Neonatal chemokine levels and risk of autism spectrum disorders

Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study

Research output: Contribution to journal › Journal article › Research › peer-review

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Neonatal chemokine levels and risk of autism spectrum disorders : Findings from a Danish historic birth cohort follow-up study. / Abdallah, Morsi; Larsen, Nanna ; Grove, Jakob; Bonefeld-Jørgensen, Eva Cecilie; Nørgaard-Pedersen, Bent; Hougaard, David M; Mortensen, Erik L.

In: Cytokine, Vol. 61, No. 2, 02.2013, p. 370-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Abdallah, M, Larsen, N, Grove, J, Bonefeld-Jørgensen, EC, Nørgaard-Pedersen, B, Hougaard, DM & Mortensen, EL 2013, 'Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study', Cytokine, vol. 61, no. 2, pp. 370-6. https://doi.org/10.1016/j.cyto.2012.11.015

APA

Abdallah, M., Larsen, N., Grove, J., Bonefeld-Jørgensen, E. C., Nørgaard-Pedersen, B., Hougaard, D. M., & Mortensen, E. L. (2013). Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study. Cytokine, 61(2), 370-6. https://doi.org/10.1016/j.cyto.2012.11.015

Vancouver

Abdallah M, Larsen N, Grove J, Bonefeld-Jørgensen EC, Nørgaard-Pedersen B, Hougaard DM et al. Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study. Cytokine. 2013 Feb;61(2):370-6. https://doi.org/10.1016/j.cyto.2012.11.015

Author

Abdallah, Morsi ; Larsen, Nanna ; Grove, Jakob ; Bonefeld-Jørgensen, Eva Cecilie ; Nørgaard-Pedersen, Bent ; Hougaard, David M ; Mortensen, Erik L. / Neonatal chemokine levels and risk of autism spectrum disorders : Findings from a Danish historic birth cohort follow-up study. In: Cytokine. 2013 ; Vol. 61, No. 2. pp. 370-6.

Bibtex

@article{e963e4371dbc4725909814821f6f2c0c,

title = "Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study",

abstract = "A potential role of chemokines in the pathophysiology of Autism Spectrum Disorders (ASDs) has been previously suggested. In a recent study we examined levels of three inflammatory chemokines (MCP-1, MIP-1a and RANTES) in samples of amniotic fluid of children diagnosed later in life with ASD and controls frequency-matched to cases on gender and year of birth. In this follow-up study, levels of the same chemokines were analyzed postnatally in dried blood spot samples from the same subjects utilizing the Danish Newborn Screening Biobank. Crude estimates showed decreased levels of RANTES. In the adjusted estimates, no differences were found in levels of the three examined chemokines in ASD cases compared to controls. Our findings may cautiously suggest an altered cell-mediated immunity during the early neonatal period in ASD. Further research is needed to examine the relationship between maternal/fetal and neonatal chemokine levels and their role in ASD.",

author = "Morsi Abdallah and Nanna Larsen and Jakob Grove and Bonefeld-J{\o}rgensen, {Eva Cecilie} and Bent N{\o}rgaard-Pedersen and Hougaard, {David M} and Mortensen, {Erik L}",

year = "2013",

month = feb,

doi = "10.1016/j.cyto.2012.11.015",

language = "English",

volume = "61",

pages = "370--6",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press",

number = "2",

}

RIS

TY - JOUR

T1 - Neonatal chemokine levels and risk of autism spectrum disorders

T2 - Findings from a Danish historic birth cohort follow-up study

AU - Abdallah, Morsi

AU - Larsen, Nanna

AU - Grove, Jakob

AU - Bonefeld-Jørgensen, Eva Cecilie

AU - Nørgaard-Pedersen, Bent

AU - Hougaard, David M

AU - Mortensen, Erik L

PY - 2013/2

Y1 - 2013/2

N2 - A potential role of chemokines in the pathophysiology of Autism Spectrum Disorders (ASDs) has been previously suggested. In a recent study we examined levels of three inflammatory chemokines (MCP-1, MIP-1a and RANTES) in samples of amniotic fluid of children diagnosed later in life with ASD and controls frequency-matched to cases on gender and year of birth. In this follow-up study, levels of the same chemokines were analyzed postnatally in dried blood spot samples from the same subjects utilizing the Danish Newborn Screening Biobank. Crude estimates showed decreased levels of RANTES. In the adjusted estimates, no differences were found in levels of the three examined chemokines in ASD cases compared to controls. Our findings may cautiously suggest an altered cell-mediated immunity during the early neonatal period in ASD. Further research is needed to examine the relationship between maternal/fetal and neonatal chemokine levels and their role in ASD.

AB - A potential role of chemokines in the pathophysiology of Autism Spectrum Disorders (ASDs) has been previously suggested. In a recent study we examined levels of three inflammatory chemokines (MCP-1, MIP-1a and RANTES) in samples of amniotic fluid of children diagnosed later in life with ASD and controls frequency-matched to cases on gender and year of birth. In this follow-up study, levels of the same chemokines were analyzed postnatally in dried blood spot samples from the same subjects utilizing the Danish Newborn Screening Biobank. Crude estimates showed decreased levels of RANTES. In the adjusted estimates, no differences were found in levels of the three examined chemokines in ASD cases compared to controls. Our findings may cautiously suggest an altered cell-mediated immunity during the early neonatal period in ASD. Further research is needed to examine the relationship between maternal/fetal and neonatal chemokine levels and their role in ASD.

U2 - 10.1016/j.cyto.2012.11.015

DO - 10.1016/j.cyto.2012.11.015

M3 - Journal article

C2 - 23267761

VL - 61

SP - 370

EP - 376

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 2

ER -

ID: 44583364

Department of Public Health