Low-level efficacy of cosmetic preservatives

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Low-level efficacy of cosmetic preservatives. / Lundov, M D; Johansen, J D; Zachariae, C; Moesby, Lise.

In: International Journal of Cosmetic Science, Vol. 33, No. 2, 2011, p. 190-6.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Lundov, MD, Johansen, JD, Zachariae, C & Moesby, L 2011, 'Low-level efficacy of cosmetic preservatives', International Journal of Cosmetic Science, vol. 33, no. 2, pp. 190-6. https://doi.org/10.1111/j.1468-2494.2010.00619.x

APA

Lundov, M. D., Johansen, J. D., Zachariae, C., & Moesby, L. (2011). Low-level efficacy of cosmetic preservatives. International Journal of Cosmetic Science, 33(2), 190-6. https://doi.org/10.1111/j.1468-2494.2010.00619.x

Vancouver

Lundov MD, Johansen JD, Zachariae C, Moesby L. Low-level efficacy of cosmetic preservatives. International Journal of Cosmetic Science. 2011;33(2):190-6. https://doi.org/10.1111/j.1468-2494.2010.00619.x

Author

Lundov, M D ; Johansen, J D ; Zachariae, C ; Moesby, Lise. / Low-level efficacy of cosmetic preservatives. In: International Journal of Cosmetic Science. 2011 ; Vol. 33, No. 2. pp. 190-6.

Bibtex

@article{61361f35bbdf4bcd996f1159896c530c,
title = "Low-level efficacy of cosmetic preservatives",
abstract = "Preservation using combinations of preservatives has several advantages. This study shows that the concentration of some of the most frequently used allergenic preservatives can be markedly lowered when they are combined with phenoxyethanol. The antimicrobial efficacy of cosmetic preservatives and known allergens of various potency [diazolidinyl urea, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), methylisothiazolinone (MI) and phenoxyethanol] was tested alone and in various combinations of two or three preservatives together. The preservatives were tested for minimum inhibitory concentration (MIC) values and possible synergy using fractional inhibitory concentration. MCI/MI was the only preservative showing low-level MIC against all four tested microorganisms: Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. Different combinations of the preservatives indicated additive effects against the microorganisms. No combination of preservatives showed any inhibitory action on each other. Challenge tests with different concentrations and combinations were performed in a cosmetic cream. Diazolidinyl urea and MCI/MI alone were ineffective against C. albicans in a challenge test at concentrations up to 16 times higher than the observed MIC values. When combining phenoxyethanol with either one of the allergenic preservatives diazolidinyl urea, MCI/MI or MI, the cosmetic cream was adequately preserved at concentrations well below the preservatives' MIC values as well as 10-20 times below the maximum permitted concentrations. By using combinations of preservatives, effective preservation can be achieved with lower concentrations of allergenic preservatives.",
keywords = "Anti-Infective Agents, Candida albicans, Cosmetics, Humans, Microbial Sensitivity Tests, Preservatives, Pharmaceutical, Pseudomonas aeruginosa, Staphylococcus aureus, The Faculty of Pharmaceutical Sciences",
author = "Lundov, {M D} and Johansen, {J D} and C Zachariae and Lise Moesby",
note = "{\circledC} 2011 The Authors. ICS {\circledC} 2011 Society of Cosmetic Scientists and the Soci{\'e}t{\'e} Fran{\cc}aise de Cosm{\'e}tologie.",
year = "2011",
doi = "10.1111/j.1468-2494.2010.00619.x",
language = "English",
volume = "33",
pages = "190--6",
journal = "International Journal of Cosmetic Science",
issn = "0142-5463",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Low-level efficacy of cosmetic preservatives

AU - Lundov, M D

AU - Johansen, J D

AU - Zachariae, C

AU - Moesby, Lise

N1 - © 2011 The Authors. ICS © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

PY - 2011

Y1 - 2011

N2 - Preservation using combinations of preservatives has several advantages. This study shows that the concentration of some of the most frequently used allergenic preservatives can be markedly lowered when they are combined with phenoxyethanol. The antimicrobial efficacy of cosmetic preservatives and known allergens of various potency [diazolidinyl urea, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), methylisothiazolinone (MI) and phenoxyethanol] was tested alone and in various combinations of two or three preservatives together. The preservatives were tested for minimum inhibitory concentration (MIC) values and possible synergy using fractional inhibitory concentration. MCI/MI was the only preservative showing low-level MIC against all four tested microorganisms: Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. Different combinations of the preservatives indicated additive effects against the microorganisms. No combination of preservatives showed any inhibitory action on each other. Challenge tests with different concentrations and combinations were performed in a cosmetic cream. Diazolidinyl urea and MCI/MI alone were ineffective against C. albicans in a challenge test at concentrations up to 16 times higher than the observed MIC values. When combining phenoxyethanol with either one of the allergenic preservatives diazolidinyl urea, MCI/MI or MI, the cosmetic cream was adequately preserved at concentrations well below the preservatives' MIC values as well as 10-20 times below the maximum permitted concentrations. By using combinations of preservatives, effective preservation can be achieved with lower concentrations of allergenic preservatives.

AB - Preservation using combinations of preservatives has several advantages. This study shows that the concentration of some of the most frequently used allergenic preservatives can be markedly lowered when they are combined with phenoxyethanol. The antimicrobial efficacy of cosmetic preservatives and known allergens of various potency [diazolidinyl urea, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), methylisothiazolinone (MI) and phenoxyethanol] was tested alone and in various combinations of two or three preservatives together. The preservatives were tested for minimum inhibitory concentration (MIC) values and possible synergy using fractional inhibitory concentration. MCI/MI was the only preservative showing low-level MIC against all four tested microorganisms: Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. Different combinations of the preservatives indicated additive effects against the microorganisms. No combination of preservatives showed any inhibitory action on each other. Challenge tests with different concentrations and combinations were performed in a cosmetic cream. Diazolidinyl urea and MCI/MI alone were ineffective against C. albicans in a challenge test at concentrations up to 16 times higher than the observed MIC values. When combining phenoxyethanol with either one of the allergenic preservatives diazolidinyl urea, MCI/MI or MI, the cosmetic cream was adequately preserved at concentrations well below the preservatives' MIC values as well as 10-20 times below the maximum permitted concentrations. By using combinations of preservatives, effective preservation can be achieved with lower concentrations of allergenic preservatives.

KW - Anti-Infective Agents

KW - Candida albicans

KW - Cosmetics

KW - Humans

KW - Microbial Sensitivity Tests

KW - Preservatives, Pharmaceutical

KW - Pseudomonas aeruginosa

KW - Staphylococcus aureus

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1111/j.1468-2494.2010.00619.x

DO - 10.1111/j.1468-2494.2010.00619.x

M3 - Journal article

VL - 33

SP - 190

EP - 196

JO - International Journal of Cosmetic Science

JF - International Journal of Cosmetic Science

SN - 0142-5463

IS - 2

ER -

ID: 38100112