Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands
Research output: Contribution to journal › Journal article › Research › peer-review
Niels Krogsgaard-Larsen, Anders A. Jensen, Jan Kehler
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.
|Journal||Bioorganic & Medicinal Chemistry Letters|
|Publication status||Published - 15 Sep 2010|
- Cell Line, Hela Cells, Humans, Indoles, Ligands, Protein Binding, Pyrazines, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Structure-Activity Relationship
- The Faculty of Pharmaceutical Sciences