Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children
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Preterm birth, infant weight gain, and childhood asthma risk : a meta-analysis of 147,000 European children. / Sonnenschein-van der Voort, Agnes M M; Arends, Lidia R; de Jongste, Johan C; Annesi-Maesano, Isabella; Arshad, S Hasan; Barros, Henrique; Basterrechea, Mikel; Bisgaard, Hans; Chatzi, Leda; Corpeleijn, Eva; Correia, Sofia; Craig, Leone C; Devereux, Graham; Dogaru, Cristian; Dostal, Miroslav; Duchen, Karel; Eggesbø, Merete; van der Ent, C Kors; Fantini, Maria P; Forastiere, Francesco; Frey, Urs; Gehring, Ulrike; Gori, Davide; van der Gugten, Anne C; Hanke, Wojciech; Henderson, A John; Heude, Barbara; Iñiguez, Carmen; Inskip, Hazel M; Keil, Thomas; Kelleher, Cecily C; Kogevinas, Manolis; Kreiner-Møller, Eskil; Kuehni, Claudia E; Küpers, Leanne K; Lancz, Kinga; Larsen, Pernille S; Lau, Susanne; Ludvigsson, Johnny; Mommers, Monique; Andersen, Anne-Marie Nybo; Palkovicova, Lubica; Pike, Katharine C; Pizzi, Costanza; Polanska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Roberts, Graham; Schmidt, Anne; Sram, Radim J; Sunyer, Jordi; Thijs, Carel; Torrent, Maties; Viljoen, Karien; Wijga, Alet H; Vrijheid, Martine; Jaddoe, Vincent W V; Duijts, Liesbeth.
In: The Journal of allergy and clinical immunology, Vol. 133, No. 5, 05.2014, p. 1317-29.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Preterm birth, infant weight gain, and childhood asthma risk
T2 - a meta-analysis of 147,000 European children
AU - Sonnenschein-van der Voort, Agnes M M
AU - Arends, Lidia R
AU - de Jongste, Johan C
AU - Annesi-Maesano, Isabella
AU - Arshad, S Hasan
AU - Barros, Henrique
AU - Basterrechea, Mikel
AU - Bisgaard, Hans
AU - Chatzi, Leda
AU - Corpeleijn, Eva
AU - Correia, Sofia
AU - Craig, Leone C
AU - Devereux, Graham
AU - Dogaru, Cristian
AU - Dostal, Miroslav
AU - Duchen, Karel
AU - Eggesbø, Merete
AU - van der Ent, C Kors
AU - Fantini, Maria P
AU - Forastiere, Francesco
AU - Frey, Urs
AU - Gehring, Ulrike
AU - Gori, Davide
AU - van der Gugten, Anne C
AU - Hanke, Wojciech
AU - Henderson, A John
AU - Heude, Barbara
AU - Iñiguez, Carmen
AU - Inskip, Hazel M
AU - Keil, Thomas
AU - Kelleher, Cecily C
AU - Kogevinas, Manolis
AU - Kreiner-Møller, Eskil
AU - Kuehni, Claudia E
AU - Küpers, Leanne K
AU - Lancz, Kinga
AU - Larsen, Pernille S
AU - Lau, Susanne
AU - Ludvigsson, Johnny
AU - Mommers, Monique
AU - Andersen, Anne-Marie Nybo
AU - Palkovicova, Lubica
AU - Pike, Katharine C
AU - Pizzi, Costanza
AU - Polanska, Kinga
AU - Porta, Daniela
AU - Richiardi, Lorenzo
AU - Roberts, Graham
AU - Schmidt, Anne
AU - Sram, Radim J
AU - Sunyer, Jordi
AU - Thijs, Carel
AU - Torrent, Maties
AU - Viljoen, Karien
AU - Wijga, Alet H
AU - Vrijheid, Martine
AU - Jaddoe, Vincent W V
AU - Duijts, Liesbeth
N1 - Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
PY - 2014/5
Y1 - 2014/5
N2 - BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.
AB - BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.
U2 - 10.1016/j.jaci.2013.12.1082
DO - 10.1016/j.jaci.2013.12.1082
M3 - Journal article
C2 - 24529685
VL - 133
SP - 1317
EP - 1329
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 5
ER -
ID: 120538151