Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study
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Precursors of age-related macular degeneration : associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study. / Munch, Inger Christine; Toft, Ulla; Linneberg, Allan; Larsen, Michael.
In: Acta Ophthalmologica, Vol. 94, No. 7, 11.2016, p. 657-662.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Precursors of age-related macular degeneration
T2 - associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study
AU - Munch, Inger Christine
AU - Toft, Ulla
AU - Linneberg, Allan
AU - Larsen, Michael
N1 - © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
PY - 2016/11
Y1 - 2016/11
N2 - PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.
AB - PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.
KW - Adult
KW - Complement Factor H
KW - Cross-Sectional Studies
KW - Diet
KW - Female
KW - Humans
KW - Macular Degeneration
KW - Male
KW - Middle Aged
KW - Polymorphism, Single Nucleotide
KW - Proteins
KW - Retinal Drusen
KW - Risk Factors
KW - Visual Acuity
KW - Vitamin A
KW - Vitamins
KW - Journal Article
KW - Randomized Controlled Trial
U2 - 10.1111/aos.13198
DO - 10.1111/aos.13198
M3 - Journal article
C2 - 27502478
VL - 94
SP - 657
EP - 662
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 7
ER -
ID: 173095092