Long-term exposure to road traffic noise and all-cause and cause-specific mortality: a Danish Nurse Cohort study
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Long-term exposure to road traffic noise and all-cause and cause-specific mortality : a Danish Nurse Cohort study. / Cole-Hunter, Tom; So, Rina; Amini, Heresh; Backalarz, Claus; Brandt, Jørgen; Bräuner, Elvira Vaclavik; Hertel, Ole; Jensen, Steen Solvang; Jørgensen, Jeanette Therming; Ketzel, Matthias; Laursen, Jens Elgaard; Lim, Youn-Hee; Loft, Steffen; Mehta, Amar; Mortensen, Laust H; Simonsen, Mette Kildevæld; Sisgaard, Torben; Westendorp, Rudi; Andersen, Zorana Jovanovic.
In: The Science of the Total Environment, Vol. 820, 153057, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term exposure to road traffic noise and all-cause and cause-specific mortality
T2 - a Danish Nurse Cohort study
AU - Cole-Hunter, Tom
AU - So, Rina
AU - Amini, Heresh
AU - Backalarz, Claus
AU - Brandt, Jørgen
AU - Bräuner, Elvira Vaclavik
AU - Hertel, Ole
AU - Jensen, Steen Solvang
AU - Jørgensen, Jeanette Therming
AU - Ketzel, Matthias
AU - Laursen, Jens Elgaard
AU - Lim, Youn-Hee
AU - Loft, Steffen
AU - Mehta, Amar
AU - Mortensen, Laust H
AU - Simonsen, Mette Kildevæld
AU - Sisgaard, Torben
AU - Westendorp, Rudi
AU - Andersen, Zorana Jovanovic
N1 - Copyright © 2021. Published by Elsevier B.V.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Long-term road traffic noise exposure is linked to cardio-metabolic disease morbidity, whereas evidence on mortality remains limited.OBJECTIVES: We investigated association of long-term exposure to road traffic noise with all-cause and cause-specific mortality.METHODS: We linked 22,858 females from the Danish Nurse Cohort (DNC), recruited into the Danish Register of Causes of Death up to 2014. Road traffic noise levels since 1970 were modelled by Nord2000 as the annual mean of a weighted 24 h average (Lden). Cox regression models examined the associations between Lden (5-year and 23-year means) and all-cause and cause-specific mortalities, adjusting for lifestyle and exposure to PM2.5 (particulate matter with diameter < 2.5 μm) and NO2 (nitrogen dioxide).RESULTS: During follow-up (mean 17.4 years), 3902 nurses died: 1622 from cancer, 922 from CVDs (289 from stroke), 338 from respiratory diseases (186 from chronic obstructive pulmonary disease, 114 from lower respiratory tract infections [ALRIs]), 156 from dementia, 95 from psychiatric disorders, and 79 from diabetes. Hazard ratios (95% confidence intervals) for all-cause mortality from fully-adjusted models were 1.06 (1.01, 1.11) and 1.09 (1.03, 1.15) per 10 dB of 5-year and 23-year mean Lden, respectively, which attenuated slightly in our main model (fully-adjusted plus PM2.5: 1.04 [1.00, 1.10]; 1.08 [1.02, 1.13]). Main model estimates suggested the strongest associations between 5-year mean Lden and diabetes (1.14: 0.81, 1.61), ALRIs (1.13: 0.84, 1.54), dementia (1.12: 0.90, 1.38), and stroke (1.10: 0.91, 1.31), whereas associations with 23-year mean Lden were suggested for respiratory diseases (1.15: 0.95, 1.39), psychiatric disorders (1.11: 0.78, 1.59), and all cancers (1.08: 0.99, 1.17).DISCUSSION: Among the female nurses from the DNC, we observed that long-term exposure to road traffic noise led to premature mortality, independently of air pollution, and its adverse effects may extend well beyond those on the cardio-metabolic system to include respiratory diseases, cancer, neurodegenerative and psychiatric disorders.
AB - BACKGROUND: Long-term road traffic noise exposure is linked to cardio-metabolic disease morbidity, whereas evidence on mortality remains limited.OBJECTIVES: We investigated association of long-term exposure to road traffic noise with all-cause and cause-specific mortality.METHODS: We linked 22,858 females from the Danish Nurse Cohort (DNC), recruited into the Danish Register of Causes of Death up to 2014. Road traffic noise levels since 1970 were modelled by Nord2000 as the annual mean of a weighted 24 h average (Lden). Cox regression models examined the associations between Lden (5-year and 23-year means) and all-cause and cause-specific mortalities, adjusting for lifestyle and exposure to PM2.5 (particulate matter with diameter < 2.5 μm) and NO2 (nitrogen dioxide).RESULTS: During follow-up (mean 17.4 years), 3902 nurses died: 1622 from cancer, 922 from CVDs (289 from stroke), 338 from respiratory diseases (186 from chronic obstructive pulmonary disease, 114 from lower respiratory tract infections [ALRIs]), 156 from dementia, 95 from psychiatric disorders, and 79 from diabetes. Hazard ratios (95% confidence intervals) for all-cause mortality from fully-adjusted models were 1.06 (1.01, 1.11) and 1.09 (1.03, 1.15) per 10 dB of 5-year and 23-year mean Lden, respectively, which attenuated slightly in our main model (fully-adjusted plus PM2.5: 1.04 [1.00, 1.10]; 1.08 [1.02, 1.13]). Main model estimates suggested the strongest associations between 5-year mean Lden and diabetes (1.14: 0.81, 1.61), ALRIs (1.13: 0.84, 1.54), dementia (1.12: 0.90, 1.38), and stroke (1.10: 0.91, 1.31), whereas associations with 23-year mean Lden were suggested for respiratory diseases (1.15: 0.95, 1.39), psychiatric disorders (1.11: 0.78, 1.59), and all cancers (1.08: 0.99, 1.17).DISCUSSION: Among the female nurses from the DNC, we observed that long-term exposure to road traffic noise led to premature mortality, independently of air pollution, and its adverse effects may extend well beyond those on the cardio-metabolic system to include respiratory diseases, cancer, neurodegenerative and psychiatric disorders.
U2 - 10.1016/j.scitotenv.2022.153057
DO - 10.1016/j.scitotenv.2022.153057
M3 - Journal article
C2 - 35031374
VL - 820
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
M1 - 153057
ER -
ID: 290060556