Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups. / Christensen, Dirk L; Witte, Daniel R; Kaduka, Lydia; Jørgensen, Marit E; Borch-Johnsen, Knut; Mohan, Viswanathan; Shaw, Jonathan E; Tabák, Adam G; Vistisen, Dorte.
In: Diabetes Care, Vol. 33, No. 3, 2010, p. 580-2.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups
AU - Christensen, Dirk L
AU - Witte, Daniel R
AU - Kaduka, Lydia
AU - Jørgensen, Marit E
AU - Borch-Johnsen, Knut
AU - Mohan, Viswanathan
AU - Shaw, Jonathan E
AU - Tabák, Adam G
AU - Vistisen, Dorte
N1 - Keywords: Adult; Aged; Australia; Confounding Factors (Epidemiology); Denmark; Diabetes Mellitus; Diagnostic Techniques, Endocrine; Ethnic Groups; Female; Great Britain; Greenland; Hemoglobin A, Glycosylated; Humans; India; Kenya; Male; Middle Aged; Prevalence
PY - 2010
Y1 - 2010
N2 - OBJECTIVE To compare screen-detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current oral glucose tolerance test (OGTT)-based and newly proposed A1C-based diagnostic criteria. RESEARCH DESIGN AND METHODS Six studies (1999-2009) from Denmark, the U.K., Australia, Greenland, Kenya, and India were tested for the probability of an A1C > or =6.5% among diabetic case subjects based on an OGTT. The difference in probability between centers was analyzed by logistic regression adjusting for relevant confounders. RESULTS Diabetes prevalence was lower with the A1C-based diagnostic criteria in four of six studies. The probability of an A1C > or =6.5% among OGTT-diagnosed case subjects ranged widely (17.0-78.0%) by study center. Differences in diagnostic agreement between ethnic subgroups in the U.K. study were of the same magnitude as between-country comparisons. CONCLUSIONS A shift to an A1C-based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations.
AB - OBJECTIVE To compare screen-detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current oral glucose tolerance test (OGTT)-based and newly proposed A1C-based diagnostic criteria. RESEARCH DESIGN AND METHODS Six studies (1999-2009) from Denmark, the U.K., Australia, Greenland, Kenya, and India were tested for the probability of an A1C > or =6.5% among diabetic case subjects based on an OGTT. The difference in probability between centers was analyzed by logistic regression adjusting for relevant confounders. RESULTS Diabetes prevalence was lower with the A1C-based diagnostic criteria in four of six studies. The probability of an A1C > or =6.5% among OGTT-diagnosed case subjects ranged widely (17.0-78.0%) by study center. Differences in diagnostic agreement between ethnic subgroups in the U.K. study were of the same magnitude as between-country comparisons. CONCLUSIONS A shift to an A1C-based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations.
KW - Faculty of Health and Medical Sciences
U2 - 10.2337/dc09-1843
DO - 10.2337/dc09-1843
M3 - Journal article
C2 - 20009099
VL - 33
SP - 580
EP - 582
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 3
ER -
ID: 20391057