Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. / Forthun, Ingeborg; Wilcox, Allen J.; Strandberg-Larsen, Katrine; Moster, Dag; Nohr, Ellen A.; Lie, Rolv Terje; Surén, Pål; Tollånes, Mette C.

In: Pediatrics, Vol. 138, No. 4, e20160874 , 10.2016, p. 1-11.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Forthun, I, Wilcox, AJ, Strandberg-Larsen, K, Moster, D, Nohr, EA, Lie, RT, Surén, P & Tollånes, MC 2016, 'Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring', Pediatrics, vol. 138, no. 4, e20160874 , pp. 1-11. https://doi.org/10.1542/peds.2016-0874

APA

Forthun, I., Wilcox, A. J., Strandberg-Larsen, K., Moster, D., Nohr, E. A., Lie, R. T., ... Tollånes, M. C. (2016). Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. Pediatrics, 138(4), 1-11. [e20160874 ]. https://doi.org/10.1542/peds.2016-0874

Vancouver

Forthun I, Wilcox AJ, Strandberg-Larsen K, Moster D, Nohr EA, Lie RT et al. Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. Pediatrics. 2016 Oct;138(4):1-11. e20160874 . https://doi.org/10.1542/peds.2016-0874

Author

Forthun, Ingeborg ; Wilcox, Allen J. ; Strandberg-Larsen, Katrine ; Moster, Dag ; Nohr, Ellen A. ; Lie, Rolv Terje ; Surén, Pål ; Tollånes, Mette C. / Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring. In: Pediatrics. 2016 ; Vol. 138, No. 4. pp. 1-11.

Bibtex

@article{89d24431698741d588077e06ba209cbf,
title = "Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring",
abstract = "OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring. METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5–22.9), upper normal weight (BMI 23.0–24.9), overweight (BMI 25.0–29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models. RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40{\%} excess risk of having a child with CP (relative risk [RR], 1.35; 95{\%} confidence interval [CI], 1.03–1.78). Excess risk was 60{\%} (RR, 1.56; 95{\%} CI, 1.21–2.01) for overweight mothers and 60{\%} (RR, 1.55; 95{\%} CI 1.11–2.18) for obese mothers. The risk of CP increased ∼4{\%} for each unit increase in BMI (RR, 1.04; 95{\%} CI, 1.02–1.06). Estimates changed little with adjustment for mother’s occupational status, age, and smoking habits. CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.",
author = "Ingeborg Forthun and Wilcox, {Allen J.} and Katrine Strandberg-Larsen and Dag Moster and Nohr, {Ellen A.} and Lie, {Rolv Terje} and P{\aa}l Sur{\'e}n and Toll{\aa}nes, {Mette C.}",
year = "2016",
month = "10",
doi = "10.1542/peds.2016-0874",
language = "English",
volume = "138",
pages = "1--11",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "4",

}

RIS

TY - JOUR

T1 - Maternal Prepregnancy BMI and Risk of Cerebral Palsy in Offspring

AU - Forthun, Ingeborg

AU - Wilcox, Allen J.

AU - Strandberg-Larsen, Katrine

AU - Moster, Dag

AU - Nohr, Ellen A.

AU - Lie, Rolv Terje

AU - Surén, Pål

AU - Tollånes, Mette C.

PY - 2016/10

Y1 - 2016/10

N2 - OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring. METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5–22.9), upper normal weight (BMI 23.0–24.9), overweight (BMI 25.0–29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models. RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40% excess risk of having a child with CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03–1.78). Excess risk was 60% (RR, 1.56; 95% CI, 1.21–2.01) for overweight mothers and 60% (RR, 1.55; 95% CI 1.11–2.18) for obese mothers. The risk of CP increased ∼4% for each unit increase in BMI (RR, 1.04; 95% CI, 1.02–1.06). Estimates changed little with adjustment for mother’s occupational status, age, and smoking habits. CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.

AB - OBJECTIVES: To investigate the association between maternal pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring. METHODS: The study population consisted of 188 788 children in the Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based, prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Prepregnancy BMI was classified as underweight (BMI <18.5), lower normal weight (BMI 18.5–22.9), upper normal weight (BMI 23.0–24.9), overweight (BMI 25.0–29.9), and obese (BMI ≥30). CP diagnoses were obtained from the national CP registries. Associations between maternal prepregnancy BMI and CP in offspring were investigated by using log-binomial regression models. RESULTS: The 2 cohorts had 390 eligible cases of CP (2.1 per 1000 live-born children). Compared with mothers in the lower normal weight group, mothers in the upper normal group had a 40% excess risk of having a child with CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03–1.78). Excess risk was 60% (RR, 1.56; 95% CI, 1.21–2.01) for overweight mothers and 60% (RR, 1.55; 95% CI 1.11–2.18) for obese mothers. The risk of CP increased ∼4% for each unit increase in BMI (RR, 1.04; 95% CI, 1.02–1.06). Estimates changed little with adjustment for mother’s occupational status, age, and smoking habits. CONCLUSIONS: Higher prepregnancy maternal BMI was associated with increased risk of CP in offspring.

U2 - 10.1542/peds.2016-0874

DO - 10.1542/peds.2016-0874

M3 - Journal article

C2 - 27609826

VL - 138

SP - 1

EP - 11

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

M1 - e20160874

ER -

ID: 167809780