Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts
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Maternal complications in pregnancy and wheezing in early childhood : a pooled analysis of 14 birth cohorts. / Zugna, Daniela; Galassi, Claudia; Annesi-Maesano, Isabella; Baïz, Nour; Barros, Henrique; Basterrechea, Mikel; Correia, Sofia; Duijts, Liesbeth; Esplugues, Ana; Fantini, Maria Pia; Forastiere, Francesco; Gascon, Mireia; Gori, Davide; Inskip, Hazel; Larsen, Pernille S; Mommers, Monique; Andersen, Anne-Marie Nybo; Penders, John; Petersen, Maria S; Pike, Katharine; Porta, Daniela; Sonnenschein-van der Voort, Agnes; Steuerwald, Ulrike; Sunyer, Jordi; Torrent, Maties; Vrijheid, Martine; Richiardi, Lorenzo; Rusconi, Franca.
In: International Journal of Epidemiology, Vol. 44, No. 1, 02.2015, p. 199-208.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal complications in pregnancy and wheezing in early childhood
T2 - a pooled analysis of 14 birth cohorts
AU - Zugna, Daniela
AU - Galassi, Claudia
AU - Annesi-Maesano, Isabella
AU - Baïz, Nour
AU - Barros, Henrique
AU - Basterrechea, Mikel
AU - Correia, Sofia
AU - Duijts, Liesbeth
AU - Esplugues, Ana
AU - Fantini, Maria Pia
AU - Forastiere, Francesco
AU - Gascon, Mireia
AU - Gori, Davide
AU - Inskip, Hazel
AU - Larsen, Pernille S
AU - Mommers, Monique
AU - Andersen, Anne-Marie Nybo
AU - Penders, John
AU - Petersen, Maria S
AU - Pike, Katharine
AU - Porta, Daniela
AU - Sonnenschein-van der Voort, Agnes
AU - Steuerwald, Ulrike
AU - Sunyer, Jordi
AU - Torrent, Maties
AU - Vrijheid, Martine
AU - Richiardi, Lorenzo
AU - Rusconi, Franca
N1 - © The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
PY - 2015/2
Y1 - 2015/2
N2 - BACKGROUND: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient.METHODS: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index ≥ 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model.RESULTS: The study included 85509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P=0.027).CONCLUSIONS: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.
AB - BACKGROUND: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient.METHODS: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabetes, as well as pre-pregnancy overweight (body mass index between 25 and 29.9) and obesity (body mass index ≥ 30) compared with normal weight (body mass index between 18.5 and 24.9). Outcomes included both ever and recurrent wheezing from birth up to 12-24 months of age. Cohort-specific crude and adjusted risk ratios (RR) were calculated using log-binomial regression models and then pooled using a random effects model.RESULTS: The study included 85509 subjects. Cohort-specific prevalence of ever wheezing varied from 20.0% to 47.3%, and of recurrent wheezing from 3.0% to 14.3%. Adjusted pooled RR for ever and recurrent wheezing were: 1.02 (95% CI: 0.98-1.06) and 1.20 (95% CI: 0.98-1.47) for hypertensive disorders; 1.09 (95% CI: 1.01-1.18) and 1.23 (95% CI: 1.07-1.43) for preeclampsia; 1.04 (95% CI: 0.97-1.13) and 1.24 (95% CI: 0.86-1.79) for diabetes; 1.08 (95% CI: 1.05-1.11) and 1.19 (95% CI: 1.12-1.26) for overweight; 1.12 (95% CI: 1.08-1.17) and 1.16 (95% CI: 0.97-1.39) for obesity. No heterogeneity was found in RR estimates among the cohorts, except for diabetes and recurrent wheezing (P=0.027).CONCLUSIONS: Preeclampsia, maternal pre-pregnancy overweight and obesity are associated with an increase risk of wheezing in the offspring.
U2 - 10.1093/ije/dyu260
DO - 10.1093/ije/dyu260
M3 - Journal article
C2 - 25626439
VL - 44
SP - 199
EP - 208
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 1
ER -
ID: 135533146