Physical deterioration and adaptive recovery in physically inactive breast cancer patients during adjuvant chemotherapy: a randomised controlled trial
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Physical deterioration and adaptive recovery in physically inactive breast cancer patients during adjuvant chemotherapy : a randomised controlled trial. / Møller, Tom; Andersen, Christina; Lillelund, Christian; Bloomquist, Kira; Christensen, Karl Bang; Ejlertsen, Bent; Tuxen, Malgorzata; Oturai, Peter; Breitenstein, Ulla; Kolind, Cecilie; Travis, Pernille; Bjerg, Tina; Rørth, Mikael; Adamsen, Lis.
In: Scientific Reports, Vol. 10, No. 1, 9710, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Physical deterioration and adaptive recovery in physically inactive breast cancer patients during adjuvant chemotherapy
T2 - a randomised controlled trial
AU - Møller, Tom
AU - Andersen, Christina
AU - Lillelund, Christian
AU - Bloomquist, Kira
AU - Christensen, Karl Bang
AU - Ejlertsen, Bent
AU - Tuxen, Malgorzata
AU - Oturai, Peter
AU - Breitenstein, Ulla
AU - Kolind, Cecilie
AU - Travis, Pernille
AU - Bjerg, Tina
AU - Rørth, Mikael
AU - Adamsen, Lis
PY - 2020
Y1 - 2020
N2 - Cardiorespiratory fitness is an independent risk factor for cardiovascular disease and shortened life expectancy in breast cancer survivors. This randomised controlled trial (n=153) was designed for patients with a physically inactive lifestyle prediagnosis and concurrently referred to adjuvant chemotherapy. We compared two 12-week exercise interventions aimed at physiological and patient-reported outcomes (cardiorespiratory fitness, muscle strength, metabolic markers, physical activity, pain, fatigue), including a 39-week follow-up. A supervised hospital-based moderate to high intensity group exercise intervention was compared to an instructed home-based individual pedometer intervention. The two 12-week interventions included oncologists' recommendations and systematic health counselling. Outcomes were measured at baseline and week 6, 12 and 39. Primary outcome cardiorespiratory fitness declined significantly during chemotherapy and was restored in both interventions at follow-up. The interventions effectively engaged breast cancer patients in sustaining physical activities during and following adjuvant treatment. A composite metabolic score improved significantly. Positive cardiorespiratory fitness responders had improved clinical effects on fatigue, pain and dyspnoea versus negative responders. We conclude that a loss of cardiorespiratory fitness among physically inactive breast cancer patients may be restored by early initiated interventions and by adapting to physical activity recommendations, leading to a decreased cardiovascular risk profile in breast cancer survivors.
AB - Cardiorespiratory fitness is an independent risk factor for cardiovascular disease and shortened life expectancy in breast cancer survivors. This randomised controlled trial (n=153) was designed for patients with a physically inactive lifestyle prediagnosis and concurrently referred to adjuvant chemotherapy. We compared two 12-week exercise interventions aimed at physiological and patient-reported outcomes (cardiorespiratory fitness, muscle strength, metabolic markers, physical activity, pain, fatigue), including a 39-week follow-up. A supervised hospital-based moderate to high intensity group exercise intervention was compared to an instructed home-based individual pedometer intervention. The two 12-week interventions included oncologists' recommendations and systematic health counselling. Outcomes were measured at baseline and week 6, 12 and 39. Primary outcome cardiorespiratory fitness declined significantly during chemotherapy and was restored in both interventions at follow-up. The interventions effectively engaged breast cancer patients in sustaining physical activities during and following adjuvant treatment. A composite metabolic score improved significantly. Positive cardiorespiratory fitness responders had improved clinical effects on fatigue, pain and dyspnoea versus negative responders. We conclude that a loss of cardiorespiratory fitness among physically inactive breast cancer patients may be restored by early initiated interventions and by adapting to physical activity recommendations, leading to a decreased cardiovascular risk profile in breast cancer survivors.
KW - METABOLIC SYNDROME RISK
KW - CARDIORESPIRATORY FITNESS
KW - WEIGHT-GAIN
KW - FOLLOW-UP
KW - EXERCISE
KW - HEALTH
KW - SURVIVORS
KW - STRENGTH
KW - OBESITY
KW - WOMEN
U2 - 10.1038/s41598-020-66513-9
DO - 10.1038/s41598-020-66513-9
M3 - Journal article
C2 - 32546796
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 9710
ER -
ID: 247980814