Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children
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Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children. / Stokholm, Lonny; Juhl, Mette; Lønfeldt, Nicole N; Mikkelsen, Susanne H; Obel, Carsten; Strandberg-Larsen, Katrine.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 97, No. 7, 2018, p. 880-889.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children
AU - Stokholm, Lonny
AU - Juhl, Mette
AU - Lønfeldt, Nicole N
AU - Mikkelsen, Susanne H
AU - Obel, Carsten
AU - Strandberg-Larsen, Katrine
N1 - © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age 7 (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.RESULTS: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.
AB - INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age 7 (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.RESULTS: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.
U2 - 10.1111/aogs.13344
DO - 10.1111/aogs.13344
M3 - Journal article
C2 - 29574678
VL - 97
SP - 880
EP - 889
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 7
ER -
ID: 194913313