Long-term exposure to fine particulate matter and breast cancer incidence in the Danish nurse cohort study
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Long-term exposure to fine particulate matter and breast cancer incidence in the Danish nurse cohort study. / Andersen, Zorana Jovanovic; Ravnskjær, Line; Andersen, Klaus Kaae; Loft, Steffen; Brandt, Jørgen; Becker, Thomas; Ketzel, Matthias; Hertel, Ole; Lynge, Elsebeth; Bräuner, Elvira Vaclavik.
In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 26, No. 3, 03.2017, p. 428-430.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Long-term exposure to fine particulate matter and breast cancer incidence in the Danish nurse cohort study
AU - Andersen, Zorana Jovanovic
AU - Ravnskjær, Line
AU - Andersen, Klaus Kaae
AU - Loft, Steffen
AU - Brandt, Jørgen
AU - Becker, Thomas
AU - Ketzel, Matthias
AU - Hertel, Ole
AU - Lynge, Elsebeth
AU - Bräuner, Elvira Vaclavik
N1 - Copyright ©2016, American Association for Cancer Research.
PY - 2017/3
Y1 - 2017/3
N2 - BACKGROUND: An association between air pollution and breast cancer risk has been suggested but evidence is sparse and inconclusive.METHODS: We included 22,877 female nurses from the Danish Nurse cohort who were recruited in 1993 or 1999, and followed them for incidence of breast cancer (N=1,145) until 2013 in the Danish Cancer Register. We estimated annual mean concentrations of particulate matter with diameter < 2.5 µg/m3 (PM2.5) and < 10 µg/m3 (PM10), and nitrogen dioxide (NO2) at nurses' residences since 1990 using an atmospheric chemistry transport model. We examined the association between the 3-year running mean of each pollutant and breast cancer incidence using a time-varying Cox regression.RESULTS: We found no association between breast cancer and PM2.5 (hazard ratio; 95% confidence interval: 0.99; 0.94-1.10 per interquartile range of 3.3 µg/m3), PM10 (1.02; 0.94-1.10 per 2.9 µg/m3) or NO2 (0.99; 0.93-1.05 per 7.4 µg/m3).CONCLUSIONS: Air pollution is not associated with breast cancer risk.IMPACT: Exposure to air pollution in adulthood does not increase the risk of breast cancer, but more data on the effects of early exposure, before first birth, are needed.
AB - BACKGROUND: An association between air pollution and breast cancer risk has been suggested but evidence is sparse and inconclusive.METHODS: We included 22,877 female nurses from the Danish Nurse cohort who were recruited in 1993 or 1999, and followed them for incidence of breast cancer (N=1,145) until 2013 in the Danish Cancer Register. We estimated annual mean concentrations of particulate matter with diameter < 2.5 µg/m3 (PM2.5) and < 10 µg/m3 (PM10), and nitrogen dioxide (NO2) at nurses' residences since 1990 using an atmospheric chemistry transport model. We examined the association between the 3-year running mean of each pollutant and breast cancer incidence using a time-varying Cox regression.RESULTS: We found no association between breast cancer and PM2.5 (hazard ratio; 95% confidence interval: 0.99; 0.94-1.10 per interquartile range of 3.3 µg/m3), PM10 (1.02; 0.94-1.10 per 2.9 µg/m3) or NO2 (0.99; 0.93-1.05 per 7.4 µg/m3).CONCLUSIONS: Air pollution is not associated with breast cancer risk.IMPACT: Exposure to air pollution in adulthood does not increase the risk of breast cancer, but more data on the effects of early exposure, before first birth, are needed.
U2 - 10.1158/1055-9965.EPI-16-0578
DO - 10.1158/1055-9965.EPI-16-0578
M3 - Letter
C2 - 27913396
VL - 26
SP - 428
EP - 430
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
SN - 1055-9965
IS - 3
ER -
ID: 169728769