Prevalence of epilepsy in China between 1990 and 2015: A systematic review and meta-analysis

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Prevalence of epilepsy in China between 1990 and 2015 : A systematic review and meta-analysis. / Song, Peige; Liu, Yezhou; Yu, Xinwei; Wu, Jingjing; Poon, Adrienne N.; Demaio, Alessandro; Wang, Wei; Rudan, Igor; Chan, Kit Yee.

In: Global Journal of Health Science, Vol. 7, No. 2, 020706, 12.2017, p. 1-11.

Research output: Contribution to journalReviewpeer-review

Harvard

Song, P, Liu, Y, Yu, X, Wu, J, Poon, AN, Demaio, A, Wang, W, Rudan, I & Chan, KY 2017, 'Prevalence of epilepsy in China between 1990 and 2015: A systematic review and meta-analysis', Global Journal of Health Science, vol. 7, no. 2, 020706, pp. 1-11. https://doi.org/10.7189/jogh.07.020706

APA

Song, P., Liu, Y., Yu, X., Wu, J., Poon, A. N., Demaio, A., Wang, W., Rudan, I., & Chan, K. Y. (2017). Prevalence of epilepsy in China between 1990 and 2015: A systematic review and meta-analysis. Global Journal of Health Science, 7(2), 1-11. [020706]. https://doi.org/10.7189/jogh.07.020706

Vancouver

Song P, Liu Y, Yu X, Wu J, Poon AN, Demaio A et al. Prevalence of epilepsy in China between 1990 and 2015: A systematic review and meta-analysis. Global Journal of Health Science. 2017 Dec;7(2):1-11. 020706. https://doi.org/10.7189/jogh.07.020706

Author

Song, Peige ; Liu, Yezhou ; Yu, Xinwei ; Wu, Jingjing ; Poon, Adrienne N. ; Demaio, Alessandro ; Wang, Wei ; Rudan, Igor ; Chan, Kit Yee. / Prevalence of epilepsy in China between 1990 and 2015 : A systematic review and meta-analysis. In: Global Journal of Health Science. 2017 ; Vol. 7, No. 2. pp. 1-11.

Bibtex

@article{81273407f28143a0afe3264b61f406e1,
title = "Prevalence of epilepsy in China between 1990 and 2015: A systematic review and meta-analysis",
abstract = "Background: Epilepsy is a major neurological disorder that affects approximately 65 million people worldwide. Globally, the burden of epilepsy is not evenly distributed, with more than 80% of sufferers residing in low– and middle–income countries. This study estimates the burden of epilepsy in mainland China from 1990 to 2015and explores the variations of burden by age and gender.Methods: We conducted a systematic review of the peer–reviewed literature from 1990 to 2015 using Chinese and English academic databases (CNKI, WanFang, VIP and PubMed) to identify population–based prospective studies on the prevalence of epilepsy in mainland Chinese. Multilevel mixed–effects logistic regression was used to estimate the prevalence of lifetime epilepsy (LTE), and restricted cubic regression splines were applied to model the functional forms of the non–linear effects of age and LTE prevalence. Random–effects meta–analysis was used to obtain the pooled prevalence of 1–year active epilepsy (AE), 2–year AE and 5–year AE separately. To estimate the number of people with LTE and AE in the years 1990, 2000, and 2015, LTE and AE prevalence were multiplied by the total population of mainland China of the corresponding year. Findings: Analyses were conducted using 39 prevalence studies that met the inclusion criteria and comprised 77 separate data points (37on LTE, 16 on 1–year AE, 12 on 2–year AE and 12 on 5–year AE). In 1990, the prevalence of LTE ranged from 1.31‰ (95% CI = 0.85–2.00) in the 0–4 age group to 2.42‰ (95% confidence interval CI = 1.60–3.65) in the 30–34 age group. By 2015, the LTE prevalence had increased to 4.57‰ (95% CI = 2.52–8.27) in the 0–4 group and 8.43‰ (95% CI = 4.71–15.04) in the 30–34 group. Over the 25–year period, the overall prevalence of LTE had steadily increased by 259%, from 1.99‰ (95% CI = 1.31–3.02) in 1990 to7.15‰ (95% CI = 3.98–12.82) in 2015. The rates of increase were similar across the whole age spectrum, fluctuating around 250%. Between 1990 and 2015, the total number of people with LTE inmainland China increased by 328%, from 2.30 million (95%CI = 1.51–3.49) in 1990 to 9.84 million (95% CI = 5.48–17.64) in 2015. The pooled 1–year, 2–year, and 5–year AE prevalence were3.79‰ (95% CI = 3.31–4.34), 4.08‰ (95% CI = 3.41–4.89) and4.19‰ (95% CI = 3.42–5.15). Conclusions: The burden of LTE in China has increased substantially between 1990 and 2015, with the prevalence of LTE having more than doubled and the number of people with LTE more than tripled. The large amount of AE cases in China calls for optimal management and treatment. More high–quality epidemiological studies on LTE and AE prevalence are still needed. ",
author = "Peige Song and Yezhou Liu and Xinwei Yu and Jingjing Wu and Poon, {Adrienne N.} and Alessandro Demaio and Wei Wang and Igor Rudan and Chan, {Kit Yee}",
year = "2017",
month = dec,
doi = "10.7189/jogh.07.020706",
language = "English",
volume = "7",
pages = "1--11",
journal = "Global journal of health science",
issn = "1916-9736",
publisher = "Canadian Center of Science and Education",
number = "2",

}

RIS

TY - JOUR

T1 - Prevalence of epilepsy in China between 1990 and 2015

T2 - A systematic review and meta-analysis

AU - Song, Peige

AU - Liu, Yezhou

AU - Yu, Xinwei

AU - Wu, Jingjing

AU - Poon, Adrienne N.

AU - Demaio, Alessandro

AU - Wang, Wei

AU - Rudan, Igor

AU - Chan, Kit Yee

PY - 2017/12

Y1 - 2017/12

N2 - Background: Epilepsy is a major neurological disorder that affects approximately 65 million people worldwide. Globally, the burden of epilepsy is not evenly distributed, with more than 80% of sufferers residing in low– and middle–income countries. This study estimates the burden of epilepsy in mainland China from 1990 to 2015and explores the variations of burden by age and gender.Methods: We conducted a systematic review of the peer–reviewed literature from 1990 to 2015 using Chinese and English academic databases (CNKI, WanFang, VIP and PubMed) to identify population–based prospective studies on the prevalence of epilepsy in mainland Chinese. Multilevel mixed–effects logistic regression was used to estimate the prevalence of lifetime epilepsy (LTE), and restricted cubic regression splines were applied to model the functional forms of the non–linear effects of age and LTE prevalence. Random–effects meta–analysis was used to obtain the pooled prevalence of 1–year active epilepsy (AE), 2–year AE and 5–year AE separately. To estimate the number of people with LTE and AE in the years 1990, 2000, and 2015, LTE and AE prevalence were multiplied by the total population of mainland China of the corresponding year. Findings: Analyses were conducted using 39 prevalence studies that met the inclusion criteria and comprised 77 separate data points (37on LTE, 16 on 1–year AE, 12 on 2–year AE and 12 on 5–year AE). In 1990, the prevalence of LTE ranged from 1.31‰ (95% CI = 0.85–2.00) in the 0–4 age group to 2.42‰ (95% confidence interval CI = 1.60–3.65) in the 30–34 age group. By 2015, the LTE prevalence had increased to 4.57‰ (95% CI = 2.52–8.27) in the 0–4 group and 8.43‰ (95% CI = 4.71–15.04) in the 30–34 group. Over the 25–year period, the overall prevalence of LTE had steadily increased by 259%, from 1.99‰ (95% CI = 1.31–3.02) in 1990 to7.15‰ (95% CI = 3.98–12.82) in 2015. The rates of increase were similar across the whole age spectrum, fluctuating around 250%. Between 1990 and 2015, the total number of people with LTE inmainland China increased by 328%, from 2.30 million (95%CI = 1.51–3.49) in 1990 to 9.84 million (95% CI = 5.48–17.64) in 2015. The pooled 1–year, 2–year, and 5–year AE prevalence were3.79‰ (95% CI = 3.31–4.34), 4.08‰ (95% CI = 3.41–4.89) and4.19‰ (95% CI = 3.42–5.15). Conclusions: The burden of LTE in China has increased substantially between 1990 and 2015, with the prevalence of LTE having more than doubled and the number of people with LTE more than tripled. The large amount of AE cases in China calls for optimal management and treatment. More high–quality epidemiological studies on LTE and AE prevalence are still needed.

AB - Background: Epilepsy is a major neurological disorder that affects approximately 65 million people worldwide. Globally, the burden of epilepsy is not evenly distributed, with more than 80% of sufferers residing in low– and middle–income countries. This study estimates the burden of epilepsy in mainland China from 1990 to 2015and explores the variations of burden by age and gender.Methods: We conducted a systematic review of the peer–reviewed literature from 1990 to 2015 using Chinese and English academic databases (CNKI, WanFang, VIP and PubMed) to identify population–based prospective studies on the prevalence of epilepsy in mainland Chinese. Multilevel mixed–effects logistic regression was used to estimate the prevalence of lifetime epilepsy (LTE), and restricted cubic regression splines were applied to model the functional forms of the non–linear effects of age and LTE prevalence. Random–effects meta–analysis was used to obtain the pooled prevalence of 1–year active epilepsy (AE), 2–year AE and 5–year AE separately. To estimate the number of people with LTE and AE in the years 1990, 2000, and 2015, LTE and AE prevalence were multiplied by the total population of mainland China of the corresponding year. Findings: Analyses were conducted using 39 prevalence studies that met the inclusion criteria and comprised 77 separate data points (37on LTE, 16 on 1–year AE, 12 on 2–year AE and 12 on 5–year AE). In 1990, the prevalence of LTE ranged from 1.31‰ (95% CI = 0.85–2.00) in the 0–4 age group to 2.42‰ (95% confidence interval CI = 1.60–3.65) in the 30–34 age group. By 2015, the LTE prevalence had increased to 4.57‰ (95% CI = 2.52–8.27) in the 0–4 group and 8.43‰ (95% CI = 4.71–15.04) in the 30–34 group. Over the 25–year period, the overall prevalence of LTE had steadily increased by 259%, from 1.99‰ (95% CI = 1.31–3.02) in 1990 to7.15‰ (95% CI = 3.98–12.82) in 2015. The rates of increase were similar across the whole age spectrum, fluctuating around 250%. Between 1990 and 2015, the total number of people with LTE inmainland China increased by 328%, from 2.30 million (95%CI = 1.51–3.49) in 1990 to 9.84 million (95% CI = 5.48–17.64) in 2015. The pooled 1–year, 2–year, and 5–year AE prevalence were3.79‰ (95% CI = 3.31–4.34), 4.08‰ (95% CI = 3.41–4.89) and4.19‰ (95% CI = 3.42–5.15). Conclusions: The burden of LTE in China has increased substantially between 1990 and 2015, with the prevalence of LTE having more than doubled and the number of people with LTE more than tripled. The large amount of AE cases in China calls for optimal management and treatment. More high–quality epidemiological studies on LTE and AE prevalence are still needed.

U2 - 10.7189/jogh.07.020706

DO - 10.7189/jogh.07.020706

M3 - Review

VL - 7

SP - 1

EP - 11

JO - Global journal of health science

JF - Global journal of health science

SN - 1916-9736

IS - 2

M1 - 020706

ER -

ID: 188451504