Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Osteon cross-sectional size in the iliac crest : variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. / Broulik, P; Kragstrup, J; Mosekilde, L; Melsen, F.

In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, Vol. 90, No. 5, 09.1982, p. 339-44.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Broulik, P, Kragstrup, J, Mosekilde, L & Melsen, F 1982, 'Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia', Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, vol. 90, no. 5, pp. 339-44.

APA

Broulik, P., Kragstrup, J., Mosekilde, L., & Melsen, F. (1982). Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 90(5), 339-44.

Vancouver

Broulik P, Kragstrup J, Mosekilde L, Melsen F. Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology. 1982 Sep;90(5):339-44.

Author

Broulik, P ; Kragstrup, J ; Mosekilde, L ; Melsen, F. / Osteon cross-sectional size in the iliac crest : variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology. 1982 ; Vol. 90, No. 5. pp. 339-44.

Bibtex

@article{6ef880c61ba447d0ab9cc52915838682,
title = "Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia",
abstract = "Cross-sectional osteon size was measured in undecalcified stained sections of iliac crest bone specimens from normal individuals (n = 68) and from patients with spinal osteoporosis (n = 27), primary hyperparathyroidism (n = 23), epilepsia (receiving chronic anti-convulsant therapy) (n = 11), acromegaly (n = 18), and hypothyroidism (n = 12). In each individual the shortest osteon diameter (D) and the corresponding Haversian canal diameter (d) were measured in a minimum of 20 completed secondary osteons by means of a micrometer eyepiece. Among normal males the areas of bone resorbed and formed increased with age (p less than 0.01), owing to an increase in the thickness of bone resorbed (p less than 0.01) and an unchanged thickness of bone formed. Among the females, both the areas of bone resorbed and formed decreased with age (p less than 0.05), owing to a reduction in the thickness of bone resorbed (p less than 0.05) as well as formed (p less than 0.001). Resorbed and formed areas were reduced in the epileptic (p less than 0.01) and acromegalic (p less than 0.01) groups but increased in the hypothyroid group (p less than 0.01) compared to sex- and age-matched controls. Neither the osteoporotic nor the hyperparathyroid group showed any alterations in osteon size. The Haversian canal diameter was slightly increased in the epileptic group but normal in the other patient groups. The observed changes reflect variations in the amount of work performed by osteoclasts and osteoblasts during bone remodelling and may be explained by variations in cellular activity and bone turn-over rates.",
keywords = "Acromegaly/pathology, Adult, Aged, Bone Resorption, Epilepsy/pathology, Female, Haversian System/anatomy & histology, Humans, Hyperparathyroidism/pathology, Hypothyroidism/pathology, Ilium/anatomy & histology, Male, Middle Aged, Ossification, Heterotopic, Osteoblasts/cytology, Osteoclasts/cytology, Osteoporosis/pathology",
author = "P Broulik and J Kragstrup and L Mosekilde and F Melsen",
year = "1982",
month = sep,
language = "English",
volume = "90",
pages = "339--44",
journal = "Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology",
issn = "0108-0164",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Osteon cross-sectional size in the iliac crest

T2 - variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia

AU - Broulik, P

AU - Kragstrup, J

AU - Mosekilde, L

AU - Melsen, F

PY - 1982/9

Y1 - 1982/9

N2 - Cross-sectional osteon size was measured in undecalcified stained sections of iliac crest bone specimens from normal individuals (n = 68) and from patients with spinal osteoporosis (n = 27), primary hyperparathyroidism (n = 23), epilepsia (receiving chronic anti-convulsant therapy) (n = 11), acromegaly (n = 18), and hypothyroidism (n = 12). In each individual the shortest osteon diameter (D) and the corresponding Haversian canal diameter (d) were measured in a minimum of 20 completed secondary osteons by means of a micrometer eyepiece. Among normal males the areas of bone resorbed and formed increased with age (p less than 0.01), owing to an increase in the thickness of bone resorbed (p less than 0.01) and an unchanged thickness of bone formed. Among the females, both the areas of bone resorbed and formed decreased with age (p less than 0.05), owing to a reduction in the thickness of bone resorbed (p less than 0.05) as well as formed (p less than 0.001). Resorbed and formed areas were reduced in the epileptic (p less than 0.01) and acromegalic (p less than 0.01) groups but increased in the hypothyroid group (p less than 0.01) compared to sex- and age-matched controls. Neither the osteoporotic nor the hyperparathyroid group showed any alterations in osteon size. The Haversian canal diameter was slightly increased in the epileptic group but normal in the other patient groups. The observed changes reflect variations in the amount of work performed by osteoclasts and osteoblasts during bone remodelling and may be explained by variations in cellular activity and bone turn-over rates.

AB - Cross-sectional osteon size was measured in undecalcified stained sections of iliac crest bone specimens from normal individuals (n = 68) and from patients with spinal osteoporosis (n = 27), primary hyperparathyroidism (n = 23), epilepsia (receiving chronic anti-convulsant therapy) (n = 11), acromegaly (n = 18), and hypothyroidism (n = 12). In each individual the shortest osteon diameter (D) and the corresponding Haversian canal diameter (d) were measured in a minimum of 20 completed secondary osteons by means of a micrometer eyepiece. Among normal males the areas of bone resorbed and formed increased with age (p less than 0.01), owing to an increase in the thickness of bone resorbed (p less than 0.01) and an unchanged thickness of bone formed. Among the females, both the areas of bone resorbed and formed decreased with age (p less than 0.05), owing to a reduction in the thickness of bone resorbed (p less than 0.05) as well as formed (p less than 0.001). Resorbed and formed areas were reduced in the epileptic (p less than 0.01) and acromegalic (p less than 0.01) groups but increased in the hypothyroid group (p less than 0.01) compared to sex- and age-matched controls. Neither the osteoporotic nor the hyperparathyroid group showed any alterations in osteon size. The Haversian canal diameter was slightly increased in the epileptic group but normal in the other patient groups. The observed changes reflect variations in the amount of work performed by osteoclasts and osteoblasts during bone remodelling and may be explained by variations in cellular activity and bone turn-over rates.

KW - Acromegaly/pathology

KW - Adult

KW - Aged

KW - Bone Resorption

KW - Epilepsy/pathology

KW - Female

KW - Haversian System/anatomy & histology

KW - Humans

KW - Hyperparathyroidism/pathology

KW - Hypothyroidism/pathology

KW - Ilium/anatomy & histology

KW - Male

KW - Middle Aged

KW - Ossification, Heterotopic

KW - Osteoblasts/cytology

KW - Osteoclasts/cytology

KW - Osteoporosis/pathology

M3 - Journal article

C2 - 6816007

VL - 90

SP - 339

EP - 344

JO - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology

JF - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology

SN - 0108-0164

IS - 5

ER -

ID: 324195822