Preeclampsia and scleroderma: a prospective nationwide analysis
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Preeclampsia and scleroderma : a prospective nationwide analysis. / Kamper-Jørgensen, Mads; Gammill, Hilary S; Lee Nelson, J.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 97, No. 5, 2018, p. 587-590.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Preeclampsia and scleroderma
T2 - a prospective nationwide analysis
AU - Kamper-Jørgensen, Mads
AU - Gammill, Hilary S
AU - Lee Nelson, J
N1 - © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: In a preliminary case-control study, women with scleroderma more frequently reported having had hypertensive complications during pregnancy compared with healthy women.MATERIAL AND METHODS: To prospectively investigate this possible association, we conducted a nation-wide cohort analysis of a major hypertensive complication during pregnancy, namely preeclampsia, and later scleroderma. Analyses were based on Danish register-based birth and hospital contact data on preeclampsia and scleroderma. We followed 778,758 women from time of giving birth between 1978 and 2010 to end of follow-up, emigration, death, or scleroderma diagnosis, whichever occurred first. The association was evaluated by incidence rate ratios, obtained in Poisson regression models.RESULTS: We report that preeclampsia is associated with a 69% significantly increased risk of later developing scleroderma.CONCLUSIONS: Though these findings do not impact clinical care directly, the association of preeclampsia with scleroderma underscores the significant relation of preeclampsia and other adverse pregnancy outcomes with later disease in women and should be included in patient counseling and education.
AB - INTRODUCTION: In a preliminary case-control study, women with scleroderma more frequently reported having had hypertensive complications during pregnancy compared with healthy women.MATERIAL AND METHODS: To prospectively investigate this possible association, we conducted a nation-wide cohort analysis of a major hypertensive complication during pregnancy, namely preeclampsia, and later scleroderma. Analyses were based on Danish register-based birth and hospital contact data on preeclampsia and scleroderma. We followed 778,758 women from time of giving birth between 1978 and 2010 to end of follow-up, emigration, death, or scleroderma diagnosis, whichever occurred first. The association was evaluated by incidence rate ratios, obtained in Poisson regression models.RESULTS: We report that preeclampsia is associated with a 69% significantly increased risk of later developing scleroderma.CONCLUSIONS: Though these findings do not impact clinical care directly, the association of preeclampsia with scleroderma underscores the significant relation of preeclampsia and other adverse pregnancy outcomes with later disease in women and should be included in patient counseling and education.
U2 - 10.1111/aogs.13296
DO - 10.1111/aogs.13296
M3 - Journal article
C2 - 29344946
VL - 97
SP - 587
EP - 590
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 5
ER -
ID: 198661890