Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands

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Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Issue number18
Pages (from-to)5431-5433
Publication statusPublished - 15 Sep 2010

    Research areas

  • Cell Line, Hela Cells, Humans, Indoles, Ligands, Protein Binding, Pyrazines, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Structure-Activity Relationship
  • Former Faculty of Pharmaceutical Sciences

ID: 34207860