Maternal Body Weight and Inflammation Among Offspring in Late Middle Age
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Higher maternal body mass index (BMI) is associated with offspring adiposity; however the effect of maternal BMI on subsequent inflammatory concentrations among offspring is unexplored. The aim is to estimate the direct and indirect effects of maternal pre-pregnancy BMI on C-Reactive protein (CRP) and Interleukin-6 (IL-6) concentrations of male offspring in late middle age. The study is based on 598 Danish males from the Copenhagen Aging and Midlife Biobank (mean age, 55.2 years) with comprehensive historical data from birth. Path analysis is employed to estimate direct and indirect effects. A 10 % higher maternal pre-pregnancy BMI was associated with 7 % higher offspring CRP (factor 1.07; 95 % C.I. 1.01, 1.12) and 3 % higher IL-6 (factor 1.03; 95 % C.I. 1.01, 1.06). The total effect was entirely mediated through the effect of maternal BMI on offspring’s BMI in adulthood but not through offspring size at birth.
|Publication status||Published - 2015|
|Event||Gerontological Society of America: 68th Annual Meeting - Orlando, Florida, United States|
Duration: 18 Nov 2015 → …
|Conference||Gerontological Society of America: 68th Annual Meeting|
|Period||18/11/2015 → …|