P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

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P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. / Waaijer, Mariëtte E C; Gunn, David A; Adams, Peter D; Pawlikowski, Jeff S; Griffiths, Christopher E M; van Heemst, Diana; Slagboom, P Eline; Westendorp, Rudi G. J.; Maier, Andrea B.

In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Vol. 71, No. 8, 08.2016, p. 1022-1028.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Waaijer, MEC, Gunn, DA, Adams, PD, Pawlikowski, JS, Griffiths, CEM, van Heemst, D, Slagboom, PE, Westendorp, RGJ & Maier, AB 2016, 'P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol. 71, no. 8, pp. 1022-1028. https://doi.org/10.1093/gerona/glv114

APA

Waaijer, M. E. C., Gunn, D. A., Adams, P. D., Pawlikowski, J. S., Griffiths, C. E. M., van Heemst, D., Slagboom, P. E., Westendorp, R. G. J., & Maier, A. B. (2016). P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 71(8), 1022-1028. https://doi.org/10.1093/gerona/glv114

Vancouver

Waaijer MEC, Gunn DA, Adams PD, Pawlikowski JS, Griffiths CEM, van Heemst D et al. P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 2016 Aug;71(8):1022-1028. https://doi.org/10.1093/gerona/glv114

Author

Waaijer, Mariëtte E C ; Gunn, David A ; Adams, Peter D ; Pawlikowski, Jeff S ; Griffiths, Christopher E M ; van Heemst, Diana ; Slagboom, P Eline ; Westendorp, Rudi G. J. ; Maier, Andrea B. / P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 2016 ; Vol. 71, No. 8. pp. 1022-1028.

Bibtex

@article{bb3b67cc85a24a68b9d6584ad0ceca0c,
title = "P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age",
abstract = "Senescent cells are more prevalent in aged human skin compared to young, but evidence that senescent cells are linked to other biomarkers of aging is scarce. We counted cells positive for the tumor suppressor and senescence associated protein p16INK4a in sun-protected upper-inner arm skin biopsies from 178 participants (aged 45-81 years) of the Leiden Longevity Study. Local elastic fiber morphology, facial wrinkles, and perceived facial age were compared to tertiles of p16INK4a counts, while adjusting for chronological age and other potential confounders. The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic characteristics, such as longer and a greater number of elastic fibers. The p16INK4a positive epidermal cells (identified as primarily melanocytes) were also significantly associated with more facial wrinkles and a higher perceived age. Participants in the lowest tertile of epidermal p16INK4a counts looked 3 years younger than those in the highest tertile, independently of chronological age and elastic fiber morphology. In conclusion, p16INK4a positive cell numbers in sun-protected human arm skin are indicative of both local elastic fiber morphology and the extent of aging visible in the face.",
author = "Waaijer, {Mari{\"e}tte E C} and Gunn, {David A} and Adams, {Peter D} and Pawlikowski, {Jeff S} and Griffiths, {Christopher E M} and {van Heemst}, Diana and Slagboom, {P Eline} and Westendorp, {Rudi G. J.} and Maier, {Andrea B}",
note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2016",
month = aug,
doi = "10.1093/gerona/glv114",
language = "English",
volume = "71",
pages = "1022--1028",
journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

AU - Waaijer, Mariëtte E C

AU - Gunn, David A

AU - Adams, Peter D

AU - Pawlikowski, Jeff S

AU - Griffiths, Christopher E M

AU - van Heemst, Diana

AU - Slagboom, P Eline

AU - Westendorp, Rudi G. J.

AU - Maier, Andrea B

N1 - © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2016/8

Y1 - 2016/8

N2 - Senescent cells are more prevalent in aged human skin compared to young, but evidence that senescent cells are linked to other biomarkers of aging is scarce. We counted cells positive for the tumor suppressor and senescence associated protein p16INK4a in sun-protected upper-inner arm skin biopsies from 178 participants (aged 45-81 years) of the Leiden Longevity Study. Local elastic fiber morphology, facial wrinkles, and perceived facial age were compared to tertiles of p16INK4a counts, while adjusting for chronological age and other potential confounders. The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic characteristics, such as longer and a greater number of elastic fibers. The p16INK4a positive epidermal cells (identified as primarily melanocytes) were also significantly associated with more facial wrinkles and a higher perceived age. Participants in the lowest tertile of epidermal p16INK4a counts looked 3 years younger than those in the highest tertile, independently of chronological age and elastic fiber morphology. In conclusion, p16INK4a positive cell numbers in sun-protected human arm skin are indicative of both local elastic fiber morphology and the extent of aging visible in the face.

AB - Senescent cells are more prevalent in aged human skin compared to young, but evidence that senescent cells are linked to other biomarkers of aging is scarce. We counted cells positive for the tumor suppressor and senescence associated protein p16INK4a in sun-protected upper-inner arm skin biopsies from 178 participants (aged 45-81 years) of the Leiden Longevity Study. Local elastic fiber morphology, facial wrinkles, and perceived facial age were compared to tertiles of p16INK4a counts, while adjusting for chronological age and other potential confounders. The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic characteristics, such as longer and a greater number of elastic fibers. The p16INK4a positive epidermal cells (identified as primarily melanocytes) were also significantly associated with more facial wrinkles and a higher perceived age. Participants in the lowest tertile of epidermal p16INK4a counts looked 3 years younger than those in the highest tertile, independently of chronological age and elastic fiber morphology. In conclusion, p16INK4a positive cell numbers in sun-protected human arm skin are indicative of both local elastic fiber morphology and the extent of aging visible in the face.

U2 - 10.1093/gerona/glv114

DO - 10.1093/gerona/glv114

M3 - Journal article

C2 - 26286607

VL - 71

SP - 1022

EP - 1028

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

IS - 8

ER -

ID: 146207131