Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

Research output: Contribution to journalJournal articleResearchpeer-review

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Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. / Andersen, Zorana J.; Stafoggia, Massimo; Weinmayr, Gudrun; Pedersen, Marie; Galassi, Claudia; Jørgensen, Jeanette T.; Oudin, Anna; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Marit Aasvang, Gunn; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L; Östenson, Claes-Göran; Fratiglioni, Laura; Eriksen, Kirsten T.; Tjønneland, Anne; Peeters, Petra H; Bueno-de-Mesquita, Bas; Plusquin, Michelle; Key, Timothy J; Jaensch, Andrea; Nagel, Gabriele; Lang, Alois; Wang, Meng; Tsai, Ming-Yi; Fournier, Agnes; Boutron-Ruault, Marie-Christine; Baglietto, Laura; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Migliore, Enrica; Tamayo-Uria, Ibon; Amiano, Pilar; Dorronsoro, Miren; Vermeulen, Roel; Sokhi, Ranjeet; Keuken, Menno; de Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Cesaroni, Giulia; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.

In: Environmental Health Perspectives, Vol. 125, No. 10, 107005, 13.10.2017, p. 1-14.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Andersen, ZJ, Stafoggia, M, Weinmayr, G, Pedersen, M, Galassi, C, Jørgensen, JT, Oudin, A, Forsberg, B, Olsson, D, Oftedal, B, Marit Aasvang, G, Aamodt, G, Pyko, A, Pershagen, G, Korek, M, De Faire, U, Pedersen, NL, Östenson, C-G, Fratiglioni, L, Eriksen, KT, Tjønneland, A, Peeters, PH, Bueno-de-Mesquita, B, Plusquin, M, Key, TJ, Jaensch, A, Nagel, G, Lang, A, Wang, M, Tsai, M-Y, Fournier, A, Boutron-Ruault, M-C, Baglietto, L, Grioni, S, Marcon, A, Krogh, V, Ricceri, F, Sacerdote, C, Migliore, E, Tamayo-Uria, I, Amiano, P, Dorronsoro, M, Vermeulen, R, Sokhi, R, Keuken, M, de Hoogh, K, Beelen, R, Vineis, P, Cesaroni, G, Brunekreef, B, Hoek, G & Raaschou-Nielsen, O 2017, 'Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project', Environmental Health Perspectives, vol. 125, no. 10, 107005, pp. 1-14. https://doi.org/10.1289/EHP1742

APA

Andersen, Z. J., Stafoggia, M., Weinmayr, G., Pedersen, M., Galassi, C., Jørgensen, J. T., ... Raaschou-Nielsen, O. (2017). Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. Environmental Health Perspectives, 125(10), 1-14. [107005]. https://doi.org/10.1289/EHP1742

Vancouver

Andersen ZJ, Stafoggia M, Weinmayr G, Pedersen M, Galassi C, Jørgensen JT et al. Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. Environmental Health Perspectives. 2017 Oct 13;125(10):1-14. 107005. https://doi.org/10.1289/EHP1742

Author

Andersen, Zorana J. ; Stafoggia, Massimo ; Weinmayr, Gudrun ; Pedersen, Marie ; Galassi, Claudia ; Jørgensen, Jeanette T. ; Oudin, Anna ; Forsberg, Bertil ; Olsson, David ; Oftedal, Bente ; Marit Aasvang, Gunn ; Aamodt, Geir ; Pyko, Andrei ; Pershagen, Göran ; Korek, Michal ; De Faire, Ulf ; Pedersen, Nancy L ; Östenson, Claes-Göran ; Fratiglioni, Laura ; Eriksen, Kirsten T. ; Tjønneland, Anne ; Peeters, Petra H ; Bueno-de-Mesquita, Bas ; Plusquin, Michelle ; Key, Timothy J ; Jaensch, Andrea ; Nagel, Gabriele ; Lang, Alois ; Wang, Meng ; Tsai, Ming-Yi ; Fournier, Agnes ; Boutron-Ruault, Marie-Christine ; Baglietto, Laura ; Grioni, Sara ; Marcon, Alessandro ; Krogh, Vittorio ; Ricceri, Fulvio ; Sacerdote, Carlotta ; Migliore, Enrica ; Tamayo-Uria, Ibon ; Amiano, Pilar ; Dorronsoro, Miren ; Vermeulen, Roel ; Sokhi, Ranjeet ; Keuken, Menno ; de Hoogh, Kees ; Beelen, Rob ; Vineis, Paolo ; Cesaroni, Giulia ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole. / Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. In: Environmental Health Perspectives. 2017 ; Vol. 125, No. 10. pp. 1-14.

Bibtex

@article{dda78565a35d44d7831d287f36d99234,
title = "Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project",
abstract = "BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95{\%} confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95{\%} CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95{\%} CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95{\%} CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95{\%} CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.",
keywords = "Journal Article",
author = "Andersen, {Zorana J.} and Massimo Stafoggia and Gudrun Weinmayr and Marie Pedersen and Claudia Galassi and J{\o}rgensen, {Jeanette T.} and Anna Oudin and Bertil Forsberg and David Olsson and Bente Oftedal and {Marit Aasvang}, Gunn and Geir Aamodt and Andrei Pyko and G{\"o}ran Pershagen and Michal Korek and {De Faire}, Ulf and Pedersen, {Nancy L} and Claes-G{\"o}ran {\"O}stenson and Laura Fratiglioni and Eriksen, {Kirsten T.} and Anne Tj{\o}nneland and Peeters, {Petra H} and Bas Bueno-de-Mesquita and Michelle Plusquin and Key, {Timothy J} and Andrea Jaensch and Gabriele Nagel and Alois Lang and Meng Wang and Ming-Yi Tsai and Agnes Fournier and Marie-Christine Boutron-Ruault and Laura Baglietto and Sara Grioni and Alessandro Marcon and Vittorio Krogh and Fulvio Ricceri and Carlotta Sacerdote and Enrica Migliore and Ibon Tamayo-Uria and Pilar Amiano and Miren Dorronsoro and Roel Vermeulen and Ranjeet Sokhi and Menno Keuken and {de Hoogh}, Kees and Rob Beelen and Paolo Vineis and Giulia Cesaroni and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen",
year = "2017",
month = "10",
day = "13",
doi = "10.1289/EHP1742",
language = "English",
volume = "125",
pages = "1--14",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "National Institute of Environmental Health Sciences",
number = "10",

}

RIS

TY - JOUR

T1 - Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project

AU - Andersen, Zorana J.

AU - Stafoggia, Massimo

AU - Weinmayr, Gudrun

AU - Pedersen, Marie

AU - Galassi, Claudia

AU - Jørgensen, Jeanette T.

AU - Oudin, Anna

AU - Forsberg, Bertil

AU - Olsson, David

AU - Oftedal, Bente

AU - Marit Aasvang, Gunn

AU - Aamodt, Geir

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - De Faire, Ulf

AU - Pedersen, Nancy L

AU - Östenson, Claes-Göran

AU - Fratiglioni, Laura

AU - Eriksen, Kirsten T.

AU - Tjønneland, Anne

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, Bas

AU - Plusquin, Michelle

AU - Key, Timothy J

AU - Jaensch, Andrea

AU - Nagel, Gabriele

AU - Lang, Alois

AU - Wang, Meng

AU - Tsai, Ming-Yi

AU - Fournier, Agnes

AU - Boutron-Ruault, Marie-Christine

AU - Baglietto, Laura

AU - Grioni, Sara

AU - Marcon, Alessandro

AU - Krogh, Vittorio

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Migliore, Enrica

AU - Tamayo-Uria, Ibon

AU - Amiano, Pilar

AU - Dorronsoro, Miren

AU - Vermeulen, Roel

AU - Sokhi, Ranjeet

AU - Keuken, Menno

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Vineis, Paolo

AU - Cesaroni, Giulia

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

PY - 2017/10/13

Y1 - 2017/10/13

N2 - BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.

AB - BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.

KW - Journal Article

U2 - 10.1289/EHP1742

DO - 10.1289/EHP1742

M3 - Journal article

VL - 125

SP - 1

EP - 14

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 10

M1 - 107005

ER -

ID: 184770308