Male origin microchimerism and brain cancer: a case-cohort study

Research output: Contribution to journalJournal articlepeer-review

Standard

Male origin microchimerism and brain cancer : a case-cohort study. / Kamper-Jørgensen, Mads; Jakobsen, Marianne Antonius; Tjønneland, Anne; Skjøth-Rasmussen, Jane; Petersen, Gitte Lindved; Hallum, Sara.

In: Journal of Cancer Research and Clinical Oncology, 2023, p. 5469–5474.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kamper-Jørgensen, M, Jakobsen, MA, Tjønneland, A, Skjøth-Rasmussen, J, Petersen, GL & Hallum, S 2023, 'Male origin microchimerism and brain cancer: a case-cohort study', Journal of Cancer Research and Clinical Oncology, pp. 5469–5474. https://doi.org/10.1007/s00432-022-04494-0

APA

Kamper-Jørgensen, M., Jakobsen, M. A., Tjønneland, A., Skjøth-Rasmussen, J., Petersen, G. L., & Hallum, S. (2023). Male origin microchimerism and brain cancer: a case-cohort study. Journal of Cancer Research and Clinical Oncology, 5469–5474. https://doi.org/10.1007/s00432-022-04494-0

Vancouver

Kamper-Jørgensen M, Jakobsen MA, Tjønneland A, Skjøth-Rasmussen J, Petersen GL, Hallum S. Male origin microchimerism and brain cancer: a case-cohort study. Journal of Cancer Research and Clinical Oncology. 2023;5469–5474. https://doi.org/10.1007/s00432-022-04494-0

Author

Kamper-Jørgensen, Mads ; Jakobsen, Marianne Antonius ; Tjønneland, Anne ; Skjøth-Rasmussen, Jane ; Petersen, Gitte Lindved ; Hallum, Sara. / Male origin microchimerism and brain cancer : a case-cohort study. In: Journal of Cancer Research and Clinical Oncology. 2023 ; pp. 5469–5474.

Bibtex

@article{eb471f34b3a1471698a604227b149ee5,
title = "Male origin microchimerism and brain cancer: a case-cohort study",
abstract = "BACKGROUND: Despite considerable research effort, causes of brain cancer are largely unknown. Male brain cancer predominance and reduced brain cancer risk with increasing parity among women, however, support a favourable role of pregnancy. We set out to determine whether fetal-origin microchimerism, namely the presence and long-term persistence of fetal cells, likely obtained via natural trafficking across the placenta during pregnancy, associates with reduced risk of brain cancer in women.METHODS: Using a case-cohort design, we sampled 505 middle-aged women randomly at baseline in the Diet, Cancer and Health cohort (controls), and 73 women with incident brain cancer diagnosed during follow-up in the Danish Cancer Registry (cases). Male origin microchimerism was determined by presence of Y chromosome sequences in female blood samples. Data were analysed using weighted proportional Hazards regression, yielding Hazard Ratios with 95% confidence intervals.RESULTS: Compared with male origin microchimerism negative women, positive women had half the risk of developing brain cancer (Hazard Ratio = 0.50 [0.33-0.77]). Sensitivity analyses support that our findings are unlikely due to bias or chance.CONCLUSION: Here, for the first time, we demonstrate half the risk of brain cancer in male origin microchimerism positive compared with negative women. Our findings resemble those of previous studies of male origin microchimerism and other female cancers.",
author = "Mads Kamper-J{\o}rgensen and Jakobsen, {Marianne Antonius} and Anne Tj{\o}nneland and Jane Skj{\o}th-Rasmussen and Petersen, {Gitte Lindved} and Sara Hallum",
note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2023",
doi = "10.1007/s00432-022-04494-0",
language = "English",
pages = "5469–5474",
journal = "Zeitschrift fur Krebsforschung",
issn = "0171-5216",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Male origin microchimerism and brain cancer

T2 - a case-cohort study

AU - Kamper-Jørgensen, Mads

AU - Jakobsen, Marianne Antonius

AU - Tjønneland, Anne

AU - Skjøth-Rasmussen, Jane

AU - Petersen, Gitte Lindved

AU - Hallum, Sara

N1 - © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Despite considerable research effort, causes of brain cancer are largely unknown. Male brain cancer predominance and reduced brain cancer risk with increasing parity among women, however, support a favourable role of pregnancy. We set out to determine whether fetal-origin microchimerism, namely the presence and long-term persistence of fetal cells, likely obtained via natural trafficking across the placenta during pregnancy, associates with reduced risk of brain cancer in women.METHODS: Using a case-cohort design, we sampled 505 middle-aged women randomly at baseline in the Diet, Cancer and Health cohort (controls), and 73 women with incident brain cancer diagnosed during follow-up in the Danish Cancer Registry (cases). Male origin microchimerism was determined by presence of Y chromosome sequences in female blood samples. Data were analysed using weighted proportional Hazards regression, yielding Hazard Ratios with 95% confidence intervals.RESULTS: Compared with male origin microchimerism negative women, positive women had half the risk of developing brain cancer (Hazard Ratio = 0.50 [0.33-0.77]). Sensitivity analyses support that our findings are unlikely due to bias or chance.CONCLUSION: Here, for the first time, we demonstrate half the risk of brain cancer in male origin microchimerism positive compared with negative women. Our findings resemble those of previous studies of male origin microchimerism and other female cancers.

AB - BACKGROUND: Despite considerable research effort, causes of brain cancer are largely unknown. Male brain cancer predominance and reduced brain cancer risk with increasing parity among women, however, support a favourable role of pregnancy. We set out to determine whether fetal-origin microchimerism, namely the presence and long-term persistence of fetal cells, likely obtained via natural trafficking across the placenta during pregnancy, associates with reduced risk of brain cancer in women.METHODS: Using a case-cohort design, we sampled 505 middle-aged women randomly at baseline in the Diet, Cancer and Health cohort (controls), and 73 women with incident brain cancer diagnosed during follow-up in the Danish Cancer Registry (cases). Male origin microchimerism was determined by presence of Y chromosome sequences in female blood samples. Data were analysed using weighted proportional Hazards regression, yielding Hazard Ratios with 95% confidence intervals.RESULTS: Compared with male origin microchimerism negative women, positive women had half the risk of developing brain cancer (Hazard Ratio = 0.50 [0.33-0.77]). Sensitivity analyses support that our findings are unlikely due to bias or chance.CONCLUSION: Here, for the first time, we demonstrate half the risk of brain cancer in male origin microchimerism positive compared with negative women. Our findings resemble those of previous studies of male origin microchimerism and other female cancers.

U2 - 10.1007/s00432-022-04494-0

DO - 10.1007/s00432-022-04494-0

M3 - Journal article

C2 - 36462037

SP - 5469

EP - 5474

JO - Zeitschrift fur Krebsforschung

JF - Zeitschrift fur Krebsforschung

SN - 0171-5216

ER -

ID: 327679294