Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET

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Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. / Ettrup, Anders; Palner, Mikael; Gillings, Nic; Santini, Martin A; Hansen, Martin; Kornum, Birgitte Rahbek; Rasmussen, Lars Kyhn; Någren, Kjell ; Madsen, Jacob; Begtrup, Mikael; Knudsen, Gitte Moos.

In: Journal of Nuclear Medicine, Vol. 51, No. 11, 01.11.2010, p. 1763-1770.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ettrup, A, Palner, M, Gillings, N, Santini, MA, Hansen, M, Kornum, BR, Rasmussen, LK, Någren, K, Madsen, J, Begtrup, M & Knudsen, GM 2010, 'Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET', Journal of Nuclear Medicine, vol. 51, no. 11, pp. 1763-1770. https://doi.org/10.2967/jnumed.109.074021

APA

Ettrup, A., Palner, M., Gillings, N., Santini, M. A., Hansen, M., Kornum, B. R., ... Knudsen, G. M. (2010). Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. Journal of Nuclear Medicine, 51(11), 1763-1770. https://doi.org/10.2967/jnumed.109.074021

Vancouver

Ettrup A, Palner M, Gillings N, Santini MA, Hansen M, Kornum BR et al. Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. Journal of Nuclear Medicine. 2010 Nov 1;51(11):1763-1770. https://doi.org/10.2967/jnumed.109.074021

Author

Ettrup, Anders ; Palner, Mikael ; Gillings, Nic ; Santini, Martin A ; Hansen, Martin ; Kornum, Birgitte Rahbek ; Rasmussen, Lars Kyhn ; Någren, Kjell ; Madsen, Jacob ; Begtrup, Mikael ; Knudsen, Gitte Moos. / Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET. In: Journal of Nuclear Medicine. 2010 ; Vol. 51, No. 11. pp. 1763-1770.

Bibtex

@article{6aa85cb785084eb4a30a0168b365501d,
title = "Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET",
abstract = "PET brain imaging of the serotonin 2A (5-hydroxytryptamine 2A, or 5-HT(2A)) receptor has been widely used in clinical studies, and currently, several well-validated radiolabeled antagonist tracers are used for in vivo imaging of the cerebral 5-HT(2A) receptor. Access to 5-HT(2A) receptor agonist PET tracers would, however, enable imaging of the active, high-affinity state of receptors, which may provide a more meaningful assessment of membrane-bound receptors. In this study, we radiolabel the high-affinity 5-HT(2A) receptor agonist 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-[(11)C-OCH(3)]methoxybenzyl)ethanamine ((11)C-CIMBI-5) and investigate its potential as a PET tracer.",
keywords = "Faculty of Health and Medical Sciences",
author = "Anders Ettrup and Mikael Palner and Nic Gillings and Santini, {Martin A} and Martin Hansen and Kornum, {Birgitte Rahbek} and Rasmussen, {Lars Kyhn} and Kjell N{\aa}gren and Jacob Madsen and Mikael Begtrup and Knudsen, {Gitte Moos}",
note = "Keywords: PET tracer development, agonist, porcine, serotonin receptors",
year = "2010",
month = "11",
day = "1",
doi = "10.2967/jnumed.109.074021",
language = "English",
volume = "51",
pages = "1763--1770",
journal = "The Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine",
number = "11",

}

RIS

TY - JOUR

T1 - Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET

AU - Ettrup, Anders

AU - Palner, Mikael

AU - Gillings, Nic

AU - Santini, Martin A

AU - Hansen, Martin

AU - Kornum, Birgitte Rahbek

AU - Rasmussen, Lars Kyhn

AU - Någren, Kjell

AU - Madsen, Jacob

AU - Begtrup, Mikael

AU - Knudsen, Gitte Moos

N1 - Keywords: PET tracer development, agonist, porcine, serotonin receptors

PY - 2010/11/1

Y1 - 2010/11/1

N2 - PET brain imaging of the serotonin 2A (5-hydroxytryptamine 2A, or 5-HT(2A)) receptor has been widely used in clinical studies, and currently, several well-validated radiolabeled antagonist tracers are used for in vivo imaging of the cerebral 5-HT(2A) receptor. Access to 5-HT(2A) receptor agonist PET tracers would, however, enable imaging of the active, high-affinity state of receptors, which may provide a more meaningful assessment of membrane-bound receptors. In this study, we radiolabel the high-affinity 5-HT(2A) receptor agonist 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-[(11)C-OCH(3)]methoxybenzyl)ethanamine ((11)C-CIMBI-5) and investigate its potential as a PET tracer.

AB - PET brain imaging of the serotonin 2A (5-hydroxytryptamine 2A, or 5-HT(2A)) receptor has been widely used in clinical studies, and currently, several well-validated radiolabeled antagonist tracers are used for in vivo imaging of the cerebral 5-HT(2A) receptor. Access to 5-HT(2A) receptor agonist PET tracers would, however, enable imaging of the active, high-affinity state of receptors, which may provide a more meaningful assessment of membrane-bound receptors. In this study, we radiolabel the high-affinity 5-HT(2A) receptor agonist 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-[(11)C-OCH(3)]methoxybenzyl)ethanamine ((11)C-CIMBI-5) and investigate its potential as a PET tracer.

KW - Faculty of Health and Medical Sciences

U2 - 10.2967/jnumed.109.074021

DO - 10.2967/jnumed.109.074021

M3 - Journal article

C2 - 20956470

VL - 51

SP - 1763

EP - 1770

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

SN - 0161-5505

IS - 11

ER -

ID: 33532568