Penta is associated with an increased female-male mortality ratio: cohort study from Bangladesh

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Penta is associated with an increased female-male mortality ratio : cohort study from Bangladesh. / Hanifi, Syed Manzoor Ahmed; Biering-Sørensen, Sofie; Jensen, Aksel Karl Georg; Aaby, Peter; Bhuiya, Abbas.

In: Human Vaccines and Immunotherapeutics, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hanifi, SMA, Biering-Sørensen, S, Jensen, AKG, Aaby, P & Bhuiya, A 2020, 'Penta is associated with an increased female-male mortality ratio: cohort study from Bangladesh', Human Vaccines and Immunotherapeutics. https://doi.org/10.1080/21645515.2020.1763084

APA

Hanifi, S. M. A., Biering-Sørensen, S., Jensen, A. K. G., Aaby, P., & Bhuiya, A. (Accepted/In press). Penta is associated with an increased female-male mortality ratio: cohort study from Bangladesh. Human Vaccines and Immunotherapeutics. https://doi.org/10.1080/21645515.2020.1763084

Vancouver

Hanifi SMA, Biering-Sørensen S, Jensen AKG, Aaby P, Bhuiya A. Penta is associated with an increased female-male mortality ratio: cohort study from Bangladesh. Human Vaccines and Immunotherapeutics. 2020. https://doi.org/10.1080/21645515.2020.1763084

Author

Hanifi, Syed Manzoor Ahmed ; Biering-Sørensen, Sofie ; Jensen, Aksel Karl Georg ; Aaby, Peter ; Bhuiya, Abbas. / Penta is associated with an increased female-male mortality ratio : cohort study from Bangladesh. In: Human Vaccines and Immunotherapeutics. 2020.

Bibtex

@article{5c63fa27c20d448ea4d8f90b66b69fac,
title = "Penta is associated with an increased female-male mortality ratio: cohort study from Bangladesh",
abstract = "Diphtheria-tetanus-pertussis (DTP) vaccine may be associated with excess female deaths. There are few studies of possible nonspecific effects of the DTP-containing vaccine Penta (DTP-hepatitis B-Haemophilus influenzae type b). We therefore investigated whether Penta vaccinations were associated with excess female deaths in rural Bangladesh. Between June 29, 2011 and April 20, 2016, we examined the mortality rates of 7644 children followed between 6 weeks and 9 months of age. We analyzed mortality using crude mortality rate ratio (MRR) and age-adjusted MRR (aMRR) from a Cox proportional hazards model. Mortality was analyzed according to sex, number of doses of Penta, and the order in which BCG and Penta were administered. During follow-up, 43 children died. For children who were only BCG vaccinated (BCG-only), the adjusted F/M MRR was 0.47 (0.09–2.48). However, among children who had Penta as their most recent vaccination, the adjusted F/M MRR was 9.91 (1.16–84.44). Hence, the adjusted F/M MRR differed significantly for BCG-only and for Penta as the most recent administered vaccination. Although the mortality rate was low in rural Bangladesh, there was a marked difference between adjusted F/M MRR’s for children vaccinated with BCG-only compared with children where Penta was the most recent administered vaccination. Although usually ascribed to differential treatment and access to care, DTP-containing vaccines may be part of the explanation for the excessive female mortality reported in some regions.",
keywords = "BCG, mortality, Nonspecific/heterologous effects of vaccines, penta, sex-differential effects",
author = "Hanifi, {Syed Manzoor Ahmed} and Sofie Biering-S{\o}rensen and Jensen, {Aksel Karl Georg} and Peter Aaby and Abbas Bhuiya",
year = "2020",
doi = "10.1080/21645515.2020.1763084",
language = "English",
journal = "Human Vaccines & Immunotherapeutics",
issn = "2164-5515",
publisher = "Taylor & Francis",

}

RIS

TY - JOUR

T1 - Penta is associated with an increased female-male mortality ratio

T2 - cohort study from Bangladesh

AU - Hanifi, Syed Manzoor Ahmed

AU - Biering-Sørensen, Sofie

AU - Jensen, Aksel Karl Georg

AU - Aaby, Peter

AU - Bhuiya, Abbas

PY - 2020

Y1 - 2020

N2 - Diphtheria-tetanus-pertussis (DTP) vaccine may be associated with excess female deaths. There are few studies of possible nonspecific effects of the DTP-containing vaccine Penta (DTP-hepatitis B-Haemophilus influenzae type b). We therefore investigated whether Penta vaccinations were associated with excess female deaths in rural Bangladesh. Between June 29, 2011 and April 20, 2016, we examined the mortality rates of 7644 children followed between 6 weeks and 9 months of age. We analyzed mortality using crude mortality rate ratio (MRR) and age-adjusted MRR (aMRR) from a Cox proportional hazards model. Mortality was analyzed according to sex, number of doses of Penta, and the order in which BCG and Penta were administered. During follow-up, 43 children died. For children who were only BCG vaccinated (BCG-only), the adjusted F/M MRR was 0.47 (0.09–2.48). However, among children who had Penta as their most recent vaccination, the adjusted F/M MRR was 9.91 (1.16–84.44). Hence, the adjusted F/M MRR differed significantly for BCG-only and for Penta as the most recent administered vaccination. Although the mortality rate was low in rural Bangladesh, there was a marked difference between adjusted F/M MRR’s for children vaccinated with BCG-only compared with children where Penta was the most recent administered vaccination. Although usually ascribed to differential treatment and access to care, DTP-containing vaccines may be part of the explanation for the excessive female mortality reported in some regions.

AB - Diphtheria-tetanus-pertussis (DTP) vaccine may be associated with excess female deaths. There are few studies of possible nonspecific effects of the DTP-containing vaccine Penta (DTP-hepatitis B-Haemophilus influenzae type b). We therefore investigated whether Penta vaccinations were associated with excess female deaths in rural Bangladesh. Between June 29, 2011 and April 20, 2016, we examined the mortality rates of 7644 children followed between 6 weeks and 9 months of age. We analyzed mortality using crude mortality rate ratio (MRR) and age-adjusted MRR (aMRR) from a Cox proportional hazards model. Mortality was analyzed according to sex, number of doses of Penta, and the order in which BCG and Penta were administered. During follow-up, 43 children died. For children who were only BCG vaccinated (BCG-only), the adjusted F/M MRR was 0.47 (0.09–2.48). However, among children who had Penta as their most recent vaccination, the adjusted F/M MRR was 9.91 (1.16–84.44). Hence, the adjusted F/M MRR differed significantly for BCG-only and for Penta as the most recent administered vaccination. Although the mortality rate was low in rural Bangladesh, there was a marked difference between adjusted F/M MRR’s for children vaccinated with BCG-only compared with children where Penta was the most recent administered vaccination. Although usually ascribed to differential treatment and access to care, DTP-containing vaccines may be part of the explanation for the excessive female mortality reported in some regions.

KW - BCG

KW - mortality

KW - Nonspecific/heterologous effects of vaccines

KW - penta

KW - sex-differential effects

U2 - 10.1080/21645515.2020.1763084

DO - 10.1080/21645515.2020.1763084

M3 - Journal article

C2 - 32573310

AN - SCOPUS:85087383195

JO - Human Vaccines & Immunotherapeutics

JF - Human Vaccines & Immunotherapeutics

SN - 2164-5515

ER -

ID: 245077372