Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice

Research output: Contribution to journalJournal articlepeer-review

Standard

Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice. / Hemmingsen, Jette Gjerke; Hougaard, Karin Sørig; Talsness, Chris; Wellejus, Anja; Loft, Steffen; Wallin, Håkan; Møller, Peter.

In: Toxicology, Vol. 264, No. 1-2, 2009, p. 61-8.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hemmingsen, JG, Hougaard, KS, Talsness, C, Wellejus, A, Loft, S, Wallin, H & Møller, P 2009, 'Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice', Toxicology, vol. 264, no. 1-2, pp. 61-8. https://doi.org/10.1016/j.tox.2009.07.012

APA

Hemmingsen, J. G., Hougaard, K. S., Talsness, C., Wellejus, A., Loft, S., Wallin, H., & Møller, P. (2009). Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice. Toxicology, 264(1-2), 61-8. https://doi.org/10.1016/j.tox.2009.07.012

Vancouver

Hemmingsen JG, Hougaard KS, Talsness C, Wellejus A, Loft S, Wallin H et al. Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice. Toxicology. 2009;264(1-2):61-8. https://doi.org/10.1016/j.tox.2009.07.012

Author

Hemmingsen, Jette Gjerke ; Hougaard, Karin Sørig ; Talsness, Chris ; Wellejus, Anja ; Loft, Steffen ; Wallin, Håkan ; Møller, Peter. / Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice. In: Toxicology. 2009 ; Vol. 264, No. 1-2. pp. 61-8.

Bibtex

@article{23a97080a10c11debc73000ea68e967b,
title = "Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice",
abstract = "In utero exposure to diesel exhaust particles may reduce sperm production in adulthood. We investigated the effect of prenatal exposure to diesel exhaust particles on the male reproductive system and assessed endocrine disruption and regulation of aquaporin expression as possible mechanisms of action. Dams inhaled 20 mg/m(3) of diesel exhaust particle standard reference material 2975 (SRM2975) or clean air for 1h/day on day 7-19 during pregnancy. Male offspring were killed on day 170 after birth. The dams that had inhaled SRM2975 delivered offspring, which in adulthood had reduced daily sperm production (P=0.046, Mann-Whitney U-test), whereas there were no differences in the body weight, testis weight and anogenital distance. There was no difference in plasma testosterone and estradiol concentrations, although some samples were not analyzed precisely because of technical problems. The gene regulation of the androgen receptor, anti-M{\"u}llerian hormone, estrogen receptor-alpha, estrogen receptor-beta, follicle-stimulating hormone receptor, insulin-like growth factor 3, luteinising hormone receptor, and aromatase in testes, were not significantly altered in the group exposed in utero to SRM2975 compared to controls. These data indicate that prenatal exposure to SRM2975 was not associated with endocrine disruptor activity in adulthood. There was no significant change in expression levels of aquaporins 7, 8 and 9 in testes tissue, measured as mRNA expression and protein levels by immunohistochemistry. In conclusion, prenatal exposure to SRM2975 was associated with reduced daily sperm production in adulthood, which was not possible to clearly associate with altered endocrine function or expression of aquaporins in the testes.",
author = "Hemmingsen, {Jette Gjerke} and Hougaard, {Karin S{\o}rig} and Chris Talsness and Anja Wellejus and Steffen Loft and H{\aa}kan Wallin and Peter M{\o}ller",
note = "2009 Elsevier Ireland Ltd.",
year = "2009",
doi = "10.1016/j.tox.2009.07.012",
language = "English",
volume = "264",
pages = "61--8",
journal = "Toxicology",
issn = "0300-483X",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice

AU - Hemmingsen, Jette Gjerke

AU - Hougaard, Karin Sørig

AU - Talsness, Chris

AU - Wellejus, Anja

AU - Loft, Steffen

AU - Wallin, Håkan

AU - Møller, Peter

N1 - 2009 Elsevier Ireland Ltd.

PY - 2009

Y1 - 2009

N2 - In utero exposure to diesel exhaust particles may reduce sperm production in adulthood. We investigated the effect of prenatal exposure to diesel exhaust particles on the male reproductive system and assessed endocrine disruption and regulation of aquaporin expression as possible mechanisms of action. Dams inhaled 20 mg/m(3) of diesel exhaust particle standard reference material 2975 (SRM2975) or clean air for 1h/day on day 7-19 during pregnancy. Male offspring were killed on day 170 after birth. The dams that had inhaled SRM2975 delivered offspring, which in adulthood had reduced daily sperm production (P=0.046, Mann-Whitney U-test), whereas there were no differences in the body weight, testis weight and anogenital distance. There was no difference in plasma testosterone and estradiol concentrations, although some samples were not analyzed precisely because of technical problems. The gene regulation of the androgen receptor, anti-Müllerian hormone, estrogen receptor-alpha, estrogen receptor-beta, follicle-stimulating hormone receptor, insulin-like growth factor 3, luteinising hormone receptor, and aromatase in testes, were not significantly altered in the group exposed in utero to SRM2975 compared to controls. These data indicate that prenatal exposure to SRM2975 was not associated with endocrine disruptor activity in adulthood. There was no significant change in expression levels of aquaporins 7, 8 and 9 in testes tissue, measured as mRNA expression and protein levels by immunohistochemistry. In conclusion, prenatal exposure to SRM2975 was associated with reduced daily sperm production in adulthood, which was not possible to clearly associate with altered endocrine function or expression of aquaporins in the testes.

AB - In utero exposure to diesel exhaust particles may reduce sperm production in adulthood. We investigated the effect of prenatal exposure to diesel exhaust particles on the male reproductive system and assessed endocrine disruption and regulation of aquaporin expression as possible mechanisms of action. Dams inhaled 20 mg/m(3) of diesel exhaust particle standard reference material 2975 (SRM2975) or clean air for 1h/day on day 7-19 during pregnancy. Male offspring were killed on day 170 after birth. The dams that had inhaled SRM2975 delivered offspring, which in adulthood had reduced daily sperm production (P=0.046, Mann-Whitney U-test), whereas there were no differences in the body weight, testis weight and anogenital distance. There was no difference in plasma testosterone and estradiol concentrations, although some samples were not analyzed precisely because of technical problems. The gene regulation of the androgen receptor, anti-Müllerian hormone, estrogen receptor-alpha, estrogen receptor-beta, follicle-stimulating hormone receptor, insulin-like growth factor 3, luteinising hormone receptor, and aromatase in testes, were not significantly altered in the group exposed in utero to SRM2975 compared to controls. These data indicate that prenatal exposure to SRM2975 was not associated with endocrine disruptor activity in adulthood. There was no significant change in expression levels of aquaporins 7, 8 and 9 in testes tissue, measured as mRNA expression and protein levels by immunohistochemistry. In conclusion, prenatal exposure to SRM2975 was associated with reduced daily sperm production in adulthood, which was not possible to clearly associate with altered endocrine function or expression of aquaporins in the testes.

U2 - 10.1016/j.tox.2009.07.012

DO - 10.1016/j.tox.2009.07.012

M3 - Journal article

C2 - 19632294

VL - 264

SP - 61

EP - 68

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 1-2

ER -

ID: 14411541