Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

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Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation : A European Meta-Analysis. / Birks, Laura; Casas, Maribel; Garcia, Ana M.; Alexander, Jan; Barros, Henrique; Bergstrom, Anna; Bonde, Jens Peter; Burdorf, Alex; Costet, Nathalie; Danileviciute, Asta; Eggesbo, Merete; Fernandez, Mariana F.; Gonzalez-Galarzo, M. Carmen; Grazuleviciene, Regina; Hanke, Wojciech; Jaddoe, Vincent; Kogevinas, Manolis; Kull, Inger; Lertxundi, Aitana; Melaki, Vasiliki; Andersen, Anne-Marie Nybo; Olea, Nicols; Polanska, Kinga; Rusconi, Franca; Santa Marina, Loreto; Santos, Ana Cristina; Vrijkotte, Tanja; Zugna, Daniela; Nieuwenhuijsen, Mark; Cordier, Sylvaine; Vrijheid, Martine.

In: Environmental Health Perspectives, Vol. 124, No. 11, 11.2016, p. 1785-1793.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Birks, L, Casas, M, Garcia, AM, Alexander, J, Barros, H, Bergstrom, A, Bonde, JP, Burdorf, A, Costet, N, Danileviciute, A, Eggesbo, M, Fernandez, MF, Gonzalez-Galarzo, MC, Grazuleviciene, R, Hanke, W, Jaddoe, V, Kogevinas, M, Kull, I, Lertxundi, A, Melaki, V, Andersen, A-MN, Olea, N, Polanska, K, Rusconi, F, Santa Marina, L, Santos, AC, Vrijkotte, T, Zugna, D, Nieuwenhuijsen, M, Cordier, S & Vrijheid, M 2016, 'Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis', Environmental Health Perspectives, vol. 124, no. 11, pp. 1785-1793. https://doi.org/10.1289/EHP208

APA

Birks, L., Casas, M., Garcia, A. M., Alexander, J., Barros, H., Bergstrom, A., ... Vrijheid, M. (2016). Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environmental Health Perspectives, 124(11), 1785-1793. https://doi.org/10.1289/EHP208

Vancouver

Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergstrom A et al. Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environmental Health Perspectives. 2016 Nov;124(11):1785-1793. https://doi.org/10.1289/EHP208

Author

Birks, Laura ; Casas, Maribel ; Garcia, Ana M. ; Alexander, Jan ; Barros, Henrique ; Bergstrom, Anna ; Bonde, Jens Peter ; Burdorf, Alex ; Costet, Nathalie ; Danileviciute, Asta ; Eggesbo, Merete ; Fernandez, Mariana F. ; Gonzalez-Galarzo, M. Carmen ; Grazuleviciene, Regina ; Hanke, Wojciech ; Jaddoe, Vincent ; Kogevinas, Manolis ; Kull, Inger ; Lertxundi, Aitana ; Melaki, Vasiliki ; Andersen, Anne-Marie Nybo ; Olea, Nicols ; Polanska, Kinga ; Rusconi, Franca ; Santa Marina, Loreto ; Santos, Ana Cristina ; Vrijkotte, Tanja ; Zugna, Daniela ; Nieuwenhuijsen, Mark ; Cordier, Sylvaine ; Vrijheid, Martine. / Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation : A European Meta-Analysis. In: Environmental Health Perspectives. 2016 ; Vol. 124, No. 11. pp. 1785-1793.

Bibtex

@article{2955cf3f555d48809069ab2b5b00bc68,
title = "Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis",
abstract = "Background: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.Objectives: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.Methods: Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates.Results: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95{\%} CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95{\%} CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.Conclusion: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.",
author = "Laura Birks and Maribel Casas and Garcia, {Ana M.} and Jan Alexander and Henrique Barros and Anna Bergstrom and Bonde, {Jens Peter} and Alex Burdorf and Nathalie Costet and Asta Danileviciute and Merete Eggesbo and Fernandez, {Mariana F.} and Gonzalez-Galarzo, {M. Carmen} and Regina Grazuleviciene and Wojciech Hanke and Vincent Jaddoe and Manolis Kogevinas and Inger Kull and Aitana Lertxundi and Vasiliki Melaki and Andersen, {Anne-Marie Nybo} and Nicols Olea and Kinga Polanska and Franca Rusconi and {Santa Marina}, Loreto and Santos, {Ana Cristina} and Tanja Vrijkotte and Daniela Zugna and Mark Nieuwenhuijsen and Sylvaine Cordier and Martine Vrijheid",
year = "2016",
month = "11",
doi = "10.1289/EHP208",
language = "English",
volume = "124",
pages = "1785--1793",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "National Institute of Environmental Health Sciences",
number = "11",

}

RIS

TY - JOUR

T1 - Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation

T2 - A European Meta-Analysis

AU - Birks, Laura

AU - Casas, Maribel

AU - Garcia, Ana M.

AU - Alexander, Jan

AU - Barros, Henrique

AU - Bergstrom, Anna

AU - Bonde, Jens Peter

AU - Burdorf, Alex

AU - Costet, Nathalie

AU - Danileviciute, Asta

AU - Eggesbo, Merete

AU - Fernandez, Mariana F.

AU - Gonzalez-Galarzo, M. Carmen

AU - Grazuleviciene, Regina

AU - Hanke, Wojciech

AU - Jaddoe, Vincent

AU - Kogevinas, Manolis

AU - Kull, Inger

AU - Lertxundi, Aitana

AU - Melaki, Vasiliki

AU - Andersen, Anne-Marie Nybo

AU - Olea, Nicols

AU - Polanska, Kinga

AU - Rusconi, Franca

AU - Santa Marina, Loreto

AU - Santos, Ana Cristina

AU - Vrijkotte, Tanja

AU - Zugna, Daniela

AU - Nieuwenhuijsen, Mark

AU - Cordier, Sylvaine

AU - Vrijheid, Martine

PY - 2016/11

Y1 - 2016/11

N2 - Background: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.Objectives: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.Methods: Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates.Results: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.Conclusion: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.

AB - Background: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.Objectives: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.Methods: Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates.Results: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.Conclusion: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.

U2 - 10.1289/EHP208

DO - 10.1289/EHP208

M3 - Journal article

C2 - 27152464

VL - 124

SP - 1785

EP - 1793

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 11

ER -

ID: 169158593