TY - JOUR

T1 - Mortality among patients treated for aneurysmal subarachnoid hemorrhage in Eastern Denmark 2017-2019

AU - Stauning, Agnes T.

AU - Eriksson, Frank

AU - Benndorf, Goetz

AU - Holst, Anders

AU - Hauerberg, John

AU - Stavngaard, Trine

AU - Poulsgaard, Lars

AU - Rochat, Per

AU - Eskesen, Vagn

AU - Birkeland, Peter

AU - Mathiesen, Tiit

AU - Munch, Tina N.

PY - 2022

Y1 - 2022

N2 - Objective The aim of the study was to investigate (1) the 30-day, 3-month, and 12-month cumulative mortalities for patients who underwent aneurysm occlusion, and (2) the causes of death, and (3) the potential risk factors for death.Methods All patients who underwent surgical clipping or endovascular treatment of a ruptured aneurysm at Copenhagen University Hospital, during the period of January 1, 2017-December 31, 2019, were included and followed up for 12 months. Data regarding vital status, causes of death, comorbidities, treatment, and clinical presentations on admission was collected. The absolute mortality risk was estimated as a function of time with a 95% confidence interval. The associations between potential risk factors and death were estimated as odds ratios with 95% confidence intervals using logistic regression models.Results A total of 317 patients were included. The overall cumulative mortalities after 30 days, 3 months, and 12 months were 10.7%, 12.9%, and 16.1%, respectively. The most common cause of death was severe primary hemorrhage (52.9%), followed by infections (15.7%) and rebleeding (11.8%). WFNS score > 3 and Fisher score > 3 on admission, preprocedural hydrocephalus, and preprocedural rebleeding were found significantly associated with higher risk of death.Conclusions Considerable mortality was seen. Possible preventable causes accounted for approximately 22% of the deaths. The occurrence of both pre- and postprocedural rebleeding's indicates an opportunity of further improvement of the mortality by (1) further reduction of time from aSAH to aneurysm occlusion and (2) continuous efforts in improving methods of aneurysm occlusion.

AB - Objective The aim of the study was to investigate (1) the 30-day, 3-month, and 12-month cumulative mortalities for patients who underwent aneurysm occlusion, and (2) the causes of death, and (3) the potential risk factors for death.Methods All patients who underwent surgical clipping or endovascular treatment of a ruptured aneurysm at Copenhagen University Hospital, during the period of January 1, 2017-December 31, 2019, were included and followed up for 12 months. Data regarding vital status, causes of death, comorbidities, treatment, and clinical presentations on admission was collected. The absolute mortality risk was estimated as a function of time with a 95% confidence interval. The associations between potential risk factors and death were estimated as odds ratios with 95% confidence intervals using logistic regression models.Results A total of 317 patients were included. The overall cumulative mortalities after 30 days, 3 months, and 12 months were 10.7%, 12.9%, and 16.1%, respectively. The most common cause of death was severe primary hemorrhage (52.9%), followed by infections (15.7%) and rebleeding (11.8%). WFNS score > 3 and Fisher score > 3 on admission, preprocedural hydrocephalus, and preprocedural rebleeding were found significantly associated with higher risk of death.Conclusions Considerable mortality was seen. Possible preventable causes accounted for approximately 22% of the deaths. The occurrence of both pre- and postprocedural rebleeding's indicates an opportunity of further improvement of the mortality by (1) further reduction of time from aSAH to aneurysm occlusion and (2) continuous efforts in improving methods of aneurysm occlusion.

KW - aSAH

KW - Mortality

KW - WNFS score

KW - Endovascular treatment

KW - Surgical clipping

KW - CASE-FATALITY

KW - PREDICTION

KW - VALIDATION

KW - SURGERY

KW - SMOKING

KW - IMPACT

KW - CARE

U2 - 10.1007/s00701-022-05303-w

DO - 10.1007/s00701-022-05303-w

M3 - Journal article

C2 - 35864221

VL - 164

SP - 2419

EP - 2430

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

ER -