TY - JOUR

T1 - Physical Activity and Subsequent Change in Body Weight, Composition and Shape

T2 - Effect Modification by Familial Overweight

AU - Specht, Ina Olmer

AU - Heitmann, Berit Lilienthal

AU - Larsen, Sofus Christian

PY - 2022

Y1 - 2022

N2 - BackgroundPhysical activity (PA) has been shown to attenuate the genetic risk of obesity as measured using polygenic risk scores. However, familial obesity history might be an easier predictor. We examined associations between PA and subsequent changes in BMI, body fat percentage (BF%) and waist circumference (WC) among participants with and without adiposity and a familial overweight. MethodsIn total, 1971 participants from the Danish MONICA cohort were included. Mean differences for 6-year changes in BMI, BF% and WC across PA levels were estimated. Association between walking and biking and subsequent change in adiposity were analysed. Effect modification by familial obesity was assessed by adding product terms to the models. ResultsWe observed weak associations between leisure PA level and changes in WC [participants with low PA: 3.4 cm (95%CI: 2.8;4.0), participants with high PA: 2.4 cm (95%CI: 1.8;3.0)], with no evidence of effect modification by familial obesity. We found effect modification in analyses on walking and biking in relation to changes in BMI (P-interaction

AB - BackgroundPhysical activity (PA) has been shown to attenuate the genetic risk of obesity as measured using polygenic risk scores. However, familial obesity history might be an easier predictor. We examined associations between PA and subsequent changes in BMI, body fat percentage (BF%) and waist circumference (WC) among participants with and without adiposity and a familial overweight. MethodsIn total, 1971 participants from the Danish MONICA cohort were included. Mean differences for 6-year changes in BMI, BF% and WC across PA levels were estimated. Association between walking and biking and subsequent change in adiposity were analysed. Effect modification by familial obesity was assessed by adding product terms to the models. ResultsWe observed weak associations between leisure PA level and changes in WC [participants with low PA: 3.4 cm (95%CI: 2.8;4.0), participants with high PA: 2.4 cm (95%CI: 1.8;3.0)], with no evidence of effect modification by familial obesity. We found effect modification in analyses on walking and biking in relation to changes in BMI (P-interaction

KW - physical activity

KW - adiposity

KW - obesity

KW - PAL

KW - genetic

KW - MASS INDEX

KW - WAIST CIRCUMFERENCE

KW - OBESITY

KW - TIME

KW - MEN

KW - FAT

U2 - 10.3389/fendo.2022.787827

DO - 10.3389/fendo.2022.787827

M3 - Journal article

C2 - 35242107

VL - 13

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 787827

ER -