = 0.02) and a higher fT3:fT4 ratio (0.61 (0.17⁻1.05); p-trend = 0.007). Our findings suggested that a longer duration of lactation may be related to greater serum fT3 levels and fT3:fT4 ratio 9⁻16 years postpartum among Danish women with a history of GDM. The association was particularly pronounced among women who only had one lifetime pregnancy.",
keywords = "Adult, Antibodies/blood, Biomarkers, Cohort Studies, Diabetes, Gestational, Female, Humans, Hyperthyroidism, Hypothyroidism/blood, Iodide Peroxidase/immunology, Lactation/physiology, Pregnancy, Risk Factors, Thyroid Gland/physiology, Thyroxine/blood, Time Factors, Women's Health",
author = "Panuganti, {Pranati L} and Hinkle, {Stefanie N} and Shristi Rawal and Grunnet, {Louise G} and Yuan Lin and Aiyi Liu and Thuesen, {Anne C B} and Ley, {Sylvia H} and Olesen, {Sjurdur F} and Cuilin Zhang",
year = "2018",
month = "7",
day = "21",
doi = "10.3390/nu10070938",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "7",

}

RIS

TY - JOUR

T1 - Lactation Duration and Long-Term Thyroid Function

T2 - A Study among Women with Gestational Diabetes

AU - Panuganti, Pranati L

AU - Hinkle, Stefanie N

AU - Rawal, Shristi

AU - Grunnet, Louise G

AU - Lin, Yuan

AU - Liu, Aiyi

AU - Thuesen, Anne C B

AU - Ley, Sylvia H

AU - Olesen, Sjurdur F

AU - Zhang, Cuilin

PY - 2018/7/21

Y1 - 2018/7/21

N2 - Lactation is associated with reduced postpartum weight retention and a lower risk of several cardiometabolic disorders in population-based studies. We examined the association between lactation and long-term thyroid function among women with history of gestational diabetes mellitus (GDM), a high-risk population for subsequent metabolic complications. The study included 550 women who developed GDM in the Danish National Birth Cohort (1996⁻2002) and followed-up in the Diabetes & Women's Health Study (2012⁻2014). We assessed adjusted associations between cumulative lactation duration and concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) measured at follow-up. Women with longer cumulative lactation duration tended to have higher fT3 levels (adjusted β and 95% confidence interval (CI) for ≥12 months vs. none: 0.19 (0.03⁻0.36); p-trend = 0.05). When restricted to women with a single lifetime pregnancy to control for parity (n = 70), women who lactated for >6 months (vs. none) had higher fT3 levels (0.46 pmol/L (0.12⁻0.80); p-trend = 0.02) and a higher fT3:fT4 ratio (0.61 (0.17⁻1.05); p-trend = 0.007). Our findings suggested that a longer duration of lactation may be related to greater serum fT3 levels and fT3:fT4 ratio 9⁻16 years postpartum among Danish women with a history of GDM. The association was particularly pronounced among women who only had one lifetime pregnancy.

AB - Lactation is associated with reduced postpartum weight retention and a lower risk of several cardiometabolic disorders in population-based studies. We examined the association between lactation and long-term thyroid function among women with history of gestational diabetes mellitus (GDM), a high-risk population for subsequent metabolic complications. The study included 550 women who developed GDM in the Danish National Birth Cohort (1996⁻2002) and followed-up in the Diabetes & Women's Health Study (2012⁻2014). We assessed adjusted associations between cumulative lactation duration and concentrations of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) measured at follow-up. Women with longer cumulative lactation duration tended to have higher fT3 levels (adjusted β and 95% confidence interval (CI) for ≥12 months vs. none: 0.19 (0.03⁻0.36); p-trend = 0.05). When restricted to women with a single lifetime pregnancy to control for parity (n = 70), women who lactated for >6 months (vs. none) had higher fT3 levels (0.46 pmol/L (0.12⁻0.80); p-trend = 0.02) and a higher fT3:fT4 ratio (0.61 (0.17⁻1.05); p-trend = 0.007). Our findings suggested that a longer duration of lactation may be related to greater serum fT3 levels and fT3:fT4 ratio 9⁻16 years postpartum among Danish women with a history of GDM. The association was particularly pronounced among women who only had one lifetime pregnancy.

KW - Adult

KW - Antibodies/blood

KW - Biomarkers

KW - Cohort Studies

KW - Diabetes, Gestational

KW - Female

KW - Humans

KW - Hyperthyroidism

KW - Hypothyroidism/blood

KW - Iodide Peroxidase/immunology

KW - Lactation/physiology

KW - Pregnancy

KW - Risk Factors

KW - Thyroid Gland/physiology

KW - Thyroxine/blood

KW - Time Factors

KW - Women's Health

U2 - 10.3390/nu10070938

DO - 10.3390/nu10070938

M3 - Journal article

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 7

M1 - 938

ER -

ID: 210923708