Oxidative stress generated damage to DNA by gastrointestinal exposure to insoluble particles
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Oxidative stress generated damage to DNA by gastrointestinal exposure to insoluble particles. / Møller, Peter; Folkmann, J K; Danielsen, P H; Jantzen, K; Loft, S.
In: Current Molecular Medicine, Vol. 12, No. 6, 2012, p. 732-45.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oxidative stress generated damage to DNA by gastrointestinal exposure to insoluble particles
AU - Møller, Peter
AU - Folkmann, J K
AU - Danielsen, P H
AU - Jantzen, K
AU - Loft, S
PY - 2012
Y1 - 2012
N2 - There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposure to single-walled carbon nanotubes (SWCNT), fullerenes C60, carbon black, titanium dioxide and diesel exhaust particles generates oxidized DNA base lesions in organs such as the bone marrow, liver and lung. Oral exposure to nanosized carbon black has also been associated with increased level of lipid peroxidation derived exocyclic DNA adducts in the liver, suggesting multiple pathways of oxidative stress for particle-generated damage to DNA. At equal dose, diesel exhaust particles (SRM2975) generated larger levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine in rat liver than carbon black (Printex 90) did, whereas exposure to fullerenes C60 and SWCNT was the least potent. This ranking of samples was also observed for oxidatively damaged DNA in cultured cells. The extent of translocation from the gut is largely unresolved. However, there is evidence indicating that gastrointestinal exposure to particulate matter is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.
AB - There is growing concern that gastrointestinal exposure to particles is associated with increased risk of toxicity to internal organs and carcinogenicity. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Observations from animal models indicate that gastrointestinal exposure to single-walled carbon nanotubes (SWCNT), fullerenes C60, carbon black, titanium dioxide and diesel exhaust particles generates oxidized DNA base lesions in organs such as the bone marrow, liver and lung. Oral exposure to nanosized carbon black has also been associated with increased level of lipid peroxidation derived exocyclic DNA adducts in the liver, suggesting multiple pathways of oxidative stress for particle-generated damage to DNA. At equal dose, diesel exhaust particles (SRM2975) generated larger levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine in rat liver than carbon black (Printex 90) did, whereas exposure to fullerenes C60 and SWCNT was the least potent. This ranking of samples was also observed for oxidatively damaged DNA in cultured cells. The extent of translocation from the gut is largely unresolved. However, there is evidence indicating that gastrointestinal exposure to particulate matter is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.
U2 - 10.2174/156652412800792624
DO - 10.2174/156652412800792624
M3 - Journal article
C2 - 22292440
VL - 12
SP - 732
EP - 745
JO - Current Molecular Medicine
JF - Current Molecular Medicine
SN - 1566-5240
IS - 6
ER -
ID: 38494639