Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface

Research output: Working paperPreprintResearch

Standard

Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface. / Meneghetti, Marcello; Kaur, Jaspreet; Sui, Kunyang; Sørensen, Roar Jakob Fleng ; Berg, Rune W.; Markos, Christos.

2022. p. 1-19.

Research output: Working paperPreprintResearch

Harvard

Meneghetti, M, Kaur, J, Sui, K, Sørensen, RJF, Berg, RW & Markos, C 2022 'Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface' pp. 1-19. https://doi.org/10.1101/2022.05.23.493057

APA

Meneghetti, M., Kaur, J., Sui, K., Sørensen, R. J. F., Berg, R. W., & Markos, C. (2022). Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface. (pp. 1-19). bioRxiv https://doi.org/10.1101/2022.05.23.493057

Vancouver

Meneghetti M, Kaur J, Sui K, Sørensen RJF, Berg RW, Markos C. Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface. 2022 May 23, p. 1-19. https://doi.org/10.1101/2022.05.23.493057

Author

Meneghetti, Marcello ; Kaur, Jaspreet ; Sui, Kunyang ; Sørensen, Roar Jakob Fleng ; Berg, Rune W. ; Markos, Christos. / Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface. 2022. pp. 1-19 (bioRxiv).

Bibtex

@techreport{4294b02530c34706be2e8f1a18897e64,
title = "Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface",
abstract = "Controlling neuronal activity with high spatial resolution using multifunctional and minimally invasive neural interfaces constitutes an important step towards developments in neuroscience and novel treatments for brain diseases. While infrared neuromodulation is an emerging technology for controlling the neuronal circuitry, it lacks soft implantable monolithic interfaces capable of simultaneously delivering light and recording electrical signals from the brain while being mechanically brain-compatible. Here, we have developed a soft fibre-based device based on high-performance thermoplastics which are >100-fold softer than silica glass. The presented fibre-implant is capable of safely neuromodulating the brain activity in localized cortical domains by delivering infrared laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo in adult rats while immunohistochemical analysis of the tissue indicated limited microglia and monocytes response introduced by the fibre and the infrared pulses. We expect our devices to further enhance infrared neuromodulation as a versatile approach for fundamental research and clinically translatable therapeutic interventions.",
keywords = "Faculty of Health and Medical Sciences",
author = "Marcello Meneghetti and Jaspreet Kaur and Kunyang Sui and S{\o}rensen, {Roar Jakob Fleng} and Berg, {Rune W.} and Christos Markos",
year = "2022",
month = may,
day = "23",
doi = "10.1101/2022.05.23.493057",
language = "English",
series = "bioRxiv",
pages = "1--19",
type = "WorkingPaper",

}

RIS

TY - UNPB

T1 - Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface

AU - Meneghetti, Marcello

AU - Kaur, Jaspreet

AU - Sui, Kunyang

AU - Sørensen, Roar Jakob Fleng

AU - Berg, Rune W.

AU - Markos, Christos

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Controlling neuronal activity with high spatial resolution using multifunctional and minimally invasive neural interfaces constitutes an important step towards developments in neuroscience and novel treatments for brain diseases. While infrared neuromodulation is an emerging technology for controlling the neuronal circuitry, it lacks soft implantable monolithic interfaces capable of simultaneously delivering light and recording electrical signals from the brain while being mechanically brain-compatible. Here, we have developed a soft fibre-based device based on high-performance thermoplastics which are >100-fold softer than silica glass. The presented fibre-implant is capable of safely neuromodulating the brain activity in localized cortical domains by delivering infrared laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo in adult rats while immunohistochemical analysis of the tissue indicated limited microglia and monocytes response introduced by the fibre and the infrared pulses. We expect our devices to further enhance infrared neuromodulation as a versatile approach for fundamental research and clinically translatable therapeutic interventions.

AB - Controlling neuronal activity with high spatial resolution using multifunctional and minimally invasive neural interfaces constitutes an important step towards developments in neuroscience and novel treatments for brain diseases. While infrared neuromodulation is an emerging technology for controlling the neuronal circuitry, it lacks soft implantable monolithic interfaces capable of simultaneously delivering light and recording electrical signals from the brain while being mechanically brain-compatible. Here, we have developed a soft fibre-based device based on high-performance thermoplastics which are >100-fold softer than silica glass. The presented fibre-implant is capable of safely neuromodulating the brain activity in localized cortical domains by delivering infrared laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo in adult rats while immunohistochemical analysis of the tissue indicated limited microglia and monocytes response introduced by the fibre and the infrared pulses. We expect our devices to further enhance infrared neuromodulation as a versatile approach for fundamental research and clinically translatable therapeutic interventions.

KW - Faculty of Health and Medical Sciences

UR - https://www.biorxiv.org/content/10.1101/2022.05.23.493057v1

U2 - 10.1101/2022.05.23.493057

DO - 10.1101/2022.05.23.493057

M3 - Preprint

T3 - bioRxiv

SP - 1

EP - 19

BT - Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface

ER -

ID: 308823295